Get To Know EUK-134 Quickly In 10 Minutes-APICDMO

1. Get To Know EUK-134 Quickly In 10 Minutes  What Is EUK-134(CAS:81065-76-1)? EUK 134(CAS:81065-76-1) is a synthetic manganese-porphyrin complex which has been documented to act as a scavenger for oxidative species such as hydrogen peroxide, peroxynitrite and superoxide. This product is different from the common antioxidants. It has excellent self regeneration antioxidant performance and can protect lipids and proteins. EUK-134 can inhibit MMP activity and protect and repair DNA. EUK-134 is a unique active molecule with the potential of superoxide dismutase and catalase. One of the main differences between EUK-134 and other approved antioxidants is that EUK-134 can regenerate through molecular construction during the free radical scavenging cycle.  How Does EUK-134 Works? EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.  EUK-134 Main Functiaon EUK 134 is an antioxidant component of cutting-edge technology. One of the biggest characteristics of EUK 134 is that it can regenerate repeatedly, with antioxidant effect up to 12 hours. In addition to its own antioxidant, it also has www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

2. the function of damaging the structure of free radicals, which can make other antioxidant components more quickly and effectively achieve the effect of neutralizing free radicals. The value of EUK 134 in skin care is that it can protect lipid and protein from oxidative damage, and its toxicity is much lower than that of similar compounds. It is generally used as an antioxidant additive in high-end cosmetics, and also has anti-inflammatory and anti-aging effects.  EUK-134 Application Protect against DNA damage DNA repair Anti-inflammatory anti-oxidation Sunscreen care supplement Anti-irritation Fight oxidative stress Anti-stress         【 【Reference】 】 [1] Rong, Y., Doctrow, S. R., Tocco, G., & Baudry, M. (1999). EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proceedings of the National Academy of Sciences, 96(17), 9897-9902. [2] A Rosenthal, R., Fish, B., P Hill, R., D Huffman, K., Lazarova, Z., Mahmood, J., … & R Doctrow, S. (2011). Salen Mn complexes mitigate radiation injury in normal tissues. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 11(4), 359-372. [3] Kim, J. H., & Lawler, J. M. (2012). Amplification of proinflammatory phenotype, Free Radical Biology and Medicine, 52(9), 1597-1606. [4] Howard, M. D., Greineder, C. F., Hood, E. D., & Muzykantov, V. R. (2014). Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation. Journal of controlled release, 177, 34-41. www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com