Pharmanex

1. Pharmanex Product Training

2. Cortitrol:Dietary Supplement Cortitrol is a supplement that assists you in dealing with difficult situations. Take Control!

3. What is Cortitrol? Introducing Cortitrol Cortitrol is a unique dietary supplement that addresses the symptoms of a fast-paced lifestyle. Cortitrol’s ingredients balance the level of cortisol in the body.

4. What is Cortisol? Background Cortisol is a hormone produced by your body in response to difficult events. The occasional release of cortisol is essential to respond to emergency situations. Too frequent release of cortisol can lead to health problems.

5. What is Cortisol? Cortisol The role of Cortisol in Health and Longevity.

6. What is Cortisol? Today’s Health Demons • 1980’s = Cholesterol • Early 1990’s = Free Radicals / Antioxidants • Later 1990’s = Insulin / Blood Sugar • 2000’s = Cortisol

7. What is Cortisol? Cortisol in the Media • More Than 1,000 News Articles Over the Past Year! • Time, Washington Post, Reader’s Digest, etc • 1st International Symposium on Cortisol, Stress and Health • May 2002 • New Book: The Cortisol Connection...Why Stress Makes You Fat & Ruins Your Health…And What You Can Do About It • Published September 2002

8. What is Cortisol? • The body’s primary stress hormone: • “Fight-or-Flight” response • Required by the body for survival • Regulates inflammation, carbohydrate metabolism, cardiovascular function, etc… • BUT too much of cortisol for too long leads to problems: • Repeated exposure to stressful situations (personal, family, work) • Modern stressors do not permit “fight-or-flight” • Stress hormones do not dissipate • Stress can lead to degenerative health consequences

9. STRESS What is Cortisol? • ACUTE STRESS • brief • normal circadian rhythm • adaptive • CHRONIC STRESS • prolonged & repeated • disrupted circadian rhythm • maladaptive

10. What is Cortisol? Repeated Stress Elevates Cortisol

11. What is Cortisol? The Relationship Between Elevated Cortisol and Stress Related Conditions Scientific Evidence

12. What is Cortisol? Impact of Elevated Cortisol in: • Obesity & Metabolic Syndrome • High cortisol secretion = abdominal fat = illness • Suppressed Immunity • Associated with low counts of white blood cells • Acute psycholsocial and sleep deprivation stress disrupts skin barrier homeostasis • Changes due in part from increased cortisol levels.

13. What is Cortisol? Impact of Elevated Cortisol in: • Appetite • People who diet have high cortisol secretion • Bone Metabolism • High cortisol secretion = dietary restraint = implications for bone health

14. What is Cortisol? Other Research Additional research has also identified many other health issues associated with elevated cortisol levels.

15. Stress and Health Care Costs Work Demands Increased Health Care Costs $$$ Cortisol Reactivity Job Control Ganster et al. Journal of Applied Psychology, 2001, 86, 954-964.

16. What is Cortisol? Cortisol Levels are Elevated in… • Chronic Stress • Sleep Deprivation • Dieting / Restrained Eating Adults who need to control cortisol levels: • Get less than 8 hours sleep • Feel run-down, lack of mental focus • Limit caloric intake to lose weight • Often in difficult situations

17. The Market: Prevalence of Chronic Stress • 80% of workers report feeling stress on the job • Stress contributes to half of all illnesses in the US • 70-80% of all doctor visits are stress-related • >50% all deaths between the ages of 1 and 65 result from stress Sources: U.S. Center for Disease Control; World Health Organization; www.whmc.af.mil; 2000 Gallup Poll “Attitudes in the American Workplace”

18. The Market: Prevalence of Chronic Stress • Generalised anxiety disorder affects an estimated 183 million people worldwide • People who live in a high state of anxiety are 4.5 times more likely to die prematurely Sources: U.S. Center for Disease Control; World Health Organization; www.whmc.af.mil; 2000 Gallup Poll “Attitudes in the American Workplace”

19. The Solution: Cortisol Management • You can control cortisol levels via: • Stress Management Techniques • Meditation, coping strategies, etc… • Exercise • Optimal Nutrition • LifePak and Tegreen 97 • Dietary Supplements • Cortitrol, LifePak and Tegreen 97

20. Common Anti-Stress Solutions • Valerian • Kava Kava • Melatonin • Tyrosine None of these supplements directly address cortisol control

21. What is Cortitrol? Cortitrol • Enhances feelings of well-being and control in response to difficult situations • Improves performance and increased vigour throughout the day • Generates better mental concentration and focus • Supports weight maintenance efforts

22. Cortitrol: Advantage • Unique patent-pending dietary supplement that supports healthy cortisol levels • Proprietary (company owned) blend & comprehensive ingredients • Balances cortisol levels • Contains a proprietary, all-natural form of theanine extract • Manufactured according to the highest TGA standards and the Pharmanex 6S Quality Process

