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Analysis of Vitamin C and Calcium in Commercial Multivitamins

Analysis of Vitamin C and Calcium in Commercial Multivitamins. Andrew Mullenax Jesse Diehl Sam Yatzkan. Purpose. To determine the amount of Vitamin C and Calcium in a commercial multivitamin tablet through iodimetric and EDTA titration. Vitamin C Health Benefits.

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Analysis of Vitamin C and Calcium in Commercial Multivitamins

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  1. Analysis of Vitamin C and Calcium in Commercial Multivitamins Andrew Mullenax Jesse Diehl Sam Yatzkan

  2. Purpose • To determine the amount of Vitamin C and Calcium in a commercial multivitamin tablet through iodimetric and EDTA titration.

  3. Vitamin C Health Benefits • Helps tissue/bone grow and repair • Fights common cold (Despite minimal evidence) • Defend against scurvy • Helps the body absorb iron

  4. Calcium Health Benefits • Maintain bone health • Maintain heart rhythm • Control high levels Mg, P, K in blood • Recommended for post-menopausal women and persons who are lactose intolerant

  5. Procedure (Vitamin C) • Prepare stock solutions • Starch Indicator • Sodium Thiosulfate (Standardized) • Prepare samples • Crush/weight appropriate amount of tablet, titrate • Repeat for three good trials while adding starch indicator just before endpoint

  6. Procedure (Calcium) • Adjust Ammonia buffer to pH 10 • Prepare stock solutions • EDTA (Standardized) • Tablet Mixtures • Prepare samples with calmagite indicator • Titrate to violet endpoint with EDTA

  7. Calculations (Vitamin C) • KIO3 Solution: • Standardized Na2S2O3 Solution: • Trial 1: 0.074M • Ascorbic Acid needed for 15mL titration • Mol I3-

  8. Calculations (Vitamin C Cont’d) • Naturemade: • Trial 1: • Excess I3- • Mol I3-Present • Vitamin C present (g) • Wt% 0.005284g/1.3386g X100%=5.6%

  9. Calculations (Calcium) • CaCl2Molarity • Standardized EDTA • EDTA Molarity for NaturemadeSamples • Careone: Trial 1: • Wt%

  10. Calculations (Calcium Cont’d) • Naturemade: Trial 1: • Wt%

  11. Results (Vitamin C) • Naturemade (Advertised 180mg per tablet, [13.5%]) • Average: 5.1% • Careone (Advertised 60mg per tablet, [16.6%]) • Average: 10%

  12. Results (Calcium) • Naturemade (Advertised 162mg per tablet, [12.1%]) • Average: 14.1% • Careone (Advertised 45mg per tablet, [12.4%]) • Average: 19.2%

  13. Conclusions • Vitamin C • Average weight percent significantly lower than documented • Overshot endpoints • Calcium • Average weight percent was higher than documented • Difficult to see endpoint with calmagite indicator

  14. Possible Improvements • Use a better indicator for EDTA titration • Use less of crushed sample, more accurate prep. work (Vitamin C) • Perform more accurate titrations

  15. Resources • Http://naturemade.com/ • http://www.care1.info/BRANDS/VITAMIN/daily/daily.html • http://www.webmd.com/vitamins-and-supplements/lifestyle-guide-11/supplement-guide-vitamin-c • http://www.webmd.com/vitamins-and-supplements/lifestyle-guide-11/supplement-guide-calcium

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