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Organophosphate poisoning

Organophosphate poisoning. 1030717. Pralidoxime. I.V.:

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Organophosphate poisoning

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  1. Organophosphate poisoning 1030717

  2. Pralidoxime • I.V.: • Loading dose: 1000-2000 mg; Maintenance: Repeat bolus of 1000-2000 mg after 1 hour and repeated every 10-12 hours thereafter, as needed. Alternatively, administer a loading dose of 30 mg/kg followed by a maintenance infusion of 8 mg/kg/hour (unlabeled dose; Roberts, 2007). • I.M.: • Mild symptoms: 600 mg; repeat as needed for persistent mild symptoms every 15 minutes to a maximum total dose of 1800 mg; may administer doses in rapid succession if severe symptoms develop • Severe symptoms: 600 mg; repeat twice in rapid succession to deliver a total dose of 1800 mg • Pralidoxime chloride inj. 500mg

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