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Antiplatelets and PPIs: Controversies and Choices of Agents

Antiplatelets and PPIs: Controversies and Choices of Agents. Thank you for taking the pre-assessment. To assess learning, these questions will be repeated at the end of the activity. Statin and Clopidogrel PK/PD Interaction Did Not Translate to Clinical Effect.

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Antiplatelets and PPIs: Controversies and Choices of Agents

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  1. Antiplatelets and PPIs: Controversies and Choices of Agents

  2. Thank you for taking the pre-assessment. To assess learning, these questions will be repeated at the end of the activity.

  3. Statin and Clopidogrel PK/PD Interaction Did Not Translate to Clinical Effect

  4. COGENT: Omeprazole Had No Effect on CV Events in Prospective, Randomized Trial

  5. TRILOGY ACS Study Design

  6. TRILOGY ACS: Overall PPI Use Constant Over Study Period

  7. COGENT: Omeprazole and Clopidogrel in a Prospective, Randomized Trial

  8. TRILOGY ACS: PPI Use Did Not Affect Platelet Function (N = 2049 < 75 years)

  9. TRILOGY ACS: Primary End Point by PPI Use (N = 7243, < 75 years)

  10. TRILOGY ACS: PPI Interaction With Clopidogrel (N = 5858, < 75 years)

  11. TRILOGY ACS: PPI Users at Higher Baseline Risk

  12. TRILOGY ACS: No Difference in TIMI Major Bleeding (N = 7243, < 75 years)

  13. Additional Slides on This Topic

  14. ASA and Risk of GI Bleeding -- Meta-Analyses

  15. Prevention of Recurrent GI Bleeding: Aspirin + PPI Better Than Clopidogrel Alone

  16. PPIs Reduce GI Complications in Patients on Aspirin

  17. PPIs Reduce GI Complications in Patients on Aspirin

  18. GI Bleeding Increases Mortality

  19. Potential PPI Interaction With Formation of Thienopyridine Active Metabolites

  20. Omeprazole Attenuates the PD Effects of Clopidogrel

  21. FDA and EMEA Statements

  22. FDA Warning: PPIs and Clopidogrel

  23. Consensus Document

  24. PLATO: PPI Users Higher Baseline Risk

  25. Abbreviations

  26. Abbreviations (cont)

  27. References

  28. References (cont)

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