CHOLEDOCHOLITHIASIS

1. CHOLEDOCHOLITHIASIS Aswad Habeeb Hameed Al-Obeidy FICMS GE & Hep

2. CHOLEDOCHOLITHIASIS • Defined as the occurrence of stones in the bile ducts • May remain asymptomatic for years • Are known to pass silently into the duodenum, perhaps frequently • Tend to present as life-threatening complications such as cholangitis and acute pancreatitis • Should be followed by some type of intervention to remove the stones

3. Etiology • May pass from the gallbladder into the CBD or can form de novo in the duct • All gallstones from one patient, whether from the gallbladder or CBD, are of one type, either cholesterol or pigment • Cholesterol stones form only in the gallbladder, and any cholesterol stones found in the CBD must have migrated there from the gallbladder • Black pigment stones, which are associated with old age, hemolysis, alcoholism, and cirrhosis, also form in the gallbladder and only rarely migrate into the CBD • The majority of pigment stones in the CBD are the softer brown pigment stones

4. Etiology • Fifteen percent of patients with gallbladder stones also have CBD stones • Conversely, of patients with ductal stones, 95% also have gallbladder stones • Formation of pigment stones in the CBD is also a late complication of endoscopic sphincterotomy • In a study of the long-term consequences of endoscopic sphincterotomy in more than 400 patients, the cumulative frequency of recurrent CBD stones was 12% • All the recurrent stones were of the brown pigment type, irrespective of the chemical composition of the original gallstones

5. Clinical Features • Acute obstruction usually causes biliary pain and jaundice • Obstruction that develops gradually over several months may manifest initially as pruritus or jaundice alone • If bacteria proliferate, life-threatening cholangitis may result

6. Physical findings • The physical findings are usually normal if obstruction of the CBD is intermittent • Mild to moderate jaundice may be noted when obstruction has been present for several days to a few weeks • Deep jaundice without pain, particularly with a palpable gallbladder (Courvoisier's sign), suggests neoplastic obstruction of the CBD, even when the patient has stones in the gallbladder • With long-standing obstruction, secondary biliary cirrhosis may result, leading to physical findings of chronic liver disease

7. Laboratory Finding • Results of laboratory studies may be the only clue to the presence of choledocholithiasis • With bile duct obstruction, serum bilirubin and alkaline phosphatase levels both increase. • Bilirubin accumulates in serum because of blocked excretion, • whereas alkaline phosphatase levels rise because of increased synthesis of the enzyme by the canalicular epithelium. • The rise in the alkaline phosphatase level is more rapid than and precedes the rise in bilirubin level • The absolute height of the serum bilirubin level is proportional to the extent of obstruction, but the height of the alkaline phosphatase level bears no relationship to either the extent of obstruction or its cause • The serum bilirubin level is typically in the range of 2 to 5 mg/dLand rarely exceeds 12 mg/dL. • Transient “spikes” in serum aminotransferase or amylase levels suggest passage of a common duct stone into the duodenum. • The overall sensitivity of liver biochemical testing for detecting choledocholithiasis is reported to be 94%; • serum levels of gamma glutamyl transpeptidase are elevated most commonly but maynot be assessed in clinical practice

8. Diagnosis • Ultrasonography actually visualizes CBD stones in only about 50% of cases whereas dilatation of the CBD to a diameter greater than 6 mm is seen in about 75% of cases • EUS has excluded or confirmed choledocholithiasis with sensitivity and specificity rates of approximately 98% as compared with ERCP • ERCP is the standard method for the diagnosis and therapy of CBD stones, with sensitivity and specificity rates of approximately 95% • EUS and MRCP, should be performed first when the clinical probability of choledocholithiasis is low • Percutaneous transhepatic cholangiography (percutaneous THC) • laparoscopic ultrasonography may be as accurate as surgical cholangiography in detecting CBD stones

9. Differential Diagnosis • Biliary pain is always in the differential diagnosis in patients with an intact gallbladder. The presence of jaundice or abnormal liver biochemical results strongly points to the bile duct rather than the gallbladder • Malignant obstruction of the bile duct or obstruction from a choledochal cyst may be indistinguishable clinically • Acute passive congestion of the liver, associated with cardiac decompensation, may cause intense RUQ pain, tenderness, and even jaundice with serum bilirubin levels higher than 10 mg/dL • Acute viral hepatitis rarely may cause severe RUQ pain with tenderness and fever • Acquired immunodeficiency syndrome (AIDS)–associated cholangiopathy and papillary stenosis

10. Treatment • Choledocholithiasis warrants treatment in nearly all cases • CBD stones discovered at the time of a laparoscopic cholecystectomy present a dilemma to the surgeon. The operation can be converted to an open cholecystectomy with CBD exploration, but this approach results in greater morbidity and a more prolonged hospital stay • Alternatively, the laparoscopic cholecystectomy can be carried out as planned, and the patient can return for ERCP with removal of the CBD stones. Such an approach, if successful, cures the disease but runs the risk of necessitating a third procedure, namely a CBD exploration, if the stones cannot be removed at ERCP • In especially high-risk patients, endoscopic removal of CBD stones may be performed without cholecystectomy. This approach is particularly appropriate for elderly patients with other severe illnesses. Studies indicate that cholecystectomy is required subsequently for recurrent symptoms in only 10% of patients.