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Chances & Challenges of Bioinformatics in TCM

Chances & Challenges of Bioinformatics in TCM. Prof. Qiao Yanjiang Zhang Yanling collean_zhang@163.com Beijing University of Chinese Medicine. Outline. Background Chances and Challenges Brief Idea of Our Work A Simple Example. Puzzles in TCM. Bioinformatics can do in TCM.

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Chances & Challenges of Bioinformatics in TCM

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  1. Chances & Challenges of Bioinformatics in TCM Prof. Qiao Yanjiang Zhang Yanling collean_zhang@163.com Beijing University of Chinese Medicine

  2. Outline • Background • Chances and Challenges • Brief Idea of Our Work • A Simple Example

  3. Puzzles in TCM

  4. Bioinformatics can do in TCM 1R4L  from PDB Pathway form KEGG

  5. Chances How to communicate with modern science? How to make a further progress? Integral and traditional Theory Thousands of years of clinical experience More than nine thousand material medica

  6. Challenges Harmony & Wholism Syndrome Differentiation

  7. Brief Idea of Our Work

  8. Virtual Screening D：number of molecules in database A：number of active molecules in database H：number of hit molecules AH：number of active molecules in hitlist

  9. Blue = medicine 1 Yellow = medicine 2 Green = medicine 3 Black= superposition of two webs Red= superposition of three webs Model of Cancer

  10. Formulas Herbs Compounds ? Formula= Herb1+Herb2+……+Herbn Herb= Compound1+Compound2+……+Compoundj Formula = Compound1+Compound2+……+Compoundm f ( ) ? f ( ) ? f ( )

  11. Compounds Database of Fufang Danshen Tablets

  12. HMG -CoA T-cell TNFɑ COX2 PDE AngII

  13. Thanks for Your Attention! We’re Waiting forYOU!

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