Meiosis

1. Meiosis DO NOW : Many injuries to the skin heal completely, whereas injuries to the spinal cord, which is made mainly of nerve cells, may result in paralysis. Which characteristic of the two types of these body cells accounts for this difference?

2. Meiosis – A Source of Distinction Why do you share some but not all characters of each parent? What are the rules of this sharing game? At one level, the answers lie in meiosis.

3. Meiosis does two things - 1) Meiosis takes a cell with two copies of every chromosome (diploid) and makes cells with a single copy of every chromosome (haploid). This is a good idea if you’re going to combine two cells to make a new organism. This trick is accomplished by halving chromosome number. In meiosis, one diploid cells produces four haploid cells.

4. Why do we need meiosis? • Meiosis is necessary to halve the number of chromosomes going into the sex cells Why halve the chromosomes in gametes? • At fertilization the male and female sex cells will provide ½ of the chromosomes each – so the offspring has genes from both parents

5. 2) Meiosis scrambles the specific forms of each gene that each sex cell (egg or sperm) receives. This makes for a lot of genetic diversity. This trick is accomplished through independent assortment and crossing-over. Genetic diversity is important for the evolution of populations and species.

6. Meiosis Parent cell – chromosome pair Chromosomes copied 1st division - pairs split 2nd division – produces 4 gamete cells with ½ the original no. of chromosomes

7. Meiosis – mouse testes Parent cell 1st division 2nd division 4 gametes

8. Meiosis I : Separates Homologous Chromosomes • Interphase • Each of the chromosomes replicate • The result is two genetically identical sister chromatids which remain attached at their centromeres

9. Prophase I • This is a crucial phase for mitosis. • During this phase each pair of chromatids don’t move to the equator alone, they match up with their homologous pair and fasten together (synapsis) in a group of four called a tetrad. • Extremely IMPORTANT!!! It is during this phase that crossing over can occur. • Crossing Over is the exchange of segments during synapsis.

10. Metaphase I • The chromosomes line up at the equator attached by their centromeres to spindle fibers from centrioles. • Still in homologous pairs

11. Anaphase I • The spindle guides the movement of the chromosomes toward the poles • Sister chromatids remain attached • Move as a unit towards the same pole • The homologous chromosome moves toward the opposite pole • Contrasts mitosis – chromosomes appear as individuals instead of pairs (meiosis)

12. Telophase I • This is the end of the first meiotic cell division. • The cytoplasm divides, forming two new daughter cells. • Each of the newly formed cells has half the number of the parent cell’s chromosomes, but each chromosome is already replicated ready for the second meiotic cell division

13. Cytokinesis • Occurs simultaneously with telophase I • Forms 2 daughter cells • Plant cells – cell plate • Animal cells – cleavage furrows • NO FURTHER REPLICATION OF GENETIC MATERIAL PRIOR TO THE SECOND DIVISION OF MEIOSIS

14. Figure 13.7 The stages of meiotic cell division: Meiosis I

15. Meiosis II : Separates sister chromatids • Proceeds similar to mitosis • THERE IS NO INTERPHASE II !

16. Prophase II • Each of the daughter cells forms a spindle, and the double stranded chromosomes move toward the equator

17. Metaphase II • The chromosomes are positioned on the metaphase plate in a mitosis-like fashion

18. Anaphase II • The centromeres of sister chromatids finally separate • The sister chromatids of each pair move toward opposite poles • Now individual chromosomes

19. Telophase II and Cytokinesis • Nuclei form at opposite poles of the cell and cytokinesis occurs • After completion of cytokinesis there are four daughter cells • All are haploid (n)

20. Figure 13.7 The stages of meiotic cell division: Meiosis II

21. http://www.sumanasinc.com/webcontent/animations/content/meiosis.htmlhttp://www.sumanasinc.com/webcontent/animations/content/meiosis.html

22. One Way Meiosis Makes Lots of Different Sex Cells (Gametes) – Independent Assortment Independent assortment produces 2n distinct gametes, where n = the number of unique chromosomes. In humans, n = 23 and 223 = 6,000,0000. That’s a lot of diversity by this mechanism alone.

24. Another Way Meiosis Makes Lots of Different Sex Cells – Crossing-Over Crossing-over multiplies the already huge number of different gamete types produced by independent assortment.

25. Mitosis vs. Meiosis

26. The Key Difference Between Mitosis and Meiosis is the Way Chromosomes Uniquely Pair and Align in Meiosis Mitosis The first (and distinguishing) division of meiosis

27. Mitosis vs. Meiosis

28. Y chromosome X chromosome Boy or Girl? The Y Chromosome “Decides”

29. Boy or Girl? The Y Chromosome “Decides”

30. Meiosis – division error Chromosome pair

31. Meiosis error - fertilization Should the gamete with the chromosome pair be fertilized then the offspring will not be ‘normal’. In humans this often occurs with the 21st pair – producing a child with Downs Syndrome

32. 21 trisomy – Downs Syndrome Can you see the extra 21st chromosome? Is this person male or female?

33. Comparing Mitosis and Meiosis Do Now : Working with a partner • Describe the crossing over. What it is and when does it occur. • Explain Independent Assortment • Compare and contrast Mitosis and Meiosis ( T-chart)