Phase II Center for Chemical Innovation

1. Phase II Center for Chemical Innovation A www.nsfcentc.org

2. Catalysis Green Chemistry Uncatalyzed Catalyzed E Starting materials Products (only good chemicals!) (Even better chemicals!) Catalysis can “green” the production of basic chemicals, polymers, materials, fuels and pharmaceuticals less energy atom-efficient - decrease waste streams less toxic reagents cost effective!

3. Catalysis - Tremendous Economic and Environmental Impact Centers for Chemical Innovation (CCI) is a new National Science Foundation (NSF) program to support centers that will be focused on novel research centered in the chemical sciences and aimed at solving high-risk, long-term problems of large scope and impact. They will have a high probability of producing transformative research likely to lead to innovations, i.e. research results that can lead to new processes, materials or devices that will enhance economic competitiveness. Center for Enabling New Technologies through Catalysis (CENTC) established in 2007 is the first Phase II CCI

4. Center for Enabling New Technologies through Catalysis (CENTC) - A History • NSF Phase I Chemical Bonding Center (CBC), the Center for the Activation and Transformation of Strong Bonds (CATSB) was established in September 2004 • 12 principal investigators (PIs) from 8 institutions across the US, Additional Phase I PI added December 2005 • $500,000/yr from NSF for three years…ended 8/31/07 • NSF Phase II Center for Chemical Innovation (CCI), the Center for Enabling New Technologies through Catalysis (CENTC) was established in August of 2007 • 16 investigators at 11 institutions from across the US • $ 3,000,000/yr from NSF for five years

5. CENTC Principal Investigators and Institutions

6. CENTC is Much Larger than 16 PIs • Much larger than 16 PIs….graduate students, postdocs, collaborators, undergraduates, high school students and teachers, Advisory Board members, industrial affiliates…… • Strong industrial relationships key to parlaying CENTC breakthroughs into new and useful technologies

7. Current areas of CENTC interest • Selective Alkane Oxidation … direct use of alkanes • Alkane Metathesis … coal/shale/biomass to diesel • Biomass conversion… fuels and chemicals production • Novel reactions for organic synthesis… pharmaceuticals and materials

8. Alkane Metathesis CENTC PIs Goldman (Rutgers) and Brookhart (UNC) developed tandem catalyst system for AM (Science, 2006, 312, 257) two different catalysts alkanedehydrogenation olefin metathesis or Re2O7 / Al2O3 Scott (UCSB) and Schrock (MIT) brought into CENTC to collaborate on olefin metathesis catalysts olefinhydrogenation

9. Fischer- Tropsch alkane metathesis Diesel (C9-18) C4-C8 (not desired) GAS (C1-C3) HIGH-MW Alkane Metathesis - Why? n-alkanes (C9-19) are theideal transportation fuel: Clean-burning FT diesel fuel is ca. 30 - 40% more efficient than gasoline. FT diesel fuel extremely low (0-5-ppm) sulfur, aromatics, and toxics. FT diesel could replace 100% of fuel supply; replacing conventional diesel (22%) with FT diesel will have an enormous effect on air quality (especially for particulates)

10. Current CENTC Research 2008 Anti-Markovnikov Hydroamination Of Alkenes Water Oxidation Glycerol Deoxygenation Disassembly of Lignocellulose Metalloenzyme Evolution for Organic Synthesis Direct Amination of Arenes Methane Oligomerization Electrophilic Oxidation Catalysts New Anodes for Alkane/Alcohol Fuel Cells Alkane Metathesis Dehydroaromatization of n-Alkanes Carbohydrates to Chemicals 12/4/2008

11. CENTC Collaboration and Communication • Collaborating PIs and their co-workers communicate on a regular basis via email, instant messaging (IM), telephone, conference calls, and video chats • Cybertools for collaboration/communication • IChat (Mac)/AOL-IM (PC), Skype and Access Grid

12. Annual Center Meeting Everyone involved: PIs, student and postdoctoral co-workers, Advisory Board members and Industrial Affiliates • Formal progress reporting/discussion and “reality check” with Industrial Affiliates and Scientific Advisory Board • PIs, co-workers and AB members propose and consider future directions, new personnel, project terminations Annual Meeting, Seattle, September 2007 16 PIs, 22 graduate students, 11 postdocs, a faculty collaborator, 4 Advisory Board members, 4 staff, a NSF Program Officer, 7 industrial affiliate representatives

13. Education within CENTC Graduate students and postdoctoral associates benefit from: • Unique collaborative environment • Closer view of project development • See ideas develop into active projects by participation in • brainstorming sessions • Enhanced breadth of education • Range of research projects, techniques and styles Range of research areas - Homogeneous catalysis, heterogeneous catalysis, biocatalysis, and the assembly of tandem and cascade catalytic processes and petrochemicals, renewable feedstocks and pharmaceuticals - all discussed in the same meeting

14. Reaching outside of CENTC CENTC Summer School on Organometallic Catalysis - July 21-25, 2008 60 participants (115 applicants) 7 faculty 7 PD and 45 GS 1 Industry 19 instructors 12 academic 4 industry 2 national labs Presentations and videos will be made available on CENTC website…. www.nsfcentc.org

15. CENTC Industrial Affiliates Program Benefits of Membership: • Attend CENTC Annual Meetings to hear about new results and participate in round-table discussions. • Determine early on whether CENTC fundamental discoveries are of interest to you. • Provide input into the scientific directions of the Center. • Interact with CENTC personnel, including graduate students and postdoctoral fellows. • Have the opportunity to participate in CENTC diversity, education and outreach programs.