Heparin-Induced Thrombocytopenia

Heparin-Induced Thrombocytopenia. Lawrence Rice, MD Chief, Division of Hematology Clinical Chief, Hem/Onc Service The Methodist Hospital Weill Cornell Medical College Houston, Texas. DVT in a Breast Cancer Patient.

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Drug Induced Hepatitis

Drug Induced Hepatitis. Clinical Presentation. 68 year old woman Jaundice Mild epigastric pain Fatigue Pruritus Dark urine/light stools Diarrhea X 4 1/2 months 6 months prior. 7 days. Diarrhea. LFTs  nl stools  C&S, O&P, Giardia. 2 months.

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HEPARIN INDUCED THROMBOCYTOPENIA (HIT)

HEPARIN INDUCED THROMBOCYTOPENIA (HIT). HEPARIN-INDUCED THROMBOCYTOPENIA. Causative agents. Unfractionated heparin (UFH) (beef > pork) Continuous iv infusion Cardiopulmonary bypass Low dose sq Heparin flushes Heparin-bonded catheters Low molecular weight heparin

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Heparin Induced Thrombocytopenia

Introduction. Life-threatening disorder that follows exposure to unfractionated or (less commonly) low-molecular-weight heparin. Patients classically present with a low platelet count (<150,000 per cubic millimeter) or a relative decrease of 50 percent or more from baseline, although the fall may b

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Drug Induced Arrhythmia

Drug Induced Arrhythmia. Dr. SH TSUI 15 June 2005. ECG Disturbances in Poisoned Patients. Fast rate Slow rate Abnormal rhythm/pattern Focus: Underlying mechanism and patho-physiology. Cardiovascular Physiology . Electrolyte movement and action potential.

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Heparin-Induced Thrombocytopenia

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Drug-Induced Seizures

Drug-Induced Seizures. Dr Ian TF Cheung AED Prince of Wales Hospital. 9th March 2005. Definitions. Seizure Abnormal electrical activity of the brain Leads to loss of neurologic function Abnormal motor, sensory, cognitive, or emotional activity Leads to abnormal behaviors

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Drug-induced Kidney Disease

Drug-induced Kidney Disease. I ntroduction . The kidney maintains the vital functions of clearing excess body fluid and removing metabolic and exogenous toxins from the blood The kidney is particularly vulnerable to drugs and other agents that cause renal damage

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Heparin-induced thrombocytopenia (HIT)

PCI Vascular devices VTE prophylaxis Postop anticoag. Where Do We Use Heparin?. Heparin-induced thrombocytopenia (HIT). The Overuse of Heparin.

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HEPARIN INDUCED THROMBOCYTOPENIA

HEPARIN INDUCED THROMBOCYTOPENIA. GALILA ZAHER MBB ch, dip C Path, MRC Path. Heparin induced thrombocytopenia(HIT). HIT: is an immune mediated side effect which can be life threatening . Incidence : 1-3%of patient receiving heparin. Heparin induced thrombocytopenia.

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Heparin-Induced Thrombocytopenia

Heparin-Induced Thrombocytopenia. Heparin-- Required for inhibition of thrombin. Thrombin. Heparin ( &gt; 18 monosaccharide units). Antithrombin. Petitou and van Boeckel, Angew Chem Int Ed 2004; 43: 3118. Mechanism of Action of UFH, Fondaparinux, LMWH. Heparin and Clotting.

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Drug Induced Glaucoma

Drug Induced Glaucoma. Jorge L. Fernandez-Bahamonde, MD. Definition. Topical, peri-orbital, local or systemic medications that lead to increase IOP and subsequent glaucoma. Corticosteroids. Non-steroidals agents. Corticosteroids. Most common cause is from topical administration.

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Drug induced nephrotoxicity

Drug induced nephrotoxicity. Naser Hadavand. Classification of Drug Induced Disordres. Definitions Type Onset Severity. Definition and Classifications of Adverse Reaction Terms. Adverse Event: Adverse Drug Reaction: Side Effect:. Comparison Type A and Type B.

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Drug-Induced Bleeding

Drug-Induced Bleeding. Christian von Heymann. Outline. Pharmacology of unfractionated heparin (UFH) low molecular weight heparin (LMWH) danaparoid hirudin fondaparinux Algorithm for treatment of bleeding induced by these drugs. Unfractionated Heparin (UFH) Pharmacology.

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Drug-induced Urticaria

Drug-induced Urticaria. How often is it?. Drug-induced Urticaria. How often is it? What does it look like?. Drug-induced Urticaria. How often is it? What does it look like? What does it not look like?. Drug-induced Urticaria. How often is it? What does it look like?

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Heparin-Induced Thrombocytopenia

Heparin-Induced Thrombocytopenia. Dr Vinod. HIT. An immunoglobulin-mediated adverse drug reaction characterized by: platelet activation thrombocytopenia thrombotic complications. Incidence. Depends on clinical setting Medical or surgical Type of Heparin UFH-more

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Heparin-Induced Thrombocytopenia (HIT)

Heparin-Induced Thrombocytopenia (HIT). Treatment with danaparoid (Orgaran  ). Management of HIT – treatment. Stop all heparin (both unfractionated and low-molecular-weight heparin) Initiate alternative non-heparin anticoagulant because of high risk of symptomatic thrombosis

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Heparin-Induced Thrombocytopenia (HIT)

Heparin-Induced Thrombocytopenia (HIT). Heparin-Induced Thrombocytopenia (HIT). HIT is an immune-mediated adverse effect of heparin that paradoxically increases risk of thrombosis. HIT is a clinico-pathological syndrome. Thrombocytopenia and/or Thrombosis. Clinical. Pathological.

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Thrombocytopenia

Thrombocytopenia. ITP. Platelets. Platelets are an important component in the first phase of hemostasis - platelet plug formation When platelets are reduced in number or do not function normally, bleeding may occur. Platelets. The types of bleeding seen in platelet disorders include:

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Drug Induced Injury

Drug Induced Injury. The contribution of statistics to establishing ‘cause’. Statistics in Law. Statistics is about ‘description’, ‘estimation’ and ‘probability / likelihood’. Statistics play a part: ‘Sally Clark’ case  Probability of two cot deaths  1 in 73 million

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Heparin-Induced Thrombocytopenia

Heparin-Induced Thrombocytopenia. Lawrence Rice, MD Chief, Division of Hematology Clinical Chief, Hem/Onc Service The Methodist Hospital Weill Cornell Medical College Houston, Texas. DVT in a Breast Cancer Patient.

333 views • 22 slides