IMAGE GALLERY

1. In Vivo Imaging Facility Notre Dame Integrated Imaging Facility OVERVIEW: In Vivo Imaging Facility LIST OF SERVICES IMAGE GALLERY Multispectral Fluorescence Imaging Bioluminescence Specimen Radiography Bone Density Measurement Planar Radioisotopic Imaging X-ray computed tomography (Spring ’09) Bioluminescent prostate cell detection Tumor imaging with a fluorescent probe APPLICATIONS Tumor Imaging Infection Imaging Gene Expression Bone Growth/Density Multimodal Imaging Kinetic measurements of various biological phenomena (In Vitro and In Vivo) Our Mission is to Provide State of the Art Technology to Non-Invasively Image Disease Models and Biological Processes in Living Systems The In Vivo Imaging Facility provides a non-invasive approach to observe various disease and biological models in living systems. We currently have equipment to detect all luminescent genetic reporters (luciferase, GFP, RFP, β-gal, etc.) and fluorescent probes ranging from green to near infrared. Our multispectral capabilities permit unmixing of spectrally overlapping fluorophores in the same sample. We also offer planar X-ray for digital radiographic imaging of various types of specimens. Our technology is also applicable to a wide range of In Vitro samples including gels, blots, 96-well plates, and numerous others. Our goal is to train and empower users to independently utilize the facility and its resources. Contact the Managing Director, Dr. Matt Leevy, for training, consultation, and/or experimental service. Multispectral fluorescence imaging of quantum dots X-ray image of a mouse injected IV with a contrast agent 1 cm CONTACT INFORMATION W. Matthew Leevy, Ph.D. Managing Director Multimodal In Vivo Imaging Facility University of Notre Dame Office Location: 003 Galvin Hall Office Phone: 574-631-1683 Cell Phone: 314-494-6747 E-mail: wleevy@nd.edu X-ray image of an ~4 cm trout In vivo detection of S. aureus bacterial infection with a fluorescent probe X-ray image of a fly X-ray and fluorescence imaging of murine GI tract