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CARBON AND MOLECULAR DIVERSITY

CARBON AND MOLECULAR DIVERSITY. The structure and function of macromolecules: Proteins and Nucleic Acids Chapter 5. Objectives. Describe the properties of a Protein

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CARBON AND MOLECULAR DIVERSITY

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  1. CARBON AND MOLECULAR DIVERSITY The structure and function of macromolecules: Proteins and Nucleic Acids Chapter 5

  2. Objectives • Describe the properties of a Protein • Understand how proteins are structured. Be able to explain each level of organization affects the shape and specificity of the protein • Describe the properties of a Nucleotide • Describe the differences in structure between major nucleic acids and how the structure correlates with function

  3. PROTEINS: MOLECULAR TOOLS OF THE CELL. • Amino acids: the monomer building block of Proteins • A Polypeptide is a structural term used to describe a polymer of amino acids • Protein is a functional term applied to one or more polypeptides that perform a task within a cell • Functions of proteins may include: • Structural, Storage, Transport, Hormonal, Receptor, Contractile, Defensive, Enzymatic

  4. STRUCTURE OF AMINO ACID. • Hydrogen atom. • Carboxyl group. • Amino group. • Variable R group.

  5. Peptide Bond: The covalent bond between two amino acids formed via condensation synthesis.

  6. Proteins are Flexible • Leads to complex three dimensional shapes

  7. So what. Why should we care? • Flexibility within the polypeptide chain allows for potential interactions between various regions of the polypeptide and/or with other polypeptides. • This leads to diverse chemical structures, each potentially capable of performing a different role within the cell.

  8. FUNCTION DEPENDS ON SPECIFIC CONFORMATION. • Primary level of organization • Sequence of amino acids, numbered from the amino end • Secondary level of organization • H bond interactions between the amino acid • Tertiary level of organization • “R” group interactions • Quaternary level of organization • subunit interactions

  9. Protein Structure • Primary level of organization • Defined as the sequence of amino acids • Numbered from the amino end • Each protein has a unique combination of amino acids

  10. Protein Structure • Secondary level of organization • H bond interactions between the amino and carbonyl groups of amino acids •  helix, H bonds between every 4th AA • Pleated sheet, H bonds between protein regions lying parallel to each other

  11. Pleated sheet: H bonds between protein regions lying parallel to each other; drawn as arrows in models •  helix: H bonds between every 4th AA

  12. Protein Structure • Tertiary level of organization • “R” group interactions, bonds • Disulfide bridges • Ionic bonds • H bonds • Hydrophobic interaction between nonpolar AA • reinforced by van der Waals

  13. Protein Structure • Quaternary level of organization • subunit interactions

  14. Changes in Protein Conformation • Denaturation: loss of a protein’s shape • Principally influenced by • pH: Disrupts H-bond interactions • Temperature: May break disulfide bonds • Protein folding is sometimes assisted by molecular chaperone proteins

  15. NUCLEIC ACIDS: INFORMATIONAL POLYMER • Nucleic acids are polymers of monomer units called nucleotides • Nucleic acids store and transmit hereditary information: gene • Two major forms of nucleic acid polymers: DNA and RNA

  16. Nucleotide Structure • Three parts to the monomer • Phosphate group • Sugar • Ribose • Deoxyribose • Nitrogenous base: • Pyrimidine • Purine

  17. Nucleic Acids Polymers • Nucleotide polymers are created via phosphodiester linkages between the phosphate of one nucleic acid and the sugar of another

  18. Synthesis is 5’-3’ • Because of the action of the enzymes involved in the attachment of the monomer units, nucleic acid synthesis always occurs from 5’ toward 3’ end

  19. Monomer Unit Created During Synthesis • The nucleotide monomer is created during polymerization from a higher energy molecule: the nucleoside.

  20. Nucleic Acids • DNA: Pyrimidines on one chain are attracted to Purines on an adjacent chain, H bonds

  21. RNA Structure • RNA is also synthesized from nucleosides where Ribose is the sugar and the nitrogenous base Uracil replaces that of Thymine • Unlike DNA, RNA functions as a single polymer but may “double up” on itself via complimentary base pairing

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