Drugs affecting the respiratory system

1. Drugs affecting the respiratory system Lilley, Harrington,Snyder Chapters 35 &36

2. Objectives Antihistamines Decongestants Antitussives Expectorants Bronchodilators Beta adrenergic agonist Anticholinergics Antileukotriene agents Corticosteroids Mast cell stablizers

3. Understanding the Common Cold Most caused by viral infection (rhinovirus or influenza virus�the �flu�) Virus invades tissues (mucosa) of upper respiratory tract, causing upper respiratory infection (URI)

4. Treatment of the Common Cold Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is symptomatic only, not curative Symptomatic treatment does not eliminate the causative pathogen

5. Treatment of the Common Cold (cont�d) Difficult to identify whether cause is viral or bacterial Treatment is �empiric therapy,� treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified

6. Antihistamines Drugs that directly compete with histamine for specific receptor sites Two histamine receptors H1 (histamine1) H2 (histamine2)

7. Antihistamines (cont�d) H1 histamine receptor- found on smooth muscle, endothelium, and central nervous system tissue; causes vasodilation, bronchoconstriction, smooth muscle activation, and separation of endothelia cellss (responsible for hives), and pain and itching due to insect stings H1 antagonists are commonly referred to as antihistamines Antihistamines have several properties Antihistaminic Anticholinergic Sedative

8. Antihistamines (cont�d) H2 blockers or H2 antagonists Used to reduce gastric acid in PUD Examples: cimetidine, ranitidine, famotidine

9. Antihistamines (cont�d) 10% to 20% of general population is sensitive to various environmental allergies Histamine-mediated disorders Allergic rhinitis (hay fever, mould and dust allergies) Anaphylaxis Angioneurotic edema Drug fevers Insect bite reactions Urticaria (itching)

10. Antihistamines: Mechanism of Action Block action of histamine at the H1 receptor sites Compete with histamine for binding at unoccupied receptors Cannot push histamine off the receptor if already bound

11. Antihistamines: Mechanism of Action (cont�d) The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine stimulation Vasodilation Increased GI and respiratory secretions Increased capillary permeability

12. Antihistamines: Mechanism of Action (cont�d) More effective in preventing the actions of histamine rather than reversing them Should be given early in treatment, before all the histamine binds to the receptors

13. Antihistamines: Indications Management of: Nasal allergies Seasonal or perennial allergic rhinitis (hay fever) Allergic reactions Motion sickness Sleep disorders

14. Antihistamines: Indications (cont�d) Also used to relieve symptoms associated with the common cold Sneezing, runny nose Palliative treatment, not curative

15. Antihistamines: Side effects Anticholinergic (drying) effects, most common Dry mouth Difficulty urinating Constipation Changes in vision Drowsiness Mild drowsiness to deep sleep

16. Antihistamines: Two Types Traditional Nonsedating/peripherally acting

17. Traditional Antihistamines Older Work both peripherally and centrally Have anticholinergic effects, making them more effective than nonsedating agents in some cases Examples: Benedryl (diphenhydramine)

18. Nonsedating/Peripherally Acting Antihistamines Developed to eliminate unwanted side effects, mainly sedation Work peripherally to block the actions of histamine; thus, fewer CNS side effects Longer duration of action (increases compliance) Examples: reactine, allegra

19. Antihistamines:Nursing Implications Gather data about the condition or allergic reaction that required treatment; also assess for drug allergies Contraindicated in the presence of acute asthma attacks and lower respiratory diseases Use with caution in increased intraocular pressure, cardiac or renal disease, hypertension, asthma, COPD, peptic ulcer disease, BPH, or pregnancy

20. Antihistamines:Nursing Implications (cont�d) Instruct clients to report excessive sedation, confusion, or hypotension Avoid driving or operating heavy machinery, and do not consume alcohol or other CNS depressants Do not take these medications with other prescribed or OTC medications without checking with prescriber

21. Antihistamines:Nursing Implications (cont�d) Best tolerated when taken with meals�reduces GI upset If dry mouth occurs, teach client to perform frequent mouth care, chew gum, or suck on hard candy to ease discomfort Monitor for intended therapeutic effects

