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Chapter 4: Carbohydrates. Plants Synthesize Glucose. Structure Glucose Fructose Galactose. Monosaccharides. Fructose (fruit sugar). Metabolized to glucose in the liver Found in fruit, honey, and high fructose corn syrup Is in sucrose. Galactose. Usually bound with glucose (lactose)
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Structure Glucose Fructose Galactose Monosaccharides
Fructose (fruit sugar) • Metabolized to glucose in the liver • Found in fruit, honey, and high fructose corn syrup • Is in sucrose
Galactose • Usually bound with glucose (lactose) • Converted to glucose in the liver • Available fuel source
Disaccharides • “Simple sugars” • Maltose (Gluc + Gluc) • Fermentation • Alcohol production • Sucrose (Gluc + Fruc) • Sugar • Lactose (Galactose + Gluc) • Milk products
Complex Carbohydrates • Polysaccharides: Starch & Glycogen • Amylose • Amylopectin • Dietary fiber
Oligosaccharides • 3-10 monosaccharides • Found in beans and legumes • Not digested • Metabolized by bacteria in the large intestine • Beno®
Polysaccharides: Starch • 3,000 or more monosaccharides bound together • Starch • Amylose--straight chain polymer • Amylopectin--highly branched polymer
Glycogen • Storage form of CHO for animals and human • Structure similar to amylopectin • More sites for enzyme action • Found in the liver and muscles
Dietary Fiber • Undigested plant food • Body cannot break the bonds • Insoluble fiber • Cellulos, hemicellulose, lignin • Not fermented by the bacteria in the colon • Soluble fiber • Gum, Pectin, Mucilage • Fruit, vegetable, rice bran, psyllium seed
Health Benefits of Dietary Fiber • Absorbs and holds water • Soften stool • Larger stool promotes peristalsis • Promotes regularity • Lower risk for cardiovascular disease • Decrease hemorrhoids and diverticula
Sweeteners • Sucrose--benchmark of all sweeteners • Same caloric content (4 kcals/gm) • No health benefit over another • Consumption ranges: 14-48 lbs/yr per person
Types of Sweeteners • High-fructose corn syrup • cornstarch treated with acid and enzymes • conversion of glucose into fructose • same degree of sweetness as sucrose • cheaper and used in many food products • Brown sugar • Maple syrup • Honey • Sugar alcohols • 1.5-3 kcal/g • Absorbed and metabolized slower • Large amount causes diarrhea
Sugar Substitutes • Saccharin • First produced in 1879 • 180-200x sweeter than sucrose • Excessive intake is linked to bladder cancer in lab animals • Not a potential risk in humans
Aspartame (NutraSweet) • Composed of phenylalanine, aspartic acid, and methanol • 180-200x sweeter than sucrose • 4 kcal/gm, but only a trace amount is needed to sweeten foods • Not heat stable • Complaints of sensitivity to aspartame • headaches, dizziness, seizures, nausea, etc. • Not recommended for people with phenylketonuria (PKU)
Acesulfame-K (Sunette) • Newest sugar substitute • 200x sweeter than sucrose • Not digested by the body • Heat stable • Diabetisweet used in baking
Sucralose (Splenda) • 600x sweeter than sucrose • Substitute chlorines for hydroxyl groups on sucrose • Heat stable • Tiny amount digested
Effects of Cooking • Softens fibrous tissues • Easier to chew and swallow
Digestion of Carbohydrate in the Mouth • Saliva contains amylase • Starch is broken down to shorter saccharides • Taste the sweetness with prolong chewing • Proceeds down the esophagus
Digestion of Carbohydrate in the Stomach • The acidic environment stops the action of salivary amylase • No further starch digestion occurs
In the Small Intestine • Pancreatic amylase is released • Intestinal cells release enzymes • Maltose + maltase glucose + glucose • Sucrose + sucrase glucose + fructose • Lactose + lactase glucose + galactose • Monosaccharides are absorbed
