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Converting Bone Marrow Stem Cells into Liver Cells

Converting Bone Marrow Stem Cells into Liver Cells. Purified bone marrow stem cells from a male mouse are grown near injured liver from a female mouse, but separated by a fine filter.

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Converting Bone Marrow Stem Cells into Liver Cells

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  1. Converting Bone Marrow Stem Cells into Liver Cells

  2. Purified bone marrow stem cells from a male mouse are grown near injured liver from a female mouse, but separated by a fine filter.

  3. After 8 hours, some cells are making liver proteins, marked with green. And after 48 hours, more are differentiating into liver cells. Greenandredshow liver-specific proteins.

  4. So bone marrow stem cells can develop into liver like cells in a dish—what about in a live animal?100,000 purified bone marrow stem cells from a male mouse are transplanted into a female mouse with a injured liver.

  5. Several weeks later, the liver from the female recipient mouse is examined for the presence of male liver cells—cells containing a X and Y chromosomes. X chromosomes are pink and Y chromosomes are green. The two arrows point to male cells in this female mouse liver.

  6. For more details, please see:Hematopoietic stem cells convert into liver cells within days without fusion.Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ.Nat Cell Biol. 2004 Jun;6(6):532-9.

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