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The Residual Group Project #1 of 3

The Residual Group Project #1 of 3. Neuropathological Associates of Multiple Cognitive Functions in Two Community-Based Cohorts of Older Adults. Members of the Residual Group Maritza Dowling Dan Mungas Sarah Tomaszewski-Farias Bruce Reed Milton Strauss. Aim.

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The Residual Group Project #1 of 3

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  1. The Residual Group Project #1 of 3 Neuropathological Associates of Multiple Cognitive Functions in Two Community-Based Cohorts of Older Adults Members of the Residual Group Maritza Dowling Dan Mungas Sarah Tomaszewski-Farias Bruce Reed Milton Strauss

  2. Aim • To use data from MAP & ROS cohorts to examine the relationships between cognitive domains and indices of neuropathology commonly associated with aging and cognitive decline. • N=652

  3. Main Steps Identify the underlying factor structure of • the battery of neuropsychological tests used in MAP & ROS (17 tests), and • observed measures associated with neuropathological changes characteristic of Alzheimer’s disease, cerebrovascular disease, and LBD

  4. Main Steps (Cont.) • Apply a Multiple Indicators Multiple Causes (MIMIC) approach to investigate the effect of particular neuropathological substrates on the identified cognitive domains

  5. Latent Structure of the Neuropathology Variables

  6. Neurofibrillary Tangle Counts for Mid-Frontal Brain RMSEA=0.074 90 Percent C.I. (0.066, 0.082) CFI=0.943, TLI=0.929 SRMR=0.046 Chi-sq Value=356.452* Degrees of Freedom=84 p-value=0.0000 0.778 Neuropathological Factor 1 (NFT1) Neurofibrillary Tangle Counts for Inferior-Parietal Region 0.839 Neurofibrillary Tangle Counts for Mid-Temporal Region 0.896 0.603 Neurofibrillary Tangle Counts for Entorhinal Cortex Region 0.869 Neuropathological Factor 2 (NFT2) Neurofibrillary Tangle Counts for CA1 Hippocampal Region 0.818 0.696 Neuritic Plaque Counts for Mid-Frontal Brain Region 0.863 0.577 Neuritic Plaque Counts for Mid-Temporal Region 0.912 0.494 Neuropathological Factor 3 (NP) Neuritic Plaque Counts for Inferior-Parietal Region 0.850 0.824 Neuritic Plaque Counts for Entorhinal Cortex Region 0.434 0.762 Neuritic Plaque Counts for CA1 Hippocampal Region 0.745 Diffuse Plaque Counts for Mid-Frontal Brain Region 0.909 0.874 Neuropathological Factor 4 (DP) Diffuse Plaque Counts for Mid-Temporal Region 0.896 Diffuse Plaque Counts for Inferior-Parietal Region 0.571 4-Factor CFA Solution Using Combined ROS & MAP Data (N=652) ***Adding Diffuse Plaque Counts Diffuse Plaque Counts for CA1 Hippocampal Region 0.659 Diffuse Plaque Counts for Entorhinal Cortex Region Vars re-coded 0-9; treated as continuous

  7. R-SQUARE Observed Two-Tailed Variable Estimate S.E. Est./S.E. P-Value MFRNPCT 0.744 0.027 27.920 0.000 MTMNPCT 0.832 0.019 43.310 0.000 IPNPCT 0.722 0.028 25.569 0.000 ENTNPCT 0.680 0.028 24.444 0.000 HIPNPCT 0.580 0.032 18.063 0.000 MFRDPCT 0.826 0.021 38.624 0.000 MTMDPCT 0.763 0.025 30.105 0.000 IPDPCT 0.803 0.023 35.283 0.000 ENTDPCT 0.434 0.036 12.062 0.000 HIPDPCT 0.326 0.039 8.477 0.000 MFRNFTCT 0.605 0.049 12.343 0.000 MTMNFTCT 0.802 0.036 22.180 0.000 IPNFTCT 0.705 0.042 16.856 0.000 ENTNFTCT 0.755 0.049 15.270 0.000 HIPNFTCT 0.670 0.049 13.574 0.000

  8. Latent Structure of the Neurocognitive Scales

  9. Modeling the Underlying Structure of the Neuropsychological test Battery-Model # 1 17 scales Six Factors story scdf delay scdb scwli epis scdoperf wrkmem scwlii scsdmt scebmt scnccrtd persp scebdr sclopair scbname scpmat perorg sem scread fluency animals fruits CFI=0.96; TLI=0.946; RMSEA=0.068 with 90% CI=(0.060-0.075); SRMR=0.034 Chi-square=373.68; df=101; p=0.00 0.842 0.903 0.819 0.827 0.841 0.894 0.773 0.793 0.855 0.801 Range of correlations between factors:0.773-0.903

  10. R-SQUARE Observed Two-Tailed Variable Estimate S.E. Est./S.E. P-Value STORY 0.740 0.023 31.604 0.000 DELAY 0.711 0.026 27.222 0.000 SCWLI 0.787 0.022 35.409 0.000 SCWLII 0.669 0.035 19.309 0.000 SCEBMT 0.703 0.029 24.021 0.000 SCEBDR 0.673 0.027 24.665 0.000 SCBNAME 0.824 0.036 23.125 0.000 SCREAD 0.474 0.050 9.444 0.000 ANIMALS 0.816 0.020 40.728 0.000 FRUITS 0.834 0.020 40.829 0.000 SCDF 0.544 0.041 13.361 0.000 SCDB 0.704 0.026 27.238 0.000 SCDOPERF 0.761 0.033 23.120 0.000 SCSDMT 0.922 0.020 46.174 0.000 SCNCCRTD 0.715 0.027 26.653 0.000 SCLOPAIR 0.514 0.046 11.280 0.000 SCPMAT 0.668 0.048 13.981 0.000

  11. MIMIC MODEL WITH THE 6-FACTOR COGNITIVE STRUCTURE & THE 4-FACTOR NEUROPATH MODEL ASSUMING THE ROLE OF COVARIATES Two models: WITHOUT/WITHBRAIN WEIGHT (adjusted for height & gender), MICROINFARCTS, STROKES, & LEWY BODIES ALSO AS COVARIATES

  12. A Multiple Indicator Multiple Independent Cause (MIMIC) Model for the Relationship Between Neuropathology and Cognition-WITH Brain Weight

  13. Results

  14. Continues

  15. Next Steps Finish paper for Project #1 We have a draft of the paper. We need to work on discussion--Implications & Conclusion

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