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Michael Baram Medical Critical Care. Relationship Between SIRS, Sepsis and Severe Sepsis. Other. Sepsis. Severe Sepsis. Pancreatitis. Infection. SIRS. Trauma. Burns. Bone RC, et al. Chest 1992;101:1644-55. Vincent JL. Crit Care Med 1997;25:372-4. Wall street journal.
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Relationship Between SIRS,Sepsis and Severe Sepsis Other Sepsis Severe Sepsis Pancreatitis Infection SIRS Trauma Burns Bone RC, et al. Chest 1992;101:1644-55. Vincent JL. Crit Care Med 1997;25:372-4.
Surviving SepsisBundles • Sepsis Resusciation Bundle • Management Bundle • . • . • VentilatorBundle • .
Surviving SepsisBundles • VentilatorBundle • Head of bed . • Oral Care . • Sedation Holiday . • Peptic Ulcer . • DVT Proph . • Sepsis Resusciation Bundle • Lactate . • Early Cultures . • Appropriate Abx . • Source Control . • Volume Expansion Cvp 8-12 . • PressorsMAP >65 . • Inotropes SCVO2 > 70 . (t/c blood) . • Management Bundle • Glycemic Control . • Activated Protein C . • Stress Steroids . • Limit Blood Products . • Limit Vent Stretch . • Limit Bicarb . pH<7.15 .
Surviving SepsisBundles • VentilatorBundle • Head of bed • Oral Care • Sedation Holiday • Peptic Ulcer • DVT Proph. • Sepsis Resusciation Bundle • Lactate . • Early Cultures • Appropriate Abx • Source Control • Volume Expansion Cvp 8-12 • PressorsMAP >65 • Inotropes SCVO2 > 70 (t/c blood) • Management Bundle • Glycemic Control. • Activated Protein C • Stress Steroids. • Limit Blood Products • Limit Vent Stretch • Limit Bicarb pH<7.15
Lactate- Predictor of Mortality • Ann Emergency Med. 2005;45:524-528 • 1200 consecutive patients presenting with sepsis • Ann Emergency Med. 2005;45:524-528 • 1200 consecutive patients presenting with sepsis
Early Appropriate ABX Kumar et al, Critical Care 2006 Jun 34 (6) 1589-96
Wrong Vent Setting normal lung 5 minutes (peak press 45) 20 min (peak 45) Dreyfuss Am. J. Respir. Crit. Care Med., Volume 157, Number 1, January 1998, 294-323