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Dasatinib ( nM ) 0 0 0.1 0.5 1 5

250K. 200K. Dasatinib (nM) 0 0 0.5 1 5 10 M-CSF - + + + + +. 88.6. WB: Phospho- FMS Y708 WB: FMS. 150K. 100K. 50K. 0. Dasatinib (nM) 0 0 0.5 1 5 10

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Dasatinib ( nM ) 0 0 0.1 0.5 1 5

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  1. 250K 200K Dasatinib (nM) 0 0 0.5 1 5 10 M-CSF - + + + + + 88.6 WB: Phospho- FMS Y708 WB: FMS 150K 100K 50K 0 Dasatinib (nM) 0 0 0.5 1 5 10 M-CSF - + + + + + B WB: Phospho- FMSY708 WB: FMS C D 200 Dasatinib (nM ) 0 0 0.1 0.5 1 5 M-CSF - + + + + + 160 Side scatter Cell event count 120 Wb: Phospho-Akt Akt 80 40 0 250K 200K 50K 100K 150K 0 0 102 103 104 105 Forward scatter CD14- FITC Figure S1 A Dasatinib (nM ) 0 0 0.1 0.5 1 5 M-CSF - + + + + + WB: Phospho-Erk WB: Erk WB: Phospho-Akt WB: Akt

  2. G H 120 120 100 E 100 80 80 % macrophage survival TAM per mm2 60 60 40 40 20 20 1 F 0 0.5 No M-CSF 0 0.5 1 Imatinib (μM) Imatinib (μM) J I

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