22. Decongestants

23. Nasal Congestion Excessive nasal secretions Inflamed and swollen nasal mucosa Primary causes Allergies Upper respiratory infections (common cold)

24. Decongestants: Types (cont�d) Two dosage forms Oral Inhaled/topically applied to the nasal membranes

25. Oral Decongestants Prolonged decongestant effects, but delayed onset Effect less potent than topical No rebound congestion Exclusively adrenergics Example: pseudoephedrine, Sinutab, Dristan, Tylenol cold, Sudafed

26. Topical Nasal Decongestants Topical adrenergics Prompt onset Potent Sustained use over several days causes rebound congestion, making the condition worse Eg:DRISTAN* DECONGESTANT NASAL MIST (SOLUTION)COMPOSITION:Each 1 mL of solution contains:������� Phenylephrine HCl������� 5 mg������� Pheniramine Maleate������� 2 mg

27. Topical Nasal Decongestants (cont�d) Adrenergics desoxyephedrine phenylephrine Intranasal steroids beclomethasone dipropionate flunisolide fluticasone

28. Nasal Decongestants:Mechanism of Action Site of action: blood vessels surrounding nasal sinuses Adrenergics Constrict small blood vessels that supply URI structures As a result these tissues shrink, and nasal secretions in the swollen mucous membranes are better able to drain Nasal stuffiness is relieved

29. Nasal Decongestants:Mechanism of Action (cont�d) Site of action: blood vessels surrounding nasal sinuses Nasal steroids Anti-inflammatory effect Work to turn off the immune system cells involved in the inflammatory response Decreased inflammation results in decreased congestion Nasal stuffiness is relieved

30. Nasal Decongestants: Indications Relief of nasal congestion associated with: Acute or chronic rhinitis Common cold Sinusitis Hay fever Other allergies

31. Nasal Decongestants: Indications (cont�d) May also be used to reduce swelling of the nasal passage and facilitate visualization of the nasal/pharyngeal membranes before surgery or diagnostic procedures

32. Nasal Decongestants: Side Effects Adrenergics Steroids Nervousness Local mucosal dryness Insomnia and irritation Palpitations Tremors (systemic effects due to adrenergic stimulation of theheart, blood vessels, and CNS)

33. Nasal Decongestants:Nursing Implications Decongestants may cause hypertension, palpitations, and CNS stimulation�avoid in clients with these conditions Clients on medication therapy for hypertension should check with their physician before taking OTC decongestants Assess for drug allergies

34. Nasal Decongestants:Nursing Implications (cont�d) Clients should avoid caffeine and caffeine-containing products Report a fever, cough, or other symptoms lasting longer than a week Monitor for intended therapeutic effects

35. Antitussives

36. Cough Physiology Respiratory secretions and foreign objects are naturally removed by the: Cough reflex Induces coughing and expectoration Initiated by irritation of sensory receptors in the respiratory tract

37. Two Basic Types of Cough Productive cough Congested, removes excessive secretions Nonproductive cough Dry cough

38. Coughing Most of the time, coughing is beneficial Removes excessive secretions Removes potentially harmful foreign substances In some situations, coughing can be harmful, such as after hernia repair surgery

39. Coughing Most of the time, coughing is beneficial Removes excessive secretions Removes potentially harmful foreign substances In some situations, coughing can be harmful, such as after hernia repair surgery

40. Antitussives: Definition Drugs used to stop or reduce coughing Opioid and nonopioid(narcotic and nonnarcotic) Used only for nonproductive coughs!

