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Marc Cohen-Renée Larocque Global Health Research Initiative

The Global Health Research Initiative - GHRI. Marc Cohen-Renée Larocque Global Health Research Initiative Afri -Can Forum, January 18, 2013-Entebbe, Uganda. AGENDA The Global Health Research Initiative ( GHRI ) GHRI programs Overview of the Canadian HIV Vaccine Initiative ( CHVI )

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Marc Cohen-Renée Larocque Global Health Research Initiative

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  1. The Global Health Research Initiative - GHRI MarcCohen-RenéeLarocque Global Health Research Initiative Afri-Can Forum,January 18, 2013-Entebbe, Uganda

  2. AGENDA The Global Health Research Initiative (GHRI) GHRI programs Overview of the Canadian HIV Vaccine Initiative (CHVI) GHRI and CHVI – where is the link? Q&A

  3. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A GHRI was founded in 2001. It is a partnership of three Canadian government agencies: Canadian Institutes of Health Research (CIHR) Canadian International Development Agency (CIDA) International Development Research Centre (IDRC) IDRC is the “host” agency

  4. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A GHRI grants support 3 complementary areas of action: research (a range of multi-disciplinary approaches, including action-research, participatory research, RCTs, etc.) strengthening research capacity (learning-by-doing) knowledge translation (teams with decision-makers)

  5. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A GHRI: 2001-2016 Where we work

  6. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A GHRI Programs $1.055M 2008-2013 $26.6M 2006-2012 $16.7M 2009-2014 Teasdale-Corti CIII-Haiti $4M HIV/AIDS Prevention Trials Capacity Building $5.9M 2008-2014 GHRI contribution 2010-2013 Africa Health System Initiative-RES EcoEID in SE Asia

  7. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A Ecohealth Emerging Infectious Diseases Program in Southeast Asia 3 projects 7 countries 2010-2013 4M$ GHRI contribution Where we work

  8. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A African Health Systems Initiative – Support to African Research Partnerships 10 projects 7 countries 2008-2014 5.9M$ Where we work

  9. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A HIV/AIDS Prevention Trials Capacity Building Grants, phase II 9 projects 30 countries 2009-2014 16.7M$ Where we work

  10. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A

  11. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A HIV/AIDS Prevention Trials Capacity Building Grant Phase2 Program offered in partnership with the Canadian HIV Vaccine Initiative (CHVI) through a financial contribution from the Canadian International Development Agency (CIDA) and the International Development Research Centre (IDRC)

  12. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A The Canadian HIV Vaccine Initiative (CHVI) Government of Canada (CIDA, CIHR, HC, IC, PHAC) and Bill & Melinda Gates Foundation partnership Initiated in 2007 to help accelerate efforts to develop a safe, effective, affordable and globally accessible HIV vaccine

  13. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A CHVI objectives are: To advance the basic science of HIV vaccine in Canada, and low-and-middle-income countries To support the translation of basic sciences discoveries into clinical trials To address the enabling conditions (regulatory, community) To advance the development of related technologies To improve the efficacy and effectiveness of HIV Prevention of Mother-to-Child (PMTCT) services in low-and-middle-income countries

  14. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A IC HC CIHR PHAC CIDA CHVI Bill and Melinda Gates Foundation ACO Translation of sciences discoveries in clinical trial Advance the basic sciences of HIV CIHR grants GHRI/CIDA grants Team Grant: HIV/AIDS Vaccine Discovery and Social Research 5 Projects GHRI HIV Prevention Trials Capacity Building Grants 9 Projects

  15. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A Newsletter: Third issue

  16. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A Booklet… available today!

  17. Overview of CHVI Program Overview Collaboration Lessons Q&A Thank you

  18. GHRI GHRI Programs Overview of CHVI GHRI-CHVI? Q&A Questions?

  19. Overview of CHVI Program Overview Collaboration Lessons Q&A Program objectives Strengthen the capacity and leadership skills of African researchers and institutions to undertake prevention trials with special focus on innovations in HIV/AIDS prevention, particularly HIV vaccines Support collaboration and networking of African researchers and research users in HIV/AIDS prevention trials related research and policy development Advance the collaboration and networking of Canadian and African researchers and institutions in global HIV/AIDS prevention trials efforts

  20. Overview of CHVI Program Overview Collaboration Lessons Q&A Program Design Belongs to: CHVI objective to support the translation of basic science discoveries into clinical trials African-led research teams Grants: up to CA$1.8M over 4 years Comprehensive approach to strengthening research capacity: trial administration and management, ethics reviews processes, securing funding, engaging communities and policy-makers, publishing results

  21. Overview of CHVI Program Overview Collaboration Lessons Q&A Complementarygrants Up to CA$50 000 to support scientific excellence in HIV prevention research and capacity building of young researchers through learning-by-doing KAVI O. Anzala, Nadia MusimbiChanzu CANSSA S. Allen, T. Ndung’u, William Kilembe, MammekwaMokgoro CAPT D. Wilson, L. Balfour, P. Kaleebu, B. Cameron, RushaGovender, George Miiro Nigeria A. Abimiku, G. Garber, K. Corace, Susan Yilme TanZamBo R. Musonda, M. Wainberg, SimaniGaseitsiwe, Balthazar Nyombi, Mike Chaponda

