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Understanding Aspartic Acid and Asparagine Metabolism

Learn about the metabolism of aspartic acid and asparagine, their roles in various pathways, synthesis, clinical applications, and more.

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Understanding Aspartic Acid and Asparagine Metabolism

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  1. ASPARTIC ACID AND ASPARAGINE METABOLISM By- Maya Yadav Roll No.-46 HIMS MBBS Ist Year

  2. Aspartic Acid • Non-essential amino acid. • Glucogenic amino acid. • Acidic amino acid.

  3. Source • Our cell can make aspartic acid so it can’t be typically needed as part of our diet. • But it can be supplemented through other sources in diet. • Animal source- • egg, meat and dairy product • Plant source- • Barley,oat, millet, white rice and amaranthus

  4. Synthesis • Transamination- Aspartate are synthesized by transfer of amino group to the alpha keto acid oxaloacetate.

  5. By Asparagine • Asparagine is converted to aspartate with the help of enzyme asparaginase.

  6. Metabolism N1 is correct, N3 is wrong

  7. Role in Urea cycle • Aspartate donates one amino group for the synthesis of urea. • Aspartate forms a connecting link between urea cycle and TCA cycle via oxaloacetate.

  8. Role in Purine metabolism • It is utilized in the synthesis of purine at N1 and NH2 at sixth position. NH₂

  9. Role in Pyrimidine metabolism In pyrimidine synthesis N3,C4,C5 and C6 atoms are synthesized from aspartate. 6 5 4 N1 correct

  10. Role in Glucogenic pathway • The carbon skeleton of aspartate can enter the glucogenic pathway as fumarate. • Citrulline + Aspartate Arginine + Fumarate

  11. Synthesis of Aspartame • Aspartic acid react with phenylalanine form aspartame which is a artificial sweetener. • It is a mild irritant of the nervous system. Aspartic acid + phenylalanine Aspartame

  12. Help in synthesis of another amino acid • Amino acid like asparagine, arginine, lysine , methionine,threoinine and isoleucine are synthesized from aspartic acid.

  13. Function of Aspartic acid • Aspartic acid act as a regulator in synthesis and release of hormone and neurochemicals. • In pituitary glands, aspartic acid stimulates the secretion of following hormones – • Prolactin • LH • Growth hormone • Aspartic acid act as a chelating agent. Chelate the minerals to make easier them to assimilate,digest and utilize as calcium, magnesium and potassium aspartate. • Aspartic acid increases the neurological activity.

  14. Role in transport of reducing equivalent • NADH that synthesized from glycolysis is present in cytosol. • Mitochondrial membrane is impermeable for the transport of the above . • So a specific shuttle is present over the mitochondrial membrane called malate aspartate shuttle for this transport.

  15. Clinical Applications • Chronic Fatigue Syndrome • Exercise recovery and performance .

  16. Asparagine • It is so named because it is isolated from asparagus. • It was first discovered amino acid. • Vauquelin and Robiquet in 1906 isolated asparagine. • It was shown to be a member of all proteins by ManayathDarmodaran in 1932.

  17. ASPARAGINE IS- Non essential amino acid Glucogenic amino acid

  18. Synthesis • From Aspartate • Aspartate reacts with ammonia to form asparagine.

  19. Catabolism • Hydrolysis of asparagine-

  20. Function • Help in development and function of brain. • Important role in the synthesis of ammonia. • Has a role in glycosylation for protein structure and function. • Role in protein biosynthesis. • Ammonia trapping in the brain.

  21. Clinical applications of asparagine • Excess intake of asparagine can cause leukemia and lymphomas. • Enzyme asparaginase act as a anticancerous agent use for the treatment of leukemia and lymphomas. • Asparaginase convert excess asparagine into aspartic acid.

  22. THANK YOU

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