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結構生物學期末報告

結構生物學期末報告. 生技所 一年級 M93360027 鄭育欣. 期末主題. @ 原因 : 因為 TmAFP 在阻止冰晶生長上比起魚類的 AFP 還有效 100 倍 。 所以我想找有關“ 海水魚”抗凍蛋白的結構和這篇結構加以比較 。 目的 : 從結構中是否可以看出為什麼 昆蟲的 AFP 效率較好的可能原因 。 @ TmAFP structure 中有水分子嗎 ?? @ TmAFP 的多重序列比對 @ 抗凍蛋白會出現在人體中嗎 ??. TmAFP structure. 尋找魚類的 AFP. 尋找魚類的 AFP.

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結構生物學期末報告

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  1. 結構生物學期末報告 生技所 一年級 M93360027 鄭育欣

  2. 期末主題 @ 原因 : 因為TmAFP在阻止冰晶生長上比起魚類的AFP還有效100倍。所以我想找有關“ 海水魚”抗凍蛋白的結構和這篇結構加以比較。目的 : 從結構中是否可以看出為什麼昆蟲的AFP效率較好的可能原因。 @ TmAFP structure 中有水分子嗎?? @ TmAFP的多重序列比對 @ 抗凍蛋白會出現在人體中嗎??

  3. TmAFP structure

  4. 尋找魚類的AFP

  5. 尋找魚類的AFP Structure Explorer - 1WFA @ Ice-binding structure and mechanism of an antifreeze protein from winter flounder. @ Nature 375 pp. 427 (1995) @ Sicheri, F., Yang, D. S. @ Pseudopleuronectes americanus 美國黃蓋鰈 Structure Explorer - 1UCS @ The Refined Crystal Structure of an Eel Pout Type III Antifreeze Protein Rd1 at 0.62-(Angstrom) Resolution Reveals Structural Microheterogeneity of Protein and Solvation @ Biophys.J. 84 pp. 1228 (2003) @ Ko, T.-P., Robinson, H., Gao, Y.-G., Cheng, C.-H. C., Devries, A. L., Wang, A. H.-J.: @ Lycodichthys dearborni 南極黏魚

  6. PaAFP

  7. LdAFP

  8. LdAFP

  9. LdAFP

  10. LdAFP

  11. LdAFP

  12. 抗凍機制比較

  13. 抗凍機制比較

  14. 這些protein structures有水分子嗎?? TmAFP >1EZG:A THERMAL HYSTERESIS PROTEIN ISOFORM YL-1 • QCTGGADCTSCTGACTGCGNCPNAVTCTNSQHCVKANTCTGSTDCNTAQTCTNSKDCFEA • NTCTDSTNCYKATACTNSSGCPGH • >1EZG:B THERMAL HYSTERESIS PROTEIN ISOFORM YL-1 • QCTGGADCTSCTGACTGCGNCPNAVTCTNSQHCVKANTCTGSTDCNTAQTCTNSKDCFEA • NTCTDSTNCYKATACTNSSGCPGH PaAFP • >1WFA:A ANTIFREEZE PROTEIN ISOFORM HPLC6 (4 DEGREES C) - CHAIN A • DTASDAAAAAALTAANAKAAAELTAANAAAAAAATARX • >1WFA:B ANTIFREEZE PROTEIN ISOFORM HPLC6 (4 DEGREES C) - CHAIN B • DTASDAAAAAALTAANAKAAAELTAANAAAAAAATARX LdAFP • >1UCS:A ANTIFREEZE PEPTIDE RD1 • NKASVVANQLIPINTALTLIMMKAEVVTPMGIPAEEIPKLVGMQVNRAVPLGTTLMPDMV • KNYE

  15. Mutile sequence aligment

  16. 抗凍蛋白會出現在人體中嗎??

  17. ~ Thanks ~

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