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The Pyrrole - reactivity

The Pyrrole - reactivity. Jan Lewtak. Pyrrole - numbering. Plan of the lecture. Review of the reactions with pyrrole. Electrophilic attack at carbon Condensation Oxidising Reducing Cycloaddition Toxicity. Protonation. Stability :. Most stable medium least stable. No mesomeric

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The Pyrrole - reactivity

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  1. The Pyrrole - reactivity Jan Lewtak

  2. Pyrrole - numbering

  3. Plan of the lecture. Review of the reactions with pyrrole • Electrophilic attack at carbon • Condensation • Oxidising • Reducing • Cycloaddition • Toxicity

  4. Protonation Stability: Most stable medium least stable No mesomeric stabilisation

  5. Nitration & Sulfonation

  6. Halogenation

  7. Bromination

  8. Acylation

  9. Acylation

  10. Alkylation

  11. Condensation coloured

  12. Condensation of pyrrole with itself

  13. Oxidising of C-substituents

  14. Oxidation of the heterocyclic ring

  15. Reactions of C-metallated pyrroles

  16. Reactions of C-metallated pyrroles

  17. Reducing in acidic conditions

  18. Decarboxylation, bromination and formylation of carboxylic derivatives

  19. Cycloaddition

  20. And now… important type of reactivity in laboratory work. „In vivo” reactivity.

  21. Produkt toksyczny przy wdychaniu. Działa szkodliwie przez drogi oddechowe. Ryzyko poważnego uszkodzenia oczu. W przypadku wysłuchania wykładu nt. pirolu natychmiast skontaktować się z Ośrodkiem Zatruć i zapewnić warunki do odpoczynku w pozycji umożliwiającej swobodne oddychanie.

  22. Thank You for Your Attention

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