1 / 12

What is Factor V-Leiden?

What is Factor V-Leiden?. A Disorder that causes abnormal blood clots Directly causes Thrombophilia Forms blood clots which blocks blood cells. Causes of Factor V-Leiden. A mutation in the F5 Gene The F5 Gene creates the Factor V The Factor V Protein causes blood clots

argyle
Download Presentation

What is Factor V-Leiden?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. What is Factor V-Leiden? • A Disorder that causes abnormal blood clots • Directly causes Thrombophilia • Forms blood clots which blocks blood cells.

  2. Causes of Factor V-Leiden • A mutation in the F5 Gene • The F5 Gene creates the Factor V • The Factor V Protein causes blood clots • Blood clots are a defense towards injuries • Mutated Factor V Proteins cause abnormal clots

  3. Symptoms of Factor V-Leiden • •Indications that show Factor V-Leiden: • * Pain, Significant Swelling, Redness, Warmth • *= commonly affects legs,ankles, and feet • • Pulmonary Embolism(blocks blood flow to heart)

  4. Incidences Concerning Factor V-Leiden • This is a very common genetic disease • Mostly European populations carry this disease • 3-8% of Europeans carry a copy • 1 in 5000 people carries two copies • Much less common in other populations

  5. Inheritance • Mostly depends on the amount of copies • Babies from two carrier parents have risk • With more people born with copies, more infected

  6. Diagnosis for Factor V-Leiden • Activated protein C resistance Test • - Resistance to this protein shows mutation. • Genetic Test • - Done to confirm the results of APC

  7. Treatment of Factor V-Leiden • Anticoagulant(blood thinning) • Heparin and Warfarin • - Heparin: quicker than warfarin(Injection) • - Warfarin: Pill form, causes birth defects

  8. Discovery of Factor V-Leiden • Discovered in 1943 • Added to the Morawitz theory • Was a dogma to the theory

  9. Support for Factor V-Leiden • Thrombophilia Awareness Project • Many Doctors in California for Factor V-Leiden

  10. Promotion • Elizabeth Varga (Certified Genetic Counselor)

  11. Bibliography • http://www.mayoclinic.com/ • http://www.fvleiden.org • http://ghr.nlm.nih.gov/condition/factor-v-leiden-thrombophilia • http://www.netdoctor.co.uk/diseases/facts/factorv.htm • http://onlinelibrary.wiley.com/doi/10.1046/j.1538-7836.2003.00043.x/full • http://www.wellsphere.com/genetics-article/to-celebrate-dvt-awareness-month/346050

More Related