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Converting Bone Marrow Stem Cells into Liver Cells

Explore the process of converting purified bone marrow stem cells into liver cells and their potential for development in live animals through transplantation. See how stem cells differentiate into liver-like cells in a dish and a live animal setting.

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Converting Bone Marrow Stem Cells into Liver Cells

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  1. Converting Bone Marrow Stem Cells into Liver Cells

  2. Purified bone marrow stem cells from a male mouse are grown near injured liver from a female mouse, but separated by a fine filter.

  3. After 8 hours, some cells are making liver proteins, marked with green. And after 48 hours, more are differentiating into liver cells. Greenandredshow liver-specific proteins.

  4. So bone marrow stem cells can develop into liver like cells in a dish—what about in a live animal?100,000 purified bone marrow stem cells from a male mouse are transplanted into a female mouse with a injured liver.

  5. Several weeks later, the liver from the female recipient mouse is examined for the presence of male liver cells—cells containing a X and Y chromosomes. X chromosomes are pink and Y chromosomes are green. The two arrows point to male cells in this female mouse liver.

  6. For more details, please see:Hematopoietic stem cells convert into liver cells within days without fusion.Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ.Nat Cell Biol. 2004 Jun;6(6):532-9.

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