23. Cortitrol: Proprietary Formula • Comprehensive, proprietary formula that addresses direct cortisol modulation • Scientifically validated ingredients in clinically significant dosages • Magnolia Bark • Phosphatidylserine • Epimedium • L-Theanine

24. Cortitrol: Product Positioning Tegreen 97 Antioxidant Protection Joint Formula Joint Health BioGinkgo 27/7 Memory & Concentration LifePak Jungamals LifePak for Kids General Health & Well-Being Optimum Omega Heart Health FibreNet Plus Digestive Health Cortitrol OverDrive Sports Nutrition FibreNet Digestive Health Weight Management CordyMax Cs-4 Vitality & Stamina Fatigue

25. OPTIMAL HEALTH Inner Health Memory FibreNet BioGinkgo 27/7 Protection Optimum Omega Joint Formula LifePak/ Cortitrol Tegreen 97 OPTIMAL HEALTH FOUNDATION BLOCKS Jungamals LifePak for Kids

26. Cortitrol: Recommended Usage • Take two (2) tablets with your evening meal. For optimal results take an additional one (1) tablet with your morning meal

27. Cortitrol: And LifePak • Promote Cortitrol to be taken with LifePak. • Why? • Optimal nutritional health which includes vitamin C, B1, B2, Calcium, Magnesium, Pantothenic acid, and Pyridoxine, combined with cortisol modulation.

28. Cortitrol: Ingredients • Magnolia Bark • Phosphatidylserine • Epimedium • Theanine

29. Cortitrol: Product Support • Clinical Studies & references on individual ingredients in the formula • Pharmanex Web Site – www.pharmanex.com.au or www.pharmanex.co.nz • PubMed Web Site - www.ncbi.nlm.nih.gov/entrez/query.fcgi • Also on our web site: • Product Information • Q&As • Training Material • General Health Facts

30. Cortitrol: Q&A • Why does Cortitrol come in tablet form? • Better cost value • Is there a difference b/w Epimedium brevicornum and koreanum? • No. Both are from two similar plants but have the same efficacy, the same active component. TGA preferred we use brevicornum.

31. Cortitrol: Q&A • Are there any known drug interactions? • If you are pregnant or lactating, have a known medical condition or are taking a prescription medication, or are allergic to any component of this product, consult a physician prior to use. • Will coffee or caffeine negate the effectiveness of Cortitrol? • No, coffee or caffeine will not "negate" the effects of Cortitrol; rather, Cortitrol would be expected to permit the "energy" benefits of coffee but without the "jittery" side effects.

32. Cortitrol: Q&A • There are several hormones regarding stress besides cortisol. Why is Pharmanex focusing on cortisol and not the others? • Cortisol is the primary stress hormone. When we experience stress, cortisol is the stress hormone that remains elevated the longest. • Will Cortitrol make it hard for me to sleep at night? • In some cases, Cortitrol users have experienced increases in energy levels and makes them feel more alert. We suggest taking Cortitrol in the morning, rather than the evening, which seems to help.

33. Cortitrol: Q&A • What is the normal range of cortisol levels? • The "normal" range for blood cortisol levels is fairly wide, 6-23 mcg/dl, but these levels can vary tremendously in response to stress, illness, and even following meals.

34. Cortitrol: Q&A • Any drug or medical interactions? • We have found that people are able to take Cortitrol with most medications. Just like all of our products, however, we do not know all the potential interactions with Cortitrol. As always, we must recommend that they discuss this product with their doctor or pharmacist who knows their prescription history. • If you are pregnant or lactating, or taking a prescription medication, have a known medical condition, or allergic to any component of this product, please consult a physician prior to use. Consult a physician if you are taking prescription "anti-stress" medications such as anxiolytics, sedatives, or hypnotics. Consult a physician if you are taking other CNS depressants, tricyclic antidepressants, anti-epileptics, muscle relaxants, anticoagulants, corticosteroids and quinalone antibiotics. Use of l-theanine concomitantly with chemotherapeutic agents must be done under medical supervision. L-theanine may enhance the effects of doxorubicin, idarubicin, adriamycin, and picarubicin and may ameliorate some of their side effects (PDR for Nutritional Supplements 2001, Sadzuka 1996, Sugiyma 1998, 1999). This supplement should be discontinued two weeks prior to surgery.

35. Cortitrol: Marketing Material • Pharmanex Brochure (5 pk) $8.00 • Pharmanex Cap (ea) $12.95 • Power of Wisdom & Knowledge Video (ea) $7.50 • Pharmanex Pill Box (ea) $3.00 • Cortitrol Brochure (5 pk) $4.50 • The Cortisol Story Brochure (5 pk) $9.50 • Stress Test Card (5 pk) $11.00

36. Cortitrol • Summary • Balances cortisol levels • Proprietary blend of ingredients shown to have direct effects on cortisol levels • Proprietary l-theanine ingredient • Today’s answer to the fastest growing health demon!

37. Cortitrol • Next Steps • Order Today! • Spread the word • Ensure all Distributors and Customers benefit from purchasing through ADP.