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Thalidomide - Oncothal 100mg tablet online | Anticancerdrugs

Thalidomide, sold under the brand name Oncothal 100mg, among others, is an immunomodulatory drug and the prototype of the Oncothal 100mg class of drugs.

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Thalidomide - Oncothal 100mg tablet online | Anticancerdrugs

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  1. ONCOTHAL 100MG Oncothal 100mg is a piperidinyl isoindole basically introduced as a non-barbiturate hypnotic but detached from the market due to teratogenic effects. It has been renewing and indicated for several immunological and inflammatory disorders. Oncothal displays immunosuppressive and anti-angiogenic activity. It prevents release of tumor necrosis factor-alpha from monocytes and modulates another cytokine action. INDICATION : Oncothal 100mg is used for the acute treatment of the cutaneousmanifestations of moderate to severe erythema nodosum leprosum (ENL). Oncothal 100mg in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma. Oncothal 100mg is not used as monotherapy for such ENL treatment in the presence of moderate to severe neuritis. Oncothal 100mg is also used as maintenance therapy for prohibition and suppression of the cutaneous manifestations of ENL relapsed. MECHANISM OF ACTION : The immunologic effects of thalidomide vary considerably under different conditions but may be related to overthrow of exaggerated tumor necrosis factor-alpha (TNF-a) production and down-modulation of selected cell surface adhesion molecules involved in leukocyte migration. For example, patients getting of thalidomide has been resulted to reduce circulating levels of TNF-a in patients with ENL, however , it has also been shown to increase plasma TNF-a levels in HIV-seropositive patients. Since cancer therapy, the medication may work as a VEGF inhibitor. PHARMACOKINETIC : Absorption :

  2. Time to peak plasma concentration is 2.9 to 5.7 hours Distribution : Plasma protein binding is 55% and 66% for the (+) R and (-) S enantiomers, respectively. Metabolism : Metabolized hepatically by enzymes of the cytochrome P450 enzyme system. Elimination : Excreted in the urine as unchanged drug is less than 0.7% of the dose. Half-life of thalidomide is 5 to 7 hours. PRECAUTIONS : Avoid taking regimens that may cause drowsiness without first consulting your health care provider. Also avoid alcohol. For both men and women use contraceptives, and do not conceive a child (get pregnant) while taking Oncothal. serious, life-threatening birth defects may have reported with even one 50 mg dose. Methods of contraception has two types, such as latex condoms and spermicides, are required. Priorinitiating Oncothal treatment, make sure to inform doctor about any other medications you are taking (containing prescription, over-the-counter, vitamins, herbal remedies, etc.). Avoid taking aspirin, or products including aspirin untilthe doctor especially permits this. For women of childbearing potential should use contraception 4 weeks before you can startOncothal. The manufacturer needed you to take a pregnancy test every month before you initiate a new prescription of thalidomide. This is to confirm that you or your significant other is not pregnant. Consult with your doctor when you may safely become pregnant or conceive a child after treatment. Do not breast feed while taking this medication.

  3. Drug – Drug Interaction : Concomitant use of Oncothal 100mg with opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants may lead to additive sedative effect. Interaction of Oncothal 100mg with cardiovascular medication will cause an additive bradycardic effect and should be used with caution. Combination with bortezomib, amiodarone, cisplatin, docetaxel, paclitaxel, vincristine etc will cause peripheral neuropathy and should be used with caution. Unknown condition when concomitant use of hormonal contraceptives further increases the risk of thromboembolism with Oncothal. Pregnancy : Pregnancy category X: Oncothal may cause risk to fetal when administer to a pregnant woman. This drug should notadminister to a pregnant woman or a woman who aims to become pregnant. If a woman becomes pregnant during Oncothal therapy, the drug must be discontinued immediately, and the woman given correct counselling. Contraindications : Pregnancy category X: Oncothal may cause risk to fetal when administer to a pregnant woman. This drug should note administer to a pregnant woman or a woman who aims to become pregnant. If a woman becomes pregnant during Oncothal therapy, the drug must be discontinued immediately, and the woman given correct counselling. Missed Dose : Take the dose immediately before next dose duration. Next dose time reaches then left off the missed dose and continue regular schedule. Avoid taking double dose at same time. Please consult the doctor for further information. For More Information : Call us : +91-97890 77748 Mail to : info@blueberrypharma.com

  4. Domain : https://blueberrypharma.com/oncothal-100mg.php

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