41. Antitussives: Mechanism of Action Opioids Suppress the cough reflex by direct action on the cough centre in the medulla Examples: codeine hydrocodone

42. Antitussives: Mechanism of Action (cont�d) Nonopioids Suppress the cough reflex by numbing the stretch receptors in the respiratory tract and preventing the cough reflex from being stimulated Examples: Dextromethorphan, Nyquil, Robitussin

43. Antitussives: Indications Used to stop the cough reflex when the cough is nonproductive and/or harmful

44. Antitussives: Side Effects Dextromethorphan Dizziness, drowsiness, nausea Opioids Sedation, nausea, vomiting, lightheadedness, constipation

45. Antitussive Agents:Nursing Implications Perform respiratory and cough assessment, and assess for allergies Instruct clients to avoid driving or operating heavy equipment due to possible sedation, drowsiness, or dizziness If taking chewable tablets or lozenges, do not drink liquids for 30 to 35 minutes afterward

46. Antitussive Agents:Nursing Implications (cont�d) Report any of the following symptoms to the caregiver Cough that lasts more than a week A persistent headache Fever Rash Antitussive agents are for nonproductive coughs Monitor for intended therapeutic effects

47. Expectorants

48. Expectorants: Definition Drugs that aid in the expectoration (removal) of mucus Reduce the viscosity of secretions Disintegrate and thin secretions

49. Expectorants: Mechanisms of Action Direct stimulation Reflex stimulation Final result: thinner mucus that is easier to remove

50. Expectorants: Mechanism of Action (cont�d) Reflex stimulation Agent causes irritation of the GI tract Loosening and thinning of respiratory tract secretions occur in response to this irritation Example: guaifenesin Direct stimulation The secretory glands are stimulated directly to increase their production of respiratory tract fluids Examples: iodine-containing products such as iodinated glycerol and potassium iodide

51. Expectorants: Drug Effects By loosening and thinning sputum and bronchial secretions, the tendency to cough is indirectly diminished

52. Expectorants: Indications Used for the relief of nonproductive coughs associated with:

53. Expectorants:Nursing Implications Expectorants should be used with caution in the elderly or those with asthma or respiratory insufficiency Clients taking expectorants should receive more fluids, if permitted, to help loosen and liquefy secretions Report a fever, cough, or other symptoms lasting longer than a week Monitor for intended therapeutic effects

54. CHAPTER 36Bronchodilators and Other Respiratory Agents

57. Diseases of the Lower Respiratory Tract Bronchial asthma Emphysema Chronic bronchitis COPD Cystic fibrosis Acute respiratory distress syndrome

58. Agents Used to Treat Asthma Long-term control Antileukotrienes Cromoglycate Inhaled steroids Long-acting beta2-agonists Quick relief Intravenous systemic corticosteroids Short-acting inhaled beta2-agonists ipratropium nedocromil theophylline

59. Bronchodilators and Respiratory Agents Bronchodilators Xanthine derivatives Beta-adrenergic agonists Anticholinergics Antileukotrienes Corticosteroids Mast cell stabilizers

60. Bronchodilators: Xanthine Derivatives Plant alkaloids: caffeine, theobromine, and theophylline Only theophylline is used as a bronchodilator Examples: aminophylline Theophylline Slo-Bid� Uniphyl�

61. Xanthine Derivatives: Drug Effects Cause bronchodilation by relaxing smooth muscles of the airways Result: relief of bronchospasm and greater airflow into and out of the lungs Also cause CNS stimulation Slow onset action and are mostly used for prevention Aminophylline(Status asthmaticus)

62. Xanthine Derivatives: Drug Effects (cont�d) Also cause cardiovascular stimulation: increased force of contraction and increased HR, resulting in increased cardiac output and increased blood flow to the kidneys (diuretic effect)

63. Xanthine Derivatives: Indications Dilation of airways in asthmas, chronic bronchitis, and emphysema Mild to moderate cases of acute asthma Adjunct agent in the management of COPD

64. Xanthine Derivatives: Side Effects Nausea, vomiting, anorexia Gastroesophageal reflux during sleep Sinus tachycardia, extrasystole, palpitations, ventricular dysrhythmias Transient increased urination

65. Nursing Implications: Xanthine Derivatives Contraindications: history of PUD or GI disorders Cautious use: cardiac disease

66. Bronchodilators: Beta-Agonists Large group, sympathomimetics Used during acute phase of asthmatic attacks Quickly reduce airway constriction and restore normal airflow Stimulate beta2-adrenergic receptors throughout the lungs