  22. Overview of CHVI Program Overview Collaboration Lessons Q&A Project teams build capacities in: Good Clinical Practice Laboratory techniques Social and Biomedical Sciences Regulatoryprocesses Advocacy Project teams use differentapproaches Short and long term trainings Mentoring Learning by doing Project teams audiences include Researchers Decison-makers Communitiesand media

  23. Overview of CHVI Program Overview Collaboration Lessons Q&A CIHR Programmatic Grants to tackle health and health equity • Yassi, Engelbrecht (Workplace South-Africa) “This GHRI-funded project was likely an important factor in leveraging a 5-year research programmatic grant from CIHR (Health Equity program) for our collaborative team, and the partnerships forged during this GHRI initiative will be crucial in the operationalizing of this research program”. Yassi A., Engelbrecht M., First Annual Report, 2011 • Alary, Zannou(BENIN)

  24. Overview of CHVI Program Overview Collaboration Lessons Q&A Projects teams The Kenya AIDS Vaccine Initiative (KAVI): A Centre of Excellence for HIV Vaccine/Prevention Trials in East Africa-KENYA Canada-Africa Prevention Trials (CAPT) Network – Proposal to Build African Capacity for HIV/AIDS Prevention Trials-UGANDA, SOUTH AFRICA, KENYA TanZamBo Capacity Building for HIV Prevention Research Network-BOTSWANA, TANZANIA, ZAMBIA

  25. Overview of CHVI Program Overview Collaboration Lessons Q&A Projects teams ADAPT2 (African Development of AIDS Prevention Trials capacities, second phase)-SOUTH AFRICA, NAMIBIA, BOTSWANA, LESOTHO, MALAWI, MOZAMBIQUE, SWAZILAND, TANZANIA, ZAMBIA, ZIMBABWE West African Platform for HIV Intervention Research (WAPHIR)-SENEGAL, THE GAMBIA, GUINEA BISSAU The Canada – sub-Saharan Africa (CANSSA) HIV/AIDS network: Building capacity for prevention trials research and clinical care in Africa- SOUTH AFRICA

  26. Overview of CHVI Program Overview Collaboration Lessons Q&A Projects teams Creating a common platform for HIV vaccine research and HIV care and treatment program- NIGERIA Closed: Preparingfor HIV preventionrandomized control trials- BENIN Closed: Building capacity for HIV prevention trials in the health care workplace- SOUTH AFRICA

  27. Canada-AfricaPreventionTrials Network Assist in developing 8 African HIV prevention research centres Build sustainable leadership through training opportunities Provide internal communications and facilitation of collaborative research initiatives

  28. Kenya AIDS Vaccine Initiative (KAVI) Establish a Centre of excellence for training health care professionals in East Africa on vaccine trials Enhance lab capacity and capacity of local REBs/institutional administrators to handle vaccine development Build vaccine literacy/ acceptance among local communities, policy makers and other stakeholders

  29. AfricanDevelopment of AIDS Prevention Trials (ADAPT2) Increase capacity to conduct HIV prevention trials in SADC countries through short methods courses Apply multi-country RCT logistical framework; build capacity to train students in methodology Increase capacity of African decision-makers to use research

  30. Canada-sub-SaharanAfrica HIV/AIDS network (CANSSA) African HIV/AIDS network of excellence Knowledge translation and training in clinical, biomedical and sociological research Clinical and laboratory infrastructure and establishment of pilot projects

  31. West African Platform for HIV Intervention Research (WAPHIR) Strengthen lab capacity through improved immunology/virology techniques, and a clinical trial support training program with a lab platform

  32. Nigeria team Creation of internationally certified HIV clinical research site Ability to conduct HIV vaccine clinical trials at the highest standard and build supportive lab capacity Build capacity in: clinical, research ethics, regulation community mobilization, risk cohort development vaccine cohort development

  33. TanZamBoCapacity Building for HIV Prevention Research Network (TanZamBo) Capacity building of researchers to conduct HIV/AIDS prevention trials and research, including vaccines Institutional capacity building, improving expertise and technology Support for MSc training in clinical research/biostatistics and postdocs who manage the projects with PIs

  34. Benin – Preparing for HIV preventionrandomized control trials- Closed Capacity building for Bénin PhD students in Québec Maintaining l'Unité de Recherche en Prévention du VIH (UREPIV), Universitéd'Abomey-Calavi, to support researchers and community workers Maintaining sex worker cohort in Cotonou

  35. South Africa – Building capacity for HIV prevention trials in the health care workplace-Closed • Certificate program to train health care workers in research • design, implementation and evaluation of workplace-based interventions for HIV & TB prevention

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