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Zecyte 500mg |Abiraterone Acetate | Apple pharmaceuticals

Zecyte 500mg is a type of classification belongs to antineoplastic and it contain active ingredients of Abiraterone acetate. Which is an antiandrogen medication is indicated for the treatment of prostate cancer @ Apple Pharmaceuticals<br>

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Zecyte 500mg |Abiraterone Acetate | Apple pharmaceuticals

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  1. Description : Zecyte 500mg is a type of classification belongs to antineoplastic and it contain active ingredients of Abiraterone acetate. Which is an antiandrogen medication is indicated for the treatment of prostate cancer which spread to other parts of the body. Zecyte 500mg tablets is also used along with prednisone, a steroid. In clinical trials Zecyte 500mg is used for prostate cancer and advanced breast cancer. Usage : Zecyte 500mg is an inhibitor of CYP17 which is used to treats the patients with metastatic castration-resistant prostate cancer, The patient has received earlier chemotherapy with docetaxel combination with prednisone and in failure of androgen deprivation treatment. The patient clinically not used for chemotherapy with prednisone or prednisolone will preferred treatment with metastatic CRPC in adult men. Dosage and administration : • No food should be consumed for at least 2 hours before and at least 1 hour after the dose of ZECYTE Tablets is taken. • Zecyte should be swallowed whole with water. • Do not crush or chew the tablets. • Prescribed dose ofZecyte 500mg tablets is 1,000 mg, Zecyte 500mg given 4 doses orally once in a day (OD). • Zecyte tablets in Combination with prednisone 5 mg administered orally twice daily. • Zecyte Tablets administrated on an empty stomach. Mechanism Of Action :

  2. A type of steroidal enzyme inhibitor CYP17A1 (17 alpha- hydroxylase/C17,20 lyase) is known as abiraterone acetate which is an orally active and It interfere with CYP17A1 in a selective and invariable manner through covalent binding mechanism. An enzyme CYP17A1 which catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. Particularly, abiraterone prevents the conversion of 17- hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to reduce serum levels of testosterone and other androgens. Precautions : • Do not take other medications, i.e prescription, over-the-counter, vitamins, herbal remedies, etc be sure to inform the doctors before the treatment. Aspirin do not administering and products containing aspirin till doctor particularily allow the drug. • In women Abiraterone acetate is not currently used. if administrating abiraterone acetate by woman, Do not get pregnant and breastfeeding not recommended during treatment • Unknown process of abiraterone acetate is eliminated in semen, hence do not use condom and another method of birth control by men during treatment and for 1 week following the last dose of abiraterone acetate. Drug Interaction • Effects of Abiraterone on drug metabolizing enzymes • Abiraterone is a hepatic drug-metabolizing inhibitor CYP2D6, when substrates (dextromethorphan) of it is co administrated with Abiraterone will increases the

  3. Cmaxand AUC dextromethorphan. • Drugs that inhibits or induce CYP3A4 • Abiraterone interaction with strong CYP3A4inhibitors or inducers, the pharmacokinetics of Abiraterone is not evaluated properily, so avoid or use with caution while abiterone therapy. Side Effects : Patients taking Abiraterone acetate have following side effects are common in >30% occurring : • Retention of fluid • Triglycerides increased • Increased liver enzyme Less common side effects of Abiraterone 10-29% occurring: • Joint discomfort • Hypokalemia • Swelling of hands/ feets • Myalgia • Hypophosphatemia • UTI Pregnancy : Category X: Abiraterone acetate is not recommended for womens, It will cause fetal harm when administered to pregnant women. During treatment if women become pregnant, immediately stop the drug and give counseling to the women. Lactation : Abiraterone acetate is not used in women excretion in human milk is unknown and the drug effects in the nursing infant is unknown. Storage :

  4. Store the medicine in tight, closed container and kept at room temperature, away from excess heat and moisture. Keep out of reach of children’s Store at 200C – 250C Pregnant women should not handle without protection e.g gloves. Missed Dose If missed a dose take have it as soon you remember, if time for next dose reach, then leave the missed dose and follow regular schedule. Do not take two dose at a time. TAKE ADVICE FROM THE DOCTOR. For More Information : Call us : +91- 9987711567 Mail to : applepharmaceutical@gmail.com Domain : http://anti-cancer-drugs.com/zecyte-500mg.php

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