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Hvor kritisk er innholdet av omega-3 hos oss mennesker?

Hvor kritisk er innholdet av omega-3 hos oss mennesker?. Livar Frøyland Forskningsdirektør NIFES 8. Maring FagDag 29. november 2012. Omega-3 from sea and land. Marine omega-3. Plant omega-3. Phytoplankton. Seafood. EPA and DHA . ALA ( alpha-linolenic acid ).

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Hvor kritisk er innholdet av omega-3 hos oss mennesker?

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  1. Hvor kritisk er innholdet av omega-3 hos oss mennesker? Livar Frøyland Forskningsdirektør NIFES 8. MaringFagDag 29. november 2012

  2. Omega-3 from sea and land Marine omega-3 Plant omega-3 Phytoplankton Seafood EPA and DHA ALA (alpha-linolenicacid) Documentedhealtheffects – cardiovasculardiseases Essential, throughdiet

  3. Dietaryintakeof plant omega-3 (ALA) versus marine omega-3 (EPA & DHA)? EPA & DHA ALA

  4. Omega-3 from sea and land Marine omega-3 Plant omega-3 Phytoplankton Seafood EPA and DHA ALA (alpha-linolenicacid) Lowconversion rate

  5. Background diet Dietaryintakeof marine omega-6 versus omega-3 (particularly EPA + DHA? EPA & DHA Omega-6

  6. Omega-3 from sea and land Marine omega-3 Plant omega-3 Phytoplankton Seafood EPA and DHA ALA (alpha-linolenicacid) Verylow, competitionwith omega-6

  7. Recommendations omega-3 fattyacids VKM (2011)

  8. Background diet EPA & DHA Omega-6

  9. 25.0lbs/pers/year-1999 1,000 fold increase 0.02 lbs/pers/year-1909 Hibbelen, personal communication

  10. X X X X = Actual tissue measures X Estimated tissue availability of n-6 eicosanoid precursors, (20:4n-6+20:3n-6, % PL-HUFA) Based on foods available for consumption in the U.S. 1909-1999 Hibbelen, personal communication

  11. Aspirin Other drugs >$ 10 Billion COX 1-2 COX 1-2 TXA3 PGE3 PGE2 TXA2 G PLA2 Gene Expression Thrombosis Japanese Diet U.S. Diet

  12. Cardiovascular deaths and Omega-3 in tissues 200 150 Cardiovascular mortality /100,000 100 50 0 15 55 65 85 25 45 75 35 % Omega-3 in tissue HUFA Hibbelen, personal communication

  13. Recommendations omega-3 (only EPA and DHA) for primarypreventionofcoronaryheartdiseases VKM (2011)

  14. Recommendations omega-3 (only EPA and DHA) for primarypreventionofcoronaryheartdiseases VKM (2011)

  15. Recommendations omega-3 (only EPA and DHA) for primarypreventionofcoronaryheartdiseases VKM (2011)

  16. Hjerne • Bortsett fra fettvev, er det hjernen som inneholder mest lipider (fett) i kroppen vår. • Hvis vi tørker hjernen, er 50-60 % vekten lipider • Av dette er 35% umettede fettsyrer, og de fleste er langkjedete slik som eikosapentaensyre (EPA) og dokosaheksaensyre (DHA) • DHA er særlig viktig for utvikling og vekst av hjerne

  17. Accumulation of DHA into the developing human brain

  18. Bildeav“økt RAM” Hibbeln, personal communication

  19. Demens (Alzheimer) >450 millioner lider av mentale, nevrologiske eller adferdsrelaterte lidelser på verdensbasis Depresjon Schizofreni Mental helse; hvordan er situasjonen i dag? 25% utvikler mentale lidelser eller adferdslidelser i løpet av livet. http://www.who.int/mental_health/en/

  20. Intake of seafood Highseafoodintake – less depression Post partum depression EPA & DHA? Norway Postpartum depression (EPDS) point prevalence (%) Hibbeln (2002) Journal of Affective Disorders, 69, 15-29

  21. Prevention (most people) versus treatment (patients) • Prevention, 0.25-0.5 g EPA+DHA/d • Treatment, 1-4 g EPA+DHA/d (medicine) • Health claims, 2-4 g EPA+DHA/d (”medicine”) • Whataboutprevention?

  22. Takk for oppmerksomheten

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