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Bridging Lives The Process of Tissue Donation

Bridging Lives The Process of Tissue Donation. Seung Lee, BS, CTBS Tissue Hospital Services Specialist. Tissue Donation Circumstances. 55,659 total referrals in 2009 Brain Death – 5% Cardiac Death – 95% Tissue donation can occur in both Criteria differs than an organ donor.

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Bridging Lives The Process of Tissue Donation

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  1. Bridging Lives The Process of Tissue Donation Seung Lee, BS, CTBS Tissue Hospital Services Specialist

  2. Tissue Donation Circumstances • 55,659 total referrals in 2009 • Brain Death – 5% • Cardiac Death – 95% • Tissue donation can occur in both • Criteria differs than an organ donor

  3. Standards and Regulatory Agencies • U.S. Food and Drug Administration (FDA) – 1993 • Interim Rule • Good Tissue Practices • State of California (other states and countries) • Center for Medicare/Medicaid Services (CMS) • Calling in all deaths • Hospital Agreements with Tissue/Eye Bank

  4. Time Limitations • Tissues can become non-viable during the time the family considers the donation option • Refrigeration within 12 hours (15 vs. 24 hours) • Timely referrals allow the family the maximum time available to consult w/ one-another about the opportunity of donation • Domino Effect

  5. Tissue Distribution • Tissue is strictly monitored to maintain temperature requirements ranging from 10 degrees Celsius to -196 degrees Celsius • Graft Expiration: • Bone FZ = 5 years FD = 2-3 years • Skin FZ = 5 years Fresh = 14 days • CV FZ = 5 years • Corneas Refrigerated = 7 days

  6. Annual Cadaveric Tissue Transplants

  7. Autograft vs. Allograft

  8. Tissue Donation Potential ◄ Cornea/Eyes Heart Valves Skin Bone Tendons Cartilage Veins ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄ ◄

  9. The Gift of Sight A precious gift… A world of darkness …transplanted

  10. Skin • Increases burn survival from 17 to 77% • Promotes healing • Temporary coverage • Protects against: • fluid loss • Infection • Decreases pain

  11. Full Thickness Burn

  12. 2.5 years post-op(Courtesy Dr. Voorhees)

  13. Ruptured Omphalocele Courtesy Dr. Schrupp

  14. Placement of Acellular Dermis

  15. Wound Closure Day 129

  16. Tunneling Ulcer Post Debridement

  17. Particulate Acellular Dermis

  18. 6 Days

  19. Bone • Replacement for skeletal defects caused by cancer, trauma, or birth defects • Prevents amputation • 60% of allografts used in spinal surgeries • Allograft provides the matrix for recipient’s bone to grow and resume normal function

  20. Engineered Grafts

  21. Demineralized Bone with Carrier • Consists of bone matrix and a carrier such as glycerol, collagen, etc.

  22. Bone for Spinal Fusion Spinal curvature After bone grafts…

  23. Allograft & Host Junction

  24. Bone Matrix Injection

  25. Kacey Kacey in 2005 • Rode on the Donate Life Float in the 2005 Rose Bowl Parade • Fiancée proposed the night before parade. • Graduated from Nursing School • Got married • Became a spokesperson for Tissue Donation

  26. Kacey A Proximal Humerus was correctly matched by size and a medical director approved the graft for a limb-preserving surgical procedure on Kacey.

  27. Osteosarcoma Bone Graft into Defect Tumor excision Fixation of Matrix

  28. Connective Tissue • Tendons and Ligaments • Replace or strengthen damaged tissues in knees and other joints • Cartilage • Facial reconstruction • Fascia • Uterine & Bladder slings • Hernias

  29. Facial Suspension Reestablishment of facial symmetrywith a tissue sling Hemi-facial paralysis (Courtesy Dr. Frodel)

  30. Urological Surgeries Bladder Sling Procedures: Fascia is used to lift a bladder that doesn’t have the muscle control to keep in suspended.

  31. Vascular Grafts • Coronary bypass surgery • Restores blood flow • Prevents amputation

  32. Heart Valves/Pericardium • Replace defective heart valves • Better valve pressure than porcine or mechanical valves • No need for anti-coagulation drugs • Treatment of choice for pediatrics & women of childbearing age

  33. Gift of Movement

  34. Adam Teller, PTC

  35. A Future Without Limits

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