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Post-Infectious Glomerulonephritis in a 12-Year-Old Male

This case involves a 12-year-old male presenting with vomiting, facial swelling, fatigue, oliguria, and diplopia. He was diagnosed with post-infectious glomerulonephritis and started on dialysis. Biopsy showed moderate to strong coarsely granular capillary loop staining for IgG, C3, kappa, and lambda.

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Post-Infectious Glomerulonephritis in a 12-Year-Old Male

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  1. U05-20470

  2. History is that of a 12 y/o male presenting with a few day history of vomiting, facial swelling, fatigue and oliguria. Hypertensive only at times of vomiting. Also c/o diplopia. No rash, or joint symptoms. Did have a low grade fever prior to coming in. No complaints of sore throat. Might have had some skin lesions/scabs from pruritus. On admission, found to be in ARF with urea 48, Cr > 600, oliguria, normal Hb, and enlarged echogenic kidneys. Serology +ve for low C3 (<0.10), antiDNAseB titre elevated, throat swab +ve for Strep. Dialysis started on day 2 of admission. Biopsied to confirm diagnosis.

  3. Immunofluorescence • IgG – Moderate to strong coarsely granular capillary loop staining • IgA – Negative • IgM – Negative • C3 – Moderate vascular staining, strong coarsely granular capillary loop staining • C1q – Negative • Kappa – Mild to moderate coarsely granular capillary loop staining • Lambda – Mild to moderate coarsely granular capillary loop staining • Fibrinogen – mild interstitial staining • Albumin – mild hyaline droplet change in tubular cytoplasm

  4. IgG – coarsely granular capillary loop staining

  5. C3 - coarsely granular capillary loop staining

  6. Kappa - coarsely granular capillary loop staining

  7. Lambda -coarsely granular capillary loop staining

  8. Fibrin – mild interstitial

  9. Albumin – mild hyaline droplet change

  10. Diagnosis • Post infectious Glomerulonephritis

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