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PolExGene

PolExGene. 18 Months Midterm Meeting Ghent, 17-18 / 12 / 2007. WELCOME IN GHENT. Sixth Framework Programme Priority 1 Life Sciences, Genomics and Biotechnology for Health. PolExGene

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PolExGene

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  1. PolExGene 18 Months Midterm Meeting Ghent, 17-18 / 12 / 2007 WELCOME IN GHENT

  2. Sixth Framework Programme Priority 1 Life Sciences, Genomics and Biotechnology for Health PolExGene Biocompatible non-viral gene delivery systems for the ex vivo treatment of ocular and cardiovascular diseases with high unmet medical need Contract number: LSHB-CT-019114 Coordinator: Prof. Dr. E. Schacht (UGent) Scientific/Technical Supervison: Prof. P. Dubruel 18 Months Midterm Meeting Ghent, 17-18 / 12 / 2007

  3. PARTICIPANTS UGent:E. Schacht, P. Dubruel, V. Vermeersch, S. Van Vlierberghe UH.FP:A. Urtti, A. Subrizi IBMT:H. Thielecke, H. Bueth IMIC:B. Rihova, M. Sirova ENS:A. Joliot, L. Tibaldi UAT:T. Peters, S. Julien ARK:Jani Raty (not present due to serious health problems) UKU:T. Wirth CNRS:J. Martinez, G. Subra, M. Amblard EU: J. Sautter (EC-coordinator)

  4. Reports per partner Results obtained during past months Planning for next term Planning for next 6 months Deviations from original planning

  5. AGENDA 18 MONTHS MEETING Monday morning 08.30 Welcome (E. Schacht) Items to be discussed : - results past 6 months - adjusted table of deliverables - planning for next term- adjusted milestones - deviations from planning - financial report firstterm - actions for mid-term report 08.50 Presentation UGent 09.20 Presentation UH.FP 09.50 Presentation IBMT 10.20 Coffee break 10.50 Presentation IMIC 11.20 Presentation ENS 11.50 Presentation UAT 12.30 Lunch

  6. Monday afternoon 14.30 Presentation ARK (representative not present) 15.00 Presentation UKU 15.30 Presentation CNRS 16.00 Coffee break 16.30 Summary of the situation and review of the project technical objectives and timescale : deliverables, milestones Deviations from original planning and corrective actions 17.30 Discussion of draft mid term periodic report (scientific and financial) 18.30 End of the meeting and conclusions for 1st day (E. Schacht) 20.00 Diner at Restaurant Brasserie HA: Kouter 29

  7. Tuesday morning (1) 08.30 Welcome (E. Schacht) 08.35 Brief overview of project objectives, work packages, deliverables, time chart (E. Schacht) 08.45 Presentation of WP1 progress and planning 08.45: IBMT 08.55: ENS 09.05 Presentation of WP2 progress and planning 09.05: UGent 09.15: CNRS 09.25 Presentation of WP3 progress and planning 09.25: UGent 09.35: CNRS 09.45 Coffee break

  8. Tuesday morning (2) 10.05 Presentation of WP4 progress and planning 10.05: UGent 10.15: UH.FP 10.25: IBMT 10.35: UKU 10.45 Presentation of WP5 progress and planning 10.45: UH.FP 10.55: IBMT 11.05: ENS 11.15: UKU 11.25 Presentation of WP6 progress and planning 11.25: IMIC 11.35: UAT 11.45 Presentation of WP7 progress and planning 11.45: UAT 12.00 Lunch

  9. Tuesday afternoon 13.30 Presentation of WP8 : management structure, progress and planning 13.30: UGent (E Schacht) 13.40 :Summary of the situation and review of the project technical objectives and time scale (E. Schacht and P. Dubruel) 14.40 Summary of the project status and project meeting Recommendations for the Mid-term Report by the Project Officer Dr. J. Sautter 15.20 Closing remarks and fixing dates and venues for next meetings (E. Schacht) 15.30 End of the meeting

  10. CONCLUSIONS FROM PRESENTATIONS • Action points : Standard Protocol for transfection • Need for more efficiently transfecting polyplexes • Need for biodegradable membranes or can we reach the goal using porous PI? • Actualisation of deliverables • Actualusation of milestones • Correction actions • Actions needed to complete Mid-Term Report

  11. DELIVERABLES WP 1: D10: Cell penetrating peptides (CPP) for polyplex formulations (month 18) D11: Cell interactive peptides (CIP) for polymer membranes (month 18) WP 2: D2: Cationic polymer and cationic CPP-containing polymers as DNA binding vectors (month 12) WP 3: D5: Solvent casted and Electrospun polymer membranes based on selected biopolymers and CIP-containing biopolymers (month 15)

  12. DELIVERABLES WP 4: D1: Cell specific and therapeutic plasmids (months 9) D3: Polyplexes and CPP-containing polyplexes (month 12) D6: Polyplex containing polymer membranes (month 16) WP 5: D4: Transfected retinal/vascular cells using polyplexes (month 12) D8: Transfected retinal/vascular cells seeded on polymer membranes (month 18) D12: Polyplex containing polymer membranes seeded with retinal/vascular cells using marker genes (month 24) D14: Polyplex containing polymer membranes seeded with retinal/vascular cells using therapeutic genes (month 30)

  13. DELIVERABLES WP 6: D9: In vitro and in vivo immunologically evaluated CPP-containing polyplexes (month 18) D13: In vitro and in vivo immunologically evaluated CIP-containing polymer membranes (month 24) WP 7: D15: Retinal cell seeded polymer membranes as implants for ocular diseases (month 36) D16: Vascular cell seeded polymer membranes as coating for vascular prosthesis (month 36) WP 8: D7: 18 month report D17: 36 month report

  14. DELIVERABLES

  15. DELIVERABLES

  16. DELIVERABLES

  17. Proposal for adjusted description of deliverables

  18. MEETING AND REPORTING SCHEDULE Planned meetings: Management Board, Innovation Board and Scientific/Technical Supervision group meet every 6 months Reporting schedule: Internal report: every 6 months EU report: after 18 and 36 months

  19. WORK PACKAGES Gantt diagram

  20. PERSON MONTHS PolExGene midterm meeting Ghent, 17-18 / 12 / 2007

  21. 1. Hotel NOVOTEL 2. Hotel IBIS (Cathedral) 3. Het Pand 4. Car Parking P7 (St. Michiels) 5. Brasserie HAKouter 29, T: 09.265.91.81 1 4 3 2 Informal Dinner Monday December 17 at 20.00 HA

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