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Supplementary Figure 3

HCT116. HCT116-TP53KO. NT. 5FU. Ox. NT. 5FU. Ox. 5. 2. 4. LC3. 3. IC50 5FU (µM). 1. IC50 Oxaliplatin (µM). 2. 1. GAPDH. 0. 0. HCT116. HCT116 TP53KO. HCT116. HCT116 TP53KO. 6. 5. 4. 7. HCT116. IC50 5FU (µM). 3. 6. HCT116. 0.4. 2. 5. 4. 1. 0.3. IC50 5FU (µM).

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Supplementary Figure 3

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  1. HCT116 HCT116-TP53KO NT 5FU Ox NT 5FU Ox 5 2 4 LC3 3 IC50 5FU (µM) 1 IC50 Oxaliplatin (µM) 2 1 GAPDH 0 0 HCT116 HCT116 TP53KO HCT116 HCT116 TP53KO 6 5 4 7 HCT116 IC50 5FU (µM) 3 6 HCT116 0.4 2 5 4 1 0.3 IC50 5FU (µM) 3 IC50 Oxaliplatin (µM) 0 0.2 1.6 siLUC siATG5 si ATG7 2 1.4 1 0.1 1.2 0 1 0 siLUC siATG5 si ATG7 IC50 Oxaliplatin (µM) 0.8 siLUC si ATG5 si ATG7 0.6 0.4 0.2 0 siLUC si ATG5 si ATG7 HCT116-TP53KO HCT116-TP53KO Supplementary Figure 3 A B D C E F

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