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Preconception and reproductive health for women and Men living with HIV

Preconception and reproductive health for women and Men living with HIV. Shannon Weber, MSW Judy Levison, MD, MPH Mary Jo Hoyt, MS, FNP. 2012 FTCC Meeting. What is preconception care it and why should we care about it?. Shannon Weber, MSW. Disclosures. We have no financial disclosures.

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Preconception and reproductive health for women and Men living with HIV

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  1. Preconception and reproductive health for women and Men living with HIV Shannon Weber, MSW Judy Levison, MD, MPH Mary Jo Hoyt, MS, FNP 2012 FTCC Meeting

  2. What is preconception care it and why should we care about it? Shannon Weber, MSW

  3. Disclosures • We have no financial disclosures.

  4. Goals of preconception care in the context of HIV infection • Prevent unintended pregnancy • Prevent HIV transmission to partner • Optimize maternal & paternal health • Improve maternal and fetal outcomes • Prevent perinatal HIV transmission • ACOGPractice Bulletin No 117; December, 2010

  5. Importance of preconception care • Women and men living with HIV want to have children. • Many pregnancies among HIV-infected women are unintended. • Contraception is under utilized, including men in the conversation. • Women and men face barriers related to stigma and conception with serodiscordant partners • Preconception counseling and care not addressed pro-actively • Reproductive health care often not a priority for patients or providers

  6. Estimated number of births to women living with HIV infection, 2000-2006 Office of Inspector General (Fleming), 2002 Whitmore, et al. CROI, 2009

  7. amfAR email survey of US adults, n=4831 (2008)

  8. HIV+ women internalize stigma around conception • Women Living Positive Survey • n=700 HIV+ women on ARVs for 3+ yrs • 59-61% believed could have children if appropriate care • 59% believed society strongly urges not to have children • Squires et al. AIDS PATIENT CARE and STDs 2011

  9. Reduce stigma, normalize desires

  10. What are reproductive rights? • The basic right of all couples and individuals to decide freely and responsibly the number, spacing and timing of their children and to have the information and means to do so, and the right to attain the highest standard of sexual and reproductive health. World Health Organization

  11. Hey, Mom………

  12. Unintended pregnancy Finer/Henshaw Perspec Sex Repro Health 2006; Massad AIDS 2004; Koenig AJOG 2007; Floridia Antivir Ther 2006

  13. Men’s sexual and reproductive health http://www.cicatelli.org/titlex/downloadable/MaleGuidelines2009.pdf • Provides guidance to programs that plan to develop or enhance clinical services for male clients • Defines the scope of male sexual and reproductive health services and set standards for their content and design • Provides a wide range of prevention, health education and treatment issues related to male health and sexual function

  14. HIV heterosexual serodiscordant couples • Estimated to be 140,000 US serodiscordant couples • About half desire children • Lampe, et al Am Journal Of Obst and Gyn, 204(6), 488e1-8, 2011 • Increasing call volume to the National Perinatal HIV Hotline (888-448-8765) from clinicians and patients seeking safer conception options.

  15. Every interaction is an opportunity • To discuss HIV status or testing • To discuss reproductive health desires • Preconception • Contraception • Safer conception The stories in our lives do not always coincide with the reminders in the medical health record. Start the conversation. Stay open. Repeat.

  16. Primary HIV care includes reproductive health • If we succeed at integrating preconception and family planning into primary care model • Every HIV-exposed pregnancy will be planned and well-timed • There will be no HIV transmission to infants or to uninfected partners • The health of all HIV-affected parents and infants will be optimized

  17. Preconception Care Case Studies Judy Levison, MD, MPH

  18. Rubella vaccination HIV/AIDS screening Management and control of: Diabetes Hypothyroidism PKU Obesity Folic acid supplements Avoiding teratogens: Smoking Alcohol Oral anticoagulants Accutane Science: There is evidence that individual components of preconception care work:

  19. Role Play!

  20. Case 1—Roberta • 30 year-old woman tested HIV+ positive during her recent pregnancy and started HIV treatment • CD4 (T-cells) have improved on treatment and her viral load is undetectable • Infant is 4 months old and HIV-uninfected • Plan: • Renew medications today, check labs before she returns for a check up in 3 months. • Encourage adherence • Remind to use condoms

  21. Case 1—Roberta… • You ask about contraception. • She previously used oral contraceptives and asks about restarting them. • How do you counsel her?

  22. Focus on couples where a partner is HIV-positive • How do you know if your patient and his/her partner are considering pregnancy? • You have to ask! • If they do NOT desire pregnancy, then ask what they are doing for contraception • Let’s review contraception and preconception counseling for couples who are infected or affected by HIV

  23. Condoms • The one method that protects against STDs and provides contraception • How do your clients feel about using male condoms? Female condoms?