CHO Absorption • Glucose and Galactose • Active absorption • Energy is expended • Going from low to high concentration gradient • Fructose • Facilitated diffusion using a carrier • No energy expended
Portal Vein • Transport absorbed monosaccarhides • Delivers them to the liver • Liver can: • transform them into glucose • release them back into the blood stream • store as gylcogen (or fat)
Functions of Carbohydrate • Supplies energy • Protein sparing • Prevent ketosis • Sweetener
Regulation of Blood Glucose • Hyperglycemia • Hypoglycemia
Blood Glucose Control • Role of the liver • Regulates glucose that enters bloodstream • Role of the pancreas • Release of insulin • Release of glucagon
Functions of Insulin • Promotes glycogen synthesis • Increases glucose uptake by the cells • Reduces gluconeogenesis • Net effect: lowers the blood glucose
Functions of Glucagon • Breakdown glycogen • Enhances gluconeogenesis • Net effect: raises blood glucose
Epinephrine/ Norepinephrine • “fight or flight” response • breakdown glycogen • raises blood glucose
Diabetes Mellitus-Type 1 • Genetic link • Decreased release of insulin • Insulin dependent • Hyperglycemia • Immunological disorder • Early introduction of cow’s milk
Treatment for Type 1 • CHO counting • Insulin therapy • Risk for heart disease
Diabetes Mellitus-Type 2 • Genetic link • Associated with obesity • Non-insulin dependent to start • Accounts for majority of cases of DM • Defective insulin receptors on the cells • Over secretion of insulin to compensate • Leads to beta cells failure • Treatment: medication and diet therapy (weight loss)
Consequences of Uncontrolled Blood Glucose • Ketosis leading to ion imbalances, dehydration, coma, death • Degenerative diseases • Nerve damage, Heart disease, Kidney disease, Blindness • Atherosclerosis • Increase risk for wound infections
Hypoglycemia • Reactive hypoglycemia • Occurs 2-4 hours after eating a meal • Possibly due to over secretion of insulin • Fasting hypoglycemia • Usually caused by pancreatic cancer • Leads to overproduction of insulin
Sweetener Function • Enhances flavor • Use in moderation
Recommended Intake • No RDA (yet) • Consume at least 50 gm to prevent ketosis • National Cholesterol Education Program recommends 50-60% of kcal from CHO • Current intake is ~50%
Health Benefits of Dietary Fiber--Recall • Promotes softer, larger stool and regularity • Slows glucose absorption • Reduces blood cholesterol • Reduces heart disease • Reduces hemorrhoids and diverticula
Recommended Dietary Fiber Intake • 20-35 gm of fiber/day (10-13 gm/1000 kcals) • Children: age +5gm/day • Ave. U.S. intake: ~16 gm/day • Too much fiber (>60 gm/d) will: • require extra intake of fluid • bind to some minerals • develop phytobezoars • fills the stomach of a young child quickly
Recommendation for Simple Sugar Intake • Low nutrient density • Recommends no more than 10% of total kcal/day • Ave. U.S. intake: 16% of total kcal/day • Added to food and beverages during processing
High Sugar Diets • Empty calories • Soda replacing milk • Calories adding to excess • Dental caries • exposure to teeth • High glycemic index • Blood glucose response of a given food • Influence by various factors
Effects of High Glycemic Index CHO • Stimulates the release of insulin • Insulin’s effect blood triglycerides level • Insulin’s effect LDL • Insulin increases fat synthesis • Return to hunger quicker • Develop insulin resistance
Lactose Intolerance • Reduction in lactase • Lactose is undigested and not absorbed • Lactose is metabolized by large intestinal bacteria • causes gas, bloating, cramping, discomfort • Primary lactose intolerance disease • Secondary lactose intolerance disease
What To Do If You Are Lactose Intolerance • Determine amount you can tolerate • Eat dairy with fat • Cheese & yogurt are usually tolerated well • Use of Lact-Aide