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sporadic forms of AD

sporadic forms of AD. 25%. 50%. 100% (presence of NFT). Transentorhinal cortex. Entorhinal cortex. Hippocampus. Temporal pole. Inf temporal cortex. Mid temporal cortex. Threshold for dementia. APP*. APP*. APP*. Polymodal association ctx. Unimodal areas.

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sporadic forms of AD

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  1. sporadic forms of AD 25% 50% 100% (presence of NFT) Transentorhinal cortex Entorhinal cortex Hippocampus Temporal pole Inf temporal cortex Mid temporal cortex Threshold for dementia APP* APP* APP* Polymodal association ctx Unimodal areas Primary cortex APP* Aging and Alzheimer's disease S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 S10 Pathway of tau pathology Stages of tau pathology 45 55 65 75 85 years

  2. Transentorhinal Temporal pole Association ctx APP* APP* APP* Primary ctx Entorhinal Hippocampus Temporal inf Temporal mid Unimodal ctx Alzheimer's disease Familial Autosomic Dominant AD Pathway of tau pathology S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 S10 40 25 50 Stages of tau pathology Years

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