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Gene Ontology Project geneontology/

The Gene Ontology (GO) project is a powerful tool for unifying and categorizing biological information, making it easier for researchers to analyze and interpret data. This article explores the wide range of organizations and publications that use GO, as well as the various products and services that incorporate GO. It also highlights the specific case of Mitochondrial P450 and its related functions and gene products. Furthermore, it discusses the application of GO in whole genome analysis and high-throughput data analysis, providing insights into defense response, immune response, and various regulated genes.

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Gene Ontology Project geneontology/

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  1. Gene Ontology Project http://www.geneontology.org/

  2. Clark et al., 2005 is_a part_of

  3. Clark et al., 2005

  4. Who uses GO?

  5. National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institute on Aging (NIA) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Center for Complementary and Alternative Medicine (NCCAM) National Cancer Institute (NCI) National Institute on Drug Abuse (NIDA) National Institute on Deafness and Other Communication Disorders (NIDCD) National Institute of Dental & Craniofacial Research (NIDCR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Environmental Health Sciences (NIEHS) 13. National Eye Institute (NEI) 14. National Institute of General Medical Sciences (NIGMS) 15. National Institute of Child Health and Human Development (NICHD) 16. National Human Genome Research Institute (NHGRI) 17. National Heart, Lung and Blood Institute (NHLBI) 18. National Library of Medicine (NLM) 19. National Center on Minority Health and Health Disparities (NCMHD) 20. National Institute of Mental Health (NIMH) 21. National Institute of Nursing Research (NINR) 22. National Institute of Neurological Disorders and Stroke (NINDS) 23. National Center for Research Resources (NCRR) 24. Fogarty International Center (FIC) NIH funded experimental research that uses the GO Sample of 77 research papers, both intra-mural & extra-mural research.

  6. Companies • NLP & Ontology ProductsBioWisdom, IBM • Array Products and data analysis Affymetrix, Spotfire • Products that use GO Clontech, Inpharmatica • Reagents & services Sigma, Abnova • Big Pharmas AstraZeneca

  7. Publications • Published articles mentioning GO = 1063, in 284 journals • Google Scholar • ‘gene ontology, tool for unification of biology’ 1291 citations 25th September 2006

  8. Who is citing GO? 450 1063 publications over 284 Journals http://www.geneontology.org/cgi-bin/biblio.cgi

  9. Annotation Mitochondrial P450 (CC24 PR01238; MITP450CC24)

  10. Where is it? Mitochondrial p450 GO cellular component term: mitochondrial inner membrane ; GO:0005743

  11. What does it do? substrate + O2 = CO2 +H20 product GO molecular function term: monooxygenase activity ; GO:0004497

  12. Which process is this? GO biological process term: electron transport ; GO:0006118 http://ntri.tamuk.edu/cell/mitochondrion/krebpic.html

  13. monooxygenase activity ; GO:0004497 Other gene products: MGI monooxygenase, DBH-like 1 MGI prostaglandin I2 (prostacyclin) synthase MGI splicing factor 3b, subunit 2 SGD    flavin-containing monooxygenase TAIR   FERULATE-5-HYDROXYLASE 1

  14. Cell type ontology

  15. Whole genome analysis (J. D. Munkvold et al., 2004)

  16. …analysis of high-throughput data according to GO time Defense response Immune response Response to stimulus Toll regulated genes JAK-STAT regulated genes Puparial adhesion Molting cycle hemocyanin Amino acid catabolism Lipid metobolism Peptidase activity Protein catabloism Immune response Immune response Toll regulated genes control attacked MicroArray data analysis Bregje Wertheim at the Centre for Evolutionary Genomics, Department of Biology, UCL and Eugene Schuster Group, EBI.

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