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Nephrology Case Presentation

Nephrology Case Presentation. Douglas Stahura DO 17 September 2002. “Set the appropriate learning environment”. Learning Objectives. Rhabdomyolysis Definition Acute renal failure Pathophysiology Clinical presentation Treatment Case studies. Case 1.

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Nephrology Case Presentation

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  1. Nephrology Case Presentation Douglas Stahura DO 17 September 2002

  2. “Set the appropriate learning environment”

  3. Learning Objectives • Rhabdomyolysis • Definition • Acute renal failure • Pathophysiology • Clinical presentation • Treatment • Case studies

  4. Case 1 • 56 y/o CF presented with Acute MI, developed pulseless right lower extremity. Normal renal function.

  5. Case 2 • 48 y/o CM found “down” after 3 days in his kitchen. Unresponsive, hypotensive, anuric. • Na 185, Glucose 2500, CPK 18,000

  6. Case 3 • 62 y/o “gentleman” found by police in park unresponsive and smelling of alcohol. • Thin, cachetic, hypotensive. • Bun 22, Creatinine = 7.6, CPK=22,000

  7. Case 4 • 19 y/o AAF presents with weakness and falls. 3rd ED visit in 7 weeks. • K=2.8, CPK=19,000, BUN=55, Creatinine=6.2

  8. Case 5 • 18 y/o CM presents by squad from local arena where “The Who” reunion tour kicked off. “Festival seating” caused a rush at the gate. • Pt has extensive bruising and crush injuries.

  9. Case 6 • Earthquake levels 4 story apartment building trapping 18 people. The injured present to trauma stations from 1 to 30 hours after the collapse.

  10. Case 7 • 76 y/o AAM presents with nausea and anorexia x2 weeks. Now feels week. Dark urine. • PMH: CAD, DM2, HTN • BUN=110, creatinine=8.2, CPK 42,000

  11. Case 8 • 27 y/o Air Force Captain presents on Monday with red discolored urine that started Sunday.

  12. Case 9 • 17 y/o AAF presents from home by EMS in seizure. Further efforts require 90 minutes to gain control of her convulsions.

  13. Case Studies • All the above cases were complicated by acute renal failure induced by endogenous toxicity to myoglobin released by damage to muscle cells – rhabdomyolysis

  14. Definition • Rhabdomyolysis • Muscle necrosis • Release of intracellular constituents of muscle cells • Severity • Asymptomatic enzyme elevation • Life threatening enzyme elevation, electrolyte disturbances, acute renal failure

  15. Myoglobinuric Acute Renal Failure • Classic description from 1941 when Bywaters described “crush syndrome” in which victims of the London Blitz trapped and crushed in bombed buildings would, despite rescue, die of uremia soon afterwards

  16. Myoglobinuric Acute Renal Failure • Myoglobin – heme containing protein • Freely filtered at the glomerulus • Proximal endocytic reabsorption is overwhelmed • Delivery to distal tubule is increased

  17. Myoglobinuric Acute Renal Failure • Acute Tubular Necrosis (ATN) is provoked • Intrarenal vasoconstriction by scavenging NO • Third spacing of fluids leads to hypovolemia • Obstructing tubular casts, especially in acidic urine • Iron may be directly toxic

  18. Clinical Findings • Muscle pain is variable • Urinalysis • Dipstick strongly positive for blood • Few if any RBC’s on microscopic • Color may be red-brown-black • CPK elevated • General correlation of CPK with ARF (>16,000)

  19. Clinical Findings • Creatinine • Serum levels high out of proportion to BUN • Electrolytes • Potassium, Uric acid, Lactic acid, phosphorous released by necrotic myocytes • Hypocalcemia due to calcium-phosphate precipitation

  20. Treatment • Fluid replacement • Saline infusion @ 1.5 L/hr • Forced diuresis +/- urinary alkalinization • Goal is suggested as 300 cc/hr • .45 NS + 10 gm Mannitol + 40 Meq NaHCO3

  21. Treatment • Mannitol • Diuresis maintains high flow rate through tubules • Possible free radical scavenging effect • Alkalinization • May provide theoretical advantage in preventing conversion of myoglobin to methemoglobin • May cause precipitation of calcium phosphate in urinary system

  22. Treatment • Role of acute dialysis • Does not remove myoglobin • May be needed to control the severity of hyperkalemia • CVVHDF may not be able to manage

  23. Case 1 • 56 y/o CF presented with Acute MI, developed pulseless right lower extremity. Normal renal function. • Pt has occluded aorto-bifem bypass, pulseless, cold, pale-to-blue, painful leg.

  24. Case 2 • 48 y/o CM found “down” after 3 days in his kitchen. Unresponsive, hypotensive, anuric. • Na 185, Glucose 2500, CPK 18,000 • Pt lay on the floor in his kitchen >72 hours in one position. Has muscle breakdown on right side of head, shoulder, arm, hip leg.

  25. Case 3 • 62 y/o “gentleman” found by police in park unresponsive and smelling of alcohol. • Thin, cachetic, hypotensive. Bun 22, Creatinine = 7.6, CPK=22,000 • Chronic alcoholics have pre-existing hypophosphatemia • Increased renal losses, damage to proximal epi • Decreased GI intake/absorption • Muscle depletion of phosphorous

  26. Case 3 • Superimposed second metabolic insult result in hypophosphatemic rhabdo (ATP theory) • Respiratory alkalosis – prolonged intense hyperventilation as seen with EtOH withdrawal • Increase in pH activates glycolysis increasing phosphorylated compounds within the cell. Serum phosphorous falls precipitously

  27. Case 4 • 19 y/o AAF presents with weakness and falls. 3rd ED visit in 7 weeks. • K=2.8, CPK=19,000, BUN=55, Creatinine=6.2 • Hypokalemic periodic paralysis can be associated with hypophosphatemia.

  28. Case 5 • 18 y/o CM presents by squad from local arena where “The Who” reunion tour kicked off. “Festival seating” caused a rush at the gate. • Pt has extensive bruising and crush injuries. • Classic crush syndrome, can be associated with compartment syndrome

  29. Case 6 • Earthquake levels 4 story apartment building trapping 18 people. The injured present to trauma stations from 1 to 30 hours after the collapse. • Classic crush syndrome • Fluids initiated in the field to replete volume and force diuresis may be of significant benefit even before a pt is freed, or crushed limb is reperfused.

  30. Case 7 • 76 y/o AAM presents with nausea and anorexia x2 weeks. Now feels week. Dark urine. • PMH: CAD, DM2, HTN • BUN=110, creatinine=8.2, CPK 42,000 • Pt has dysmetabolic syndrome • Hyperlipidemia treated with statin and fibrate

  31. Case 8 • 27 y/o Air Force Captain presents on Monday with red discolored urine that started Sunday. • Previously healthy, no meds, no previous urinary complaints (hematuria/proteinuria) • You happen to remember that WPAFB held annual Air Force marathon on Saturday.

  32. Case 9 • 17 y/o AAF presents from home by EMS in seizure. Further efforts require 90 minutes to gain control of her convulsions. • Intense electrical stimulation of muscles can cause rhabdo

  33. References • Comprehesive Clinical Nephrology, Johnson, Feehally, London, UK,2000 • Harrison’s Principles of Internal Medicine 14th, Fauci, New York, NY 1998 • The Kidney 6th, Brenner and Rector,Philadelphia, PA 2000

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