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PREVENTION OF GROUP B STREPTOCOCCUS INFECTION IN THE NEONATE

2. EPIDEMIOLOGY. KNOWN CAUSE OF BOVINE MASTITISCONSIDERED AS SIGNIFICANT PATHOGEN SINCE 1970'SINCIDENCEEARLY ONSET 1.1-3.7/1000 LIVE BIRTHSLATE ONSET 0.