GREENER CHEMICAL PRODUCTS AND PROCESSES STANDARD

1. GREENER CHEMICAL PRODUCTS AND PROCESSES STANDARD GC Chemical Characteristics Task Group presentation to Joint Committee on Greener Chemical Products and Processes American Chemical Society Green Chemistry Institute Washington DC October 20, 2009

2. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Approach • Developed list of chemical characteristics • Categories • Subcategories • Criteria, potential route of exposure • Examples of tests to inform the criteria • Matrix of information needed based on intended application, (e.g., closed process, industrial operations, dispersive use) • Developed list of filter criteria • Applied filter to chemical criteria to determine if appropriate for this standard at this time

3. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Filter Criteria • 1. Is there an established definition? Definable? • 2. Is there a validated test? Measurable? • or • 3. Is there a generally accepted methodology, calculation, model? • 4. Is the test/method commonly done?

4. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP 3-Tiered Approach 3. Potential Future Considerations No mention in this Standard Characteristics that may be added to this Standard at some future time (e.g., size– nanomaterials; genomics 2. State-of-the-Science Statement Include text statement in thisStandard Evolving characteristics – do not yet fulfill our Filter Criteria (e.g., 14-Day Worm, Endocrine Disrupters) 1. Chemical Characteristics List as a Chemical Characteristic for evaluation in this Standard Characteristics that fulfill 3 of our 4 Filter Criteria

5. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories & Subcategories Subcategories A. Physical Safety Fire Reactivity Special B. Human Health Acute Chronic • Ecological Impact • (includes long-term impacts used • in life cycle analyses) Air Water Soil

6. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories & Criteria A. Physical Safety Subcategories Criteria Fire Reactivity Special Flammability Explosivity Corrosive (metal) Oxidizer Water-Reactive Radioactive

7. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests B. Human Health Example Tests Subcategories Criteria Acute Inhalation Dermal Oral IDLH STEL/Ceiling LC50 (inhalation) Odor threshold * LD50 Skin Irritation Eye Irritation LD50 (oral) ARfD * Only applies to small number of chemicals

8. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests B. Human Health Example Tests Subcategories Criteria Chronic Subchronic Toxicity Repeat dose (28- or 90-day) Reproductive If triggered by repeatDevelopmental Effects dose or QSAR Carcinogenicity If on IARC or NTP list or if triggered by repeat dose Neurotoxicity If triggered by repeat dose Sensitization (I, D) Chronic Inhalation RfC, TLV Chronic oral RfD (oral) Mutagenicity Bacterial reverse mutation assay, in vitro cytogenetics

9. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests C. Ecological Impact Subcategories Criteria Example Tests Air Persistence Bioaccumulation Exposure/Fate Toxicity Long-term Effects Persistence (Air) Half-Life N/A – No Air Test(s) Available Fugacity with Volatilization (VP) N/A – No Air Test(s) Available Acidification Global Warming Potential Ozone-Depleting Potential Photochemical Smog

10. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests C. Ecological Impact Subcategories Criteria Example Tests Water Persistence Bioaccumulation Exposure/Fate Toxicity Long-term Effects EPA Persistence (Water) Half-Life, or Biodegradability & Hydrolysis Half-Lives Log Kow, or BCF, or BAF Fugacity with Water Solubility Fish LC50 Daphnae LC50 Green Algae EC50 Eutrophication Theoretical Oxygen Demand, or Biological Oxygen Demand, or Chemical Oxygen Demand

11. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests C. Ecological Impact Subcategories Criteria Example Tests Soil Persistence Bioaccumulation Exposure/Fate Long-term Effects Persistence (Soil) Half-Life N/A – No Soil Test(s) Available Fugacity with Koc Groundwater Mobility Factor

12. STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP SUMMARY • Standard needs to be practical, usable, and provide relevant information • Group has developed a recommended list of chemical characteristics that: • Have established definitions, • Are measurable using validated tests or are calculable using standard, accepted methods, and • Have tests that are done commonly. • Provide relevant information from a supplier to his customer.