1 / 10

Introduction

Introduction. Rhonda El-Sheikh Department of Psychiatry and Behavioral Neuroscience Brain Research And Imaging Neuroscience Background MS in Biomedical Engineering, Neurophysiology minor, May 2004 Wayne State University BS in Computer Science, Telecommunications minor, December 2000

azriel
Download Presentation

Introduction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Introduction • Rhonda El-Sheikh • Department of Psychiatry and Behavioral Neuroscience • Brain Research And Imaging Neuroscience • Background • MS in Biomedical Engineering, Neurophysiology minor, May 2004 • Wayne State University • BS in Computer Science, Telecommunications minor, December 2000 • Michigan State University

  2. Introduction • Main Focus • Magnetic Resonance Spectroscopy (MRS) • Quantifying both 31P, and 1H MRS data • Morphometrics • Collecting volumetric data based on a region-of-interest (ROI) approach • Using a Talairach-Brodmann atlas to refine ROI definitions of Brodmann areas in vivo

  3. Differential Effects of Antipsychotic Drugs on Pituitary Volume Rhonda M. El-Sheikh1, Frank P. MacMaster1, Ameet R. Upadhyaya1, Jeffrey Nutche2, David R. Rosenberg1, Matcheri S. Keshavan1; 1Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 2Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 1st June, 2005

  4. Objective • To examine the effect of antipsychotics on pituitary volume • Antipsychotics are known to affect pituitary function leading to robust prolactin elevations • Increased prolactin may be associated with structural alterations in pituitary volume

  5. Methods • Using structural magnetic resonance imaging (MRI) scans, pituitary volumes were measured in a series of five samples • A. Before and after treatment samples • PSY: Treatment naïve first episode psychotic patients (primarily taking risperidone or olanzapine) • OCD: Obsessive compulsive disorder patients • MDD: Major depressive disorder patients • ADHD: Attention deficit hyperactivity disorder patients • B. Unmedicated healthy controls

  6. Sample Information and Change in Pituitary Volume *Significant at p < 0.05

  7. Results • Pituitary volume significantly increased in the PSY subjects after successful treatment, as opposed to healthy controls • t[17] = 2.44, p = 0.026, 11% increase; 1% increase respectively • Risperidone produced larger increases in pituitary volume as opposed to olanzapine • 13% increase; 3% increase respectively • There was no effect of treatment noted in the OCD, MDD and ADHD groups, despite symptomatic improvement

  8. Conclusions • Pituitary volume increases appear specific to antipsychotic treatments, especially prolactin elevating drugs (i.e. risperidone) in contrast to prolactin sparing drugs (i.e. olanzapine) • Pituitary volumes may be a biomarker for treatment related neuroendocrine dysfunctions • Future studies should combine neuroendocrine measures with pituitary volumetric measures

More Related