  24. Male condoms

  25. Female condoms

  26. Condoms • However, 15% failure rate in preventing pregnancy • Many couples (even serodiscordant couples=one partner HIV+ and one partner HIV-) use condoms off and on, rather than always • So, a second method is recommended

  27. Oral contraceptives • Same criteria as for HIV- women if woman is NOT on antiretroviral therapy (ART) • Problematic for HIV+ women on ART • Ritonavir, lopinavir, nelfinavir, amprenavir, and darunavir (PIs) and nevirapine (NNRTI) increase metabolism of ethinyl estradiol and/or norethindrone, thus lowering efficacy of OCPs • Atazanavir (PI) and efavirenz (NNRTI) increase ethinyl estradiol levels (clinical impact unknown) ACOG (2010), Gynecologic care for women with human immunodeficiency virus. Practice Bulletin #117.

  28. Contraception

  29. Other hormonal options • Patch (Ortho Evra), vaginal ring (Nuva Ring), and transdermal implant (Implanon) • Warnings are similar to OCPs regarding drug-drug interactions • However, in theory, they avoid the “first pass” effect of liver metabolism that may occur with oral agents and should not be subject to the same limitations as OCPs • Depo-Provera: OK (concerns that DMPA might increase HIV viral shedding have not been supported) Conference on Retroviruses and Opportunistic Infections (March 2012), Seattle.

  30. Intrauterine devices (IUDs) • No known drug interactions • No increase in shedding of HIV • 2 types • Copper (Paragard) works for 10 years, may be associated with heavier menses, periods regular) • Levonorgestrel IUD (Mirena) works for 5 years, reduces menstrual blood loss (is FDA-approved as a treatment for menorrhagia), periods scant and not regular

  31. IUDs(2)

  32. Permanent sterilization • Laparoscopic tubal ligation • Essure (hysteroscopically placed coils in tubes) • Postpartum tubal ligation • Vasectomy

  33. Laparoscopic tubal ligation

  34. Essure

  35. Postpartum tubal ligation

  36. Vasectomy

  37. Integrating preconception and HIV care Challenges: • Lack of comfort and/or knowledge • Actual or perceived lower level of priority compared to other issues • Time constraints • Role of the primary care provider not entirely clear

  38. The Serodiscordant Couple

  39. Role Play!

  40. Case 2--Julia • Julia is 31, HIV+, diagnosed 2 years ago after ending a relationship with an HIV-infected partner • No history of HIV-related illness • Not on HIV medications • CD4 in the 600's • VL is 65, 000 • New partner is HIV-uninfected • Seems anxious and upset • Plan: • Discuss pros and cons of starting HIV treatment • Recommend HIV testing for partner • Reinforce the importance of using condoms. • Refer to a support group • Re-check her VL and CD4 in 3 months. • Continue to evaluate for and discuss HIV treatment

  41. Case 2—Julia … • You ask Julia if she wants to have another child. • She says, “Yes.” • You ask, “When?” • She says, “ Now.” • How do you counsel her?

  42. How do YOU feel about her wanting to get pregnant? • That is ridiculous—who will take care of your children if you die and you would risk having an HIV+ child? • I, as your health care provider, will be angry if you get pregnant. • I need to think about this. • You have every right to do this. Let’s work together to do it right.

  43. The first two responses may have been appropriate before we saw the successes of the HAART era • But in 2011: • Perinatal transmission is <1-2% • Men and women with HIV can expect to live to see their children grow into adulthood

  44. Preconception counseling • If a woman is not on ARVs, consider starting them prior to attempting conception • If a woman is on ARVs and is considering pregnancy • Substitute other ARVs for efavirenz (Sustiva) because of possible risk of neural tube defects (NTDs) • Recommend folate or prenatal vitamins preconceptionally to reduce chance of NTDs

  45. Serodiscordant couples • If the woman is HIV+ and the man is HIV-, discuss the options of: • Ovulation predictor kits • Home insemination (“turkey baster method”)

  46. Ovulation predictor kits These replace the old basal body temperature charts

  47. Whenthe time isright, thechoices are: • Home insemination with partner’s semen The “turkey baster” method *A needle-less syringe works fine

  48. Alternatives • Insemination in a doctor’s office with partner’s semen • Having penile/vaginal intercourse only during the 24 hours after the LH surge and using condoms the rest of the month—if this is the plan, then placing the woman on ARVs prior to attempted conception will further protect her partner • Post or pre-exposure prophylaxis for male? If yes, how many doses? Baeten, J. and Celum, C. 2011. Antiretroviral pre exposure prophylaxis for HIV prevention among heterosexual African men and women: The Partners PrEP Study. Int. AIDS Society, Rome.

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