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Altermune

Altermune. Kary B. Mullis. The α -gal epitope. α -gal is NOT produced in humans, chimps, orangutan or gt -/- mouse A strong anti- α -gal response is already ubiquitous in all humans. The anti-Gal response. 0.1uM IgG 2. Altermune Linker. Aptamer will bind to M2e. alpha-gal epitope.

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Altermune

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  1. Altermune • Kary B. Mullis

  2. The α-gal epitope • α-gal is NOT produced in humans, chimps, orangutan or gt -/- mouse • A strong anti-α-gal response is already ubiquitous in all humans

  3. The anti-Gal response 0.1uM IgG2

  4. Altermune Linker Aptamer will bind to M2e alpha-gal epitope

  5. The Altermune Linker

  6. Spiegelmer Strategy • Eulberg and Klussmann ChemBioChem 2003

  7. Altermune linker attaches to pathogen

  8. Altermune linker attracts alpha-Gal antibodies

  9. M2target of amantadine

  10. M2e MSLLTEVET: The Achilles Heel of influenzais bicistronic

  11. A human to human influenza virion detected by Altermune

  12. natural killer cell attacks infected cell

  13. Total DNA Linker

  14. Today Model system with Ab to Phenylarsonate and Haemophilus influenza bacteria in rats. gt-/- mice Building linker to hemagglutinin peptide from H3N2 Made M2e peptides

  15. Aptamer binds to 161 aa peptide from H3N2 hemagglutinin Ruth Arnon, JBC 279, 2004

  16. Appendix A Reduction of infectivity in vitro of influenza virus on chicken cells by Altermune linker (apt-gal).

  17. Appendix B

  18. The Future: • Priming the immune system • for specific diversion by Altermune

  19. A set of immunogens is chosen for: • Convenient synthesis • Safety • The distinct spectrum of immune responses provoked

  20. Various immunogens with their resultant immune responses

  21. M13 Filamentous Phage

  22. Dr. Alex Lucas, Childrens’ Hospital of Oakland Research Institute, Oakland, CA Dr. Rick Lyons, University of New Mexico, Albuquerque Dr. Ron Cook, Biosearch, Novato, CA Dr. Carol Cardona, UC Davis, CA Dr. Jeeva Vivikananda, Dr. Jonathan Kiel, Brooks Air Force Base, San Antonio, TX Collaborators

  23. supported by DARPA

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