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Neuropathology Review Questions. 11/30/12. Match the tumor with the description. Antoni A areas Antoni B areas Verocay bodies Axons present between tumor cells Plexiform type strongly associated with NF1. Neurofibroma Schwannoma Both Neither. Schwannoma. Schwannoma. Schwannoma.
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Neuropathology Review Questions 11/30/12
Match the tumor with the description Antoni A areas Antoni B areas Verocay bodies Axons present between tumor cells Plexiform type strongly associated with NF1 • Neurofibroma • Schwannoma • Both • Neither Schwannoma Schwannoma Schwannoma Neurofibroma Neurofibroma
Schwannoma • Neoplasticschwann cells in two basic patterns • Antoni A • Compact • Spindle cells • Collagen abundant • Antoni B • Loose • Stellate round cells • Microcysts
Schwannoma • Verocay bodies • In Antoni A areas • Anuclear areas with palisading cells
Schwannoma • Benign • No sex predominance • Mean age 40-50 years • Occasionally multiple • With NF2 or schwannomatosis • Neural crest origin • Frequently affect sensory nerves • May be cystic, hemorrhagic • S100 positive
Schwannoma • Intracranial • Superior vestibular nerve • Internal acoustic meatus at root entry zone • Trigeminal nerve • Middle fossa, posterior fossa or both • Spinal • Intraspinal or dumbell shaped • Head & Neck • Posterior mediastinum • Retroperitoneum • Flexor surfaces of extremities
Neurofibroma • Peripheral nerve sheath tumor • Mix of Schwann cells, perineuralcells, fibroblasts • Hypocellular with mucoid matrix • Collagen bundles follow nerve fibers • Entrapped axons, ganglion cells • Tactilelike structures • Resemble Meissnerian corpuscles
Neurofibroma • Any age • No sex predominance • Not intracranial • Solitary cutaneous nodules • From small terminal nerves • Potential for malignant transformation
Neurofibroma Types • Cutaneous • Painless, unencapsulated • Solitary, low malignant potential • Multiple = NF1 • Intraneural • Large nerve trunks • NF1 (plexiform = pathognomonic for NF1) • “bag of worms” • Malignant potential
Match the time period after an infarct with the histologic appearance Lipid laden macrophages first appear Fibrillaryastrocytes at periphery Gemistocyticastrocytes at periphery Polymorphonuclear infiltrate Neuronal necrosis first apparent • 12-24h • 1-2d • 5-7d • 10-20d • >3mo 5-7d >3mo 10-20d 1-2d 12-24h
Infarction • 12-24 hours • Ischemic neuronal necrosis • Possibly as little as one hour • Softening & discoloration • Circumscribed pallor
Infarction • 1-2 days: PMN infiltration • 2-5 days: Astrocyte retraction balls, BBB breakdown, edema • 5 days: Macrophages (gitter cells), neovascularization • 2 weeks: Gemistocyticastrocytes • 3 months: Fibrillaryastrocytes, preservation of outer cortical layer