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ACUTE EFFECTS OF INSULIN DEFICIENCY IN DIABETES MELLITUS

ACUTE EFFECTS OF INSULIN DEFICIENCY IN DIABETES MELLITUS. D. C. MIKULECKY Dept. Physiology. EFFECTS OF INSULIN DEFICIENCY. INCREASED HEPATIC GLUCOSE OUTPUT FROM GLYCOGEN STORES FAT AND MUSCLE CELLS UNABLE TO TAKE UP GLUCOSE FALL IN TRIGLYCERIDE SYNTHESIS IN ADIPOCYTES INCREASED LYPOLYSIS

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ACUTE EFFECTS OF INSULIN DEFICIENCY IN DIABETES MELLITUS

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  1. ACUTE EFFECTS OF INSULIN DEFICIENCY IN DIABETES MELLITUS D. C. MIKULECKY Dept. Physiology

  2. EFFECTS OF INSULIN DEFICIENCY • INCREASED HEPATIC GLUCOSE OUTPUT FROM GLYCOGEN STORES • FAT AND MUSCLE CELLS UNABLE TO TAKE UP GLUCOSE • FALL IN TRIGLYCERIDE SYNTHESIS IN ADIPOCYTES • INCREASED LYPOLYSIS • FALL IN AMINO ACID UPTAKE BY CELLS • INCREASED PROTEIN DEGRADATION

  3. EFFECTS OF INSULIN DEFICIENCY: HYPERGLYCEMIA • INCREASED HEPATIC GLUCOSE OUTPUT FROM GLYCOGEN STORES • FAT AND MUSCLE CELLS UNABLE TO TAKE UP GLUCOSE

  4. EFFECT OF HYPERGLYCEMIA • GLUCOSURIA • OSMOTIC DIURESIS • POLYURIA • DEHYDRATION

  5. POLYDIPSIA CELLULAR SHRINKING BRAIN CELLS ARE DYSFUNCTIONAL AS A RESULT NERVOUS SYSTEM MALFUNCTION DEATH FALL IN BLOOD VOLUME PERIPHERAL CIRULATORY FAILURE RENAL FAILURE DEATH EFFECTS OF DEHYDRATION

  6. EFFECTS OF INSULIN DEFICIENCY: INCREASED BLOOD FATTY ACIDS • FALL IN TRIGLYCERIDE SYNTHESIS IN ADIPOCYTES • INCREASED LYPOLYSIS

  7. EFFECT OF INCREASED BLOOD FATTY ACIDS AND FAILURE OF GLUCOSE TO ENTER CELLS • UTILIZATION OF FAT AS PRIMARY ENERGY SOURCE • KETOSIS • METABOLIC ACIDOSIS AND INCREASED VENTILATION AS A RESULT • DEPRESSIVE EFFECT ON BRAIN FROM ACIDOSIS • DIABETIC COMA • DEATH

  8. EFFECTS OF INSULIN DEFICIENCY: PROTEIN • FALL IN AMINO ACID UPTAKE BY CELLS • INCREASED PROTEIN DEGRADATION • LOSS OF MUSCLE MASS • WEIGHT LOSS • AGGRIVATION OF HYPERGLYCEMIA DUE TO GLUCONEOGENESIS

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