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*. *. *. *. *. A. *. Relative apoptosis. Relative proliferation. 1. 2. miR-138 mimic control mimic anti-miR-138 LNA control LNA FOSL1 siRNA control siRNA. -. -. -. -. -. -. -. -. -. -. -. -. -. -. -. -. +. +. +. +. 1. 0.5. -. -. -. -. -. -. -. -.

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  1. * * * * * A * Relative apoptosis Relative proliferation 1 2 miR-138 mimic control mimic anti-miR-138 LNA control LNA FOSL1 siRNA control siRNA - - - - - - - - - - - - - - - - + + + + 1 0.5 - - - - - - - - - - - - 1 - - - - - - - - 1 + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + 0.5 0 0.5 0 - - - - - - - - - - - - - - - - - - - - + + + + - - - - - - - - - - - - - - - - - - - - + + + + 0 - - - - 0 * * * C UM1 UM1 UM1 UM1 686Tu 686Tu 686Tu 686Tu * * * Relative cell migration Relative cell invasion miR-138 mimic control mimic anti-miR-138 LNA control LNA FOSL1 siRNA control siRNA B D Supplementary Figure 5: The effect of miR-138 and FOSL1 on HNSCC cells. UM1 cells were treated with either miR-138 mimic or control mimic, or FOSL1 specific siRNA or control siRNA, and 686Tu cells were treated with either anti-miR-138 LNA or negative control LNA. The proliferation (A), apoptosis (B), cell migration (C), and invasion (D) were performed on these cells as described previously [12,31]. Data represents at least 3 independent experiments with similar results. * indicates p < 0.05.

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