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Applications of alginates are based on 3 properties: Increase viscosity of aqueous solutions Ability to form gel Ability to form films of and fibers. Textile Industry Thickeners for paste containing dyes Do not react with reactive dyes and easily wash out of finished textile
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Applications of alginates are based on 3 properties: • Increase viscosity of aqueous solutions • Ability to form gel • Ability to form films of and fibers • Textile Industry • Thickeners for paste containing dyes • Do not react with reactive dyes and easily wash out of finished textile • However, more expensive than starch • 50% of global alginate market • Food Industry • Thickening properties useful in sauces, syrups, and toppings. • Improves texture and body of yogurt • Prevents sedimentation of pulp in drinks • Maintains suspension of cocoa in chocolate milk • Paper Industry • Better oil resistance and gloss • Welding rods • Coatings are applied to control immediate vicinity of weld • Temp., O2 , H2 availability • Mold making materials • Dentistry, prosthetics, lifecasting • Mold release agents • Insolubility in nonaqueous solvents
Immobilization of Biocatalysts • Entrapment of enzymes and cells • Allow penetration of substance to be converted • Biocatalysts must be concentrated and recoverable • Conversion of glucose to fructose • Conversion of starch to ethanol • Continuous production of yogurt • Pharmaceutical and Medical Uses • Stable fibers are excellent dressing material • Do not adhere to wound • Tablet disintegrant • Dietary Product • Swelling properties in stomach give “full” feeling • Controlled release of medicinal drugs • Active ingredient placed in bead and slowly released when exposed environment • Biomedical • Immunoisolation of cells • Prevents formation of fibrous capsule • Islet encapsulation for treatment of diabetes • Alginate microspheres for controlled release of chemicals • Magnetically modulated release • Employed in artificial skin • Scaffolds • Ca2+ crosslinking increases mechanical strength • 3D Tissue Constructs encapsulating functional cells
Applications of alginates are based on 3 properties: • Increase viscosity of aqueous solutions • Ability to form gel • Ability to form films of and fibers • Pharmaceutical and Medical Uses • Stable fibers are excellent dressing material • Do not adhere to wound • Tablet disintegrant • Dietary Product • Swelling properties in stomach give “full” feeling • Controlled release of medicinal drugs • Active ingredient placed in bead and slowly released when exposed environment • Textile Industry • Thickeners for paste containing dyes • Do not react with reactive dyes and easily wash out of finished textile • However, more expensive than starch • 50% of global alginate market www.snapalginate.com/index2.htm
Paper Industry • Better oil resistance and gloss • Welding rods • Coatings are applied to control immediate vicinity of weld • Temp., O2 , H2 availability • Mold making materials • Dentistry, prosthetics, lifecasting • Mold release agents • Insolubility in nonaqueous solvents http://www.craftcellar.co.uk/index1.html • Food Industry • Thickening properties useful in sauces, syrups, and toppings. • Improves texture and body of yogurt • Prevents sedimentation of pulp in drinks • Maintains suspension of cocoa in chocolate milk http://www.marconews.com/news/2007/Aug/23/algae_found_more_just_seaweed/
Immobilization of Biocatalysts • Entrapment of enzymes and cells • Allow penetration of substance to be converted • Biocatalysts must be concentrated and recoverable • Conversion of glucose to fructose • Conversion of starch to ethanol • Continuous production of yogurt Glucose http://www.starsandseas.com/SAS_Images/SAS_chem_images/fructose_helix.jpg Fructose http://www.alcohol-stuff.co.uk/images/beer-mug.JPG http://home.hia.no/~stephens/glucose.gif http://www.foodmall.org/images/yoplait-yogurt_7.jpg
Biomedical • Immunoisolation of cells • Prevents formation of fibrous capsule • Islet encapsulation for treatment of diabetes • Alginate microspheres for controlled release of chemicals • Magnetically modulated release • Employed in artificial skin • Scaffolds • Ca2+ crosslinking increases mechanical strength • 3D Tissue Constructs encapsulating functional cells Chang R, Nam J, and Sun W. Direct cell writing of 3D microorgan for in vitro pharmacokinetic model. Tissue Engineering 14, 157, 2008. http://www.liebertonline.com/doi/pdf/10.1089/ten.2006.0175?cookieSet=1 Chang et al
Morch, Yrr A. "Novel Alginate Microcapsules for Cell Therapy." Thesis. Norwegian University of Science and Technology