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BIO CLOCK

BIO CLOCK. B. E. S. T (97`). AN BUM JU. DEFINITION. 일정한 주위상황( Constant Condition) 에서 반복적으로 일어나는 행동이나 생리학적 변화의 주기. CLASSIFICATION. Ultradian rhythm 심장박동,체온의 변화, 호흡, 눈깜빡임 Circadian rhythm 밤/낮의 변화 Infradian rhythm 여성의 생리, Life Cycle. HISTORY. Bio-clock 의 발견

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BIO CLOCK

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  1. BIOCLOCK B. E. S. T (97`) AN BUM JU

  2. DEFINITION • 일정한 주위상황(Constant Condition)에서 반복적으로 일어나는 행동이나 생리학적 변화의 주기

  3. CLASSIFICATION • Ultradian rhythm • 심장박동,체온의 변화, 호흡, 눈깜빡임 • Circadian rhythm • 밤/낮의 변화 • Infradian rhythm • 여성의 생리, Life Cycle

  4. HISTORY • Bio-clock의 발견 • 개화의 주기성 최초 기록(Androsthenes,4세기) • Bio-clock의 존재 증명(Gustav Kramer, Klaus Hoffman, 1950) • 분자 수준의 재발견 • Per gene cloning(Bargiello et al,1984) • Clock gene cloning(Lowery et al,1997)

  5. Hormonal pathway Neural pathway DIAGRAM 자극 SCN Pineal gland Hormone ex) melatonin Target Cell

  6. (Suprachiasmatic nucleus)SCN • 8000~10000개의 neuron으로 구성. • 좌우 양쪽에 있음 • 눈에서 오는 자극 수용 • Time signal의 생성

  7. (PACEMAKER? )SCN • SCN제거(Moore and Eichler, 1972) Bio-clock을 잃어버림. • SCN transplantation(Lehman and Ralph, 1990) Donor SCN Transplantation Recipient SCN recipient는 donor의 Bio-clock를 따른다.

  8. 자극 SCN Pineal gland Hormone Target Cell 최근 연구 동향 • Reset/entrainment • Internal bio-clock

  9. INTERNAL • Positive feedback system (+) • Negative feedback system (-) • (+) and (-) of Harmony

  10. RESET/ENTRAINMENT • PER/TIM heterodimer • TIM protein 분해 (by light)

  11. (AGING?) BIO-CLOCK • Bio-clock으로 aging hormone조절 가능성( Science, 1997) • Transplantation (J Biol Rhythms, 1998) Young SCN Transplantation Older SCN 20%수명연장 (노화억제 가능성시사)

  12. DISEASE • SAD(seasonal affective disorder) • FASPS(familial advanced sleep-phase syndrome) • SMS(Smith-magenis syndrome) 계절에 따른 감정의 변화

  13. FASPS • Per2 genemutation • CK1e binding site • Amino acid Change (from Serine to Glysine on 446th amino acid)

  14. SMS • Chromosome deletion or duplication (17th P11.2 region)

  15. THERAPHY • Chronotheraphy • Cancer theraphy • Sleeping disorder • Shift workers • Neuropsychiatric illness • Jet lag

  16. ZET LAG • Difference of reset-ability gap (between SCN and peripheral –oscillation.)

  17. Hormonal pathway Neural pathway MORE STUDY • Developmental timer (clock in embryo ) • Food • Temperature • Peripheral oscillator mechanism • SCN coupling to Peripheral oscillator • SCN gene function • Infradian rhythm (how to accumulate rhythm) • Relation between bio-clock and aging • Other reset/entrainment

  18. CONCLUSION • Bio-clock에 대해 아직 알려지지 않은 부분이 많다. • Human genome project 이후 bio-clock에 대한 연구는 가속화 될 것이다. • Bio-clock와 다른 연구 분야의 상호 연구가 이루어져야 한다.

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