67. Bronchodilators: Beta-Agonists (cont�d) Three types Nonselective adrenergics Stimulate alpha-, beta1- (cardiac), and beta2- (respiratory) receptors Example: epinephrine Nonselective beta-adrenergics Stimulate both beta1- and beta2-receptors Example: isoproterenol Selective beta2 drugs Stimulate only beta2-receptors Example: salbutamol

68. Beta-Agonists: Indications Relief of bronchospasm related to asthma, bronchitis, and other pulmonary diseases Useful in treatment of acute attacks as well as prevention

69. Beta-Agonists: Side Effects Beta2 (salbutamol) Hypotension OR hypertension Vascular headaches Tremor Contraindicated: clients with allergies, tachyarythmias, severe cardiac disease

70. Nursing Implications Encourage clients to take measures that promote a generally good state of health in order to prevent, relieve, or decrease symptoms of COPD Avoid exposure to conditions that precipitate bronchospasms (allergens, smoking, stress, air pollutants) Adequate fluid intake Compliance with medical treatment Avoid excessive fatigue, heat, extremes in temperature, caffeine

71. Nursing Implications (cont�d) Perform a thorough assessment before beginning therapy, including: Skin colour Baseline vital signs Respirations (should be <12 or >24 breaths/min) Respiratory assessment, including SaO2 Sputum production Allergies History of respiratory problems Other medications

72. Nursing Implications (cont�d) Teach clients to take bronchodilators exactly as prescribed Ensure that clients know how to use inhalers and MDIs, and have the clients demonstrate use of devices Monitor for side effects

73. Nursing Implications (cont�d) Monitor for therapeutic effects Decreased dyspnea Decreased wheezing, restlessness, and anxiety Improved respiratory patterns with return to normal rate and quality Improved activity tolerance Decreased symptoms and increased ease of breathing

74. Anticholinergics: Mechanism of Action Acetylcholine (ACh) causes bronchial constriction and narrowing of the airways Anticholinergics bind to the ACh receptors, preventing ACh from binding Result: bronchoconstriction is prevented, airways dilate

75. Anticholinergics Atrovent (ipratropium bromide) is the only anticholinergic used for respiratory disease Slow and prolonged action Used to prevent bronchoconstriction NOT used for acute asthma exacerbations! Combivent (salbutamol/ipratroprium)

76. Anticholinergics (cont�d) Side effects: Dry mouth or throat Gastrointestinal distress Headache Coughing Anxiety No known drug interactions

77. Antileukotrienes Also called leukotriene receptor antagonists (LRTAs) Newer class of asthma medications Three subcategories of agents

78. Antileukotrienes (cont�d) Currently available agents: Montelukast (sold as Singulair�) Zafirlukast (sold as Accolate�)

79. Antileukotrienes: Mechanism of Action Leukotrienes are substances released when a trigger, such as cat hair or dust, starts a series of chemical reactions in the body Leukotrienes cause inflammation, bronchoconstriction, and mucus production Result: coughing, wheezing, shortnessof breath

80. Antileukotrienes: Mechanism of Action (cont�d) Antileukotriene agents prevent leukotrienes from attaching to receptors on cells in the lungs and in circulation Inflammation in the lungs is blocked, and asthma symptoms are relieved

81. Antileukotrienes: Drug Effects By blocking leukotrienes: Prevent smooth muscle contraction of the bronchial airways Decrease mucus secretion Prevent vascular permeability Decrease neutrophil and leukocyte infiltration to the lungs, preventing inflammation

82. Antileukotrienes: Indications Prophylaxis and chronic treatment of asthma in adults and children older than age 12 NOT meant for management of acute asthmatic attacks Montelukast is approved for use in children ages 6 and older

83. Antileukotrienes: Side Effects zafirlukast Headache Nausea Diarrhea Liver dysfunction montelukast has fewer side effects

84. Antileukotrienes: Nursing Implications Ensure that the drug is being used for chronic management of asthma, not acute asthma Teach the client the purpose of the therapy Improvement should be seen in about 1 week

85. Corticosteroids Anti-inflammatory Used for chronic asthma Do not relieve symptoms of acute asthmatic attacks Oral or inhaled forms Inhaled forms reduce systemic effects May take several weeks before full effects are seen

86. Corticosteroids: Mechanism of Action Stabilize membranes of cells that release harmful bronchoconstricting substances These cells are leukocytes, or white blood cells Also increase responsiveness of bronchial smooth muscle to beta-adrenergic stimulation

87. Inhaled Corticosteroids Budesonide (Pulmicort�) Fluticasone (Flovent�)

88. Inhaled Corticosteroids: Indications Treatment of bronchospastic disorders that are not controlled by conventional bronchodilators NOT considered first-line agents for management of acute asthmatic attacks or status asthmaticus

89. Inhaled Corticosteroids: Side Effects Pharyngeal irritation Coughing Dry mouth Oral fungal infections Systemic effects are rare because of the low doses used for inhalation therapy

90. Inhaled Corticosteroids: Nursing Implications Contraindicated in client with psychosis, fungal infections, AIDS, TB Cautious use in clients with diabetes, glaucoma, osteoporosis, PUD, renal disease, HF, edema Teach clients to gargle and rinse the mouth with water afterward to prevent the development of oral fungal infections

91. Inhaled Corticosteroids: Nursing Implications (cont�d) Abruptly discontinuing these medications can lead to serious problems If discontinuing, should be weaned for 1 to 2 weeks, only if recommended by physician Report any weight gain of more than 2.5 kg a week or the occurrence of chest pain

92. PO corticosteroids Prednisolone (sold as Pediapred�) Prednisone (sold as Deltasone�)

93. Combination Medications Some pharmaceutical manufacturers have combined two controller medications into one inhaler. These inhalers are referred to as "Combination Medications".

94. Combination medications Combination � Corticosteroids Budesonide (Pumicort�) Formoterol (Oxeze�) Long-Acting bronchodilator Fluticasone (Flovent�) Salmeterol (Severent�)

95. Mast Cell Stabilizers Cromoglycate (sold as Intal�) Nedocromil (sold as Tilade�) Ketotifen fumarate (sold as Zaditen�)

96. Mast Cell Stabilizers: Indications Adjuncts to the overall management of asthma Used solely for prophylaxis, NOT for acute asthma attacks Used to prevent exercise-induced bronchospasm Used to prevent bronchospasm associated with exposure to known precipitating factors, such as cold, dry air or allergens

97. Mast Cell Stabilizers: Side Effects Coughing Sore throat Rhinitis Bronchospasm Taste changes Dizziness Headache

98. Mast Cell Stabilizers: Nursing Implications For prophylactic use only Contraindicated for acute exacerbations Not recommended for children younger than age 5 Therapeutic effects may not be seen for up to 4 weeks Teach clients to gargle and rinse the mouth with water afterward to minimize irritation to the throat and oral mucosa

99. Inhalers:Client Education For any inhaler prescribed, ensure that the client is able to self-administer the medication Provide demonstration and return demonstration Ensure the client knows the correct time intervals for inhalers Provide a spacer if the client has difficulty coordinating breathing with inhaler activation

100. Client Education Metered Dose Inhaler MDI Spacers Diskus Turbuhaler Nebulized

101. Inhalers fall into two categories Aerosol Inhalers: Pressurized metered dose inhaler is a canister filled with asthma medication suspended in a propellant. When the canister is pushed down, a measured dose of the medication is pushed out as you breathe it in. Pressurized metered dose inhalers are commonly called "puffers". Dry-powder inhalers: Dry powdered inhalers contain a dry powder medication that is drawn into your lungs when you breathe in.

102. Spacers should always be used with MDIs that deliver inhaled corticosteroids. Spacers can make it easier for medication to reach the lungs, and also mean less medication gets deposited in the mouth and throat, where it can lead to irritation and mild infections. The Asthma Society of Canada recommends that anyone, of any age, using a puffer, consider using a spacer.