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Introduction

Growth Hormone and Aging: Assessment of Growth Parameters and Life Span of GHR/BP Gene-disrupted Mice By Hasan Zaidi. Introduction. Search for the “Fountain of Youth” Therapeutic Approach of GH As an Anti-aging Agent Can Be Dangerous

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Introduction

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  1. Growth Hormone and Aging:Assessment of Growth Parameters and Life Span of GHR/BP Gene-disrupted MiceBy Hasan Zaidi

  2. Introduction Search for the “Fountain of Youth” Therapeutic Approach of GH As an Anti-aging Agent Can Be Dangerous What Role Does GH Play in the Control of Other Growth Factors?

  3. Background Growth hormone secretion from the pituitary is highest around puberty GH secretion declines with age due to decreased secretion of GHRH from hypothalamus and increased secretion of somatostatin, the GH-inhibiting hormone

  4. Rationale Authors wanted to study the effects of loss of GH signaling on growth and aging Used a mouse model for Laron Syndrome in which the GHR/BP gene has been disrupted

  5. 3 Types of Mice Used: Nontransgenic (+/+)Heterozygous (+/-)Homozygous (-/-)

  6. ResultsGHR/BP -/- Mice Grow More Slowly and Remain Significantly Smaller Than Their +/+ and +/- Littermates

  7. ResultsGHR/BP -/- Mice Grow More Slowly and Remain Significantly Smaller Than Their +/+ and +/- Littermates

  8. ResultsIGF-I Levels Remain Significantly Lower in GHR/BP -/- Than in +/+ and +/- Mice

  9. ResultsIGFBP-3 levels are severely reduced in GHR/BP -/- mice

  10. Gender Genotype N Scanning units1 Males +/+ 7 5512 +/- 164 -/- 7 210 +/- 722 Females +/+ 7 6125 +/- 492 -/- 6 310 +/- 442 ResultsIGFBP-3 levels are severely reduced in GHR/BP -/- mice Table 1. Scanning densitometry values for IGFBP-3 1 Mean ± SE. 2P < 0.001 compared with +/+.

  11. Gender Genotype N Lifespan (days)1 Males +/+ 7 629 +/- 72 +/- 8 668 +/- 51 -/- 7 975 +/- 1062 Females +/+ 13 749 +/- 41 +/- 19 701 +/- 36 -/- 11 1031 +/- 413 ResultsGHR/BP -/- Mice Live Longer Than Their +/+ and +/- Littermates Table 2. Analysis of lifespan in GHR/BP gene-disrupted mice 1 Mean ± SE. 2P < 0.01 compared with +/+. 3P < 0.0002 compared with +/+.

  12. Now What? Normal or High Levels of GH May Accelerate Aging, As Shown in the +/+ and +/- Mice Results From the Study Contradict the Anti-aging GH Data and Suggest the Need for Further Analysis of GH and Its Relationship to Aging

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