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Center for Human Genetics Genetic Analysis Manual

Center for Human Genetics Genetic Analysis Manual. Carol Haynes April 7, 2009. Summary. Cumulative over 25 years of genetic analysis Updated as new methods are introduced Provides training opportunities for new statistical analysts New web interface allows browsing, searching, keywords.

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Center for Human Genetics Genetic Analysis Manual

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  1. Center for Human GeneticsGenetic Analysis Manual Carol Haynes April 7, 2009

  2. Summary • Cumulative over 25 years of genetic analysis • Updated as new methods are introduced • Provides training opportunities for new statistical analysts • New web interface allows browsing, searching, keywords

  3. Link to the CHG On-line Analysis Manual

  4. View powerpoint presentations on the fundamentals of genetic analysis by experienced geneticists

  5. Case Study 1: Before writing a grant, determine if your genetic study sample has the power to detect the a significant effect Read about why power calculations are necessary and how to interpret significance levels Learn to use SOLAR for QTL power calculation in family-based studies

  6. Learn about case-control power calculation tools

  7. Case 2: Methods section in grant submission: . . . Click on a topic, then check Contents tab for location and information Check index for key word

  8. Or use the search function. . . Then click on a topic to view the information, check the contents tab to find the location

  9. Case 3: Understand terms used in example paper Shah SH, Freedman NJ, Zhang L, Crosslin, DR, Stone DH, et al. 2009 Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis. PLoS Genet 5(1): e1000318. doi:10.1371/journal.pgen.1000318 Shah SH, Freedman NJ, Zhang L, Crosslin, DR, Stone DH, et al. 2009 Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis. PLoS Genet 5(1): e1000318. doi:10.1371/journal.pgen.1000318 Download link Use index to find listings regarding OSA Reference Software co-developed by current CHG faculty member, Beth Hauser

  10. Case 3: con’t Mouse over blue highlighted words to see definition A human disease or condition characterized by multiple genetic and environmental risk factors, examples include diabetes, cardiovascular disease and cancer. Use search option to find entries with any or all key words

  11. Case 3: con’t Shah SH, Freedman NJ, Zhang L, Crosslin, DR, Stone DH, et al. 2009 Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis. PLoS Genet 5(1): e1000318. doi:10.1371/journal.pgen.1000318 Software developed at CHG, link to download provided Index entry References Command line arguments

  12. Case 3: con’t Shah SH, Freedman NJ, Zhang L, Crosslin, DR, Stone DH, et al. 2009 Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis. PLoS Genet 5(1): e1000318. doi:10.1371/journal.pgen.1000318 Review the contents for family based analyses, including family-based association

  13. GRASP team members • Carol Haynes – Senior project manager/programmer • Sarah Nelson – Science writer/data management • Beth Rusnak – Webmaster • Beth Hauser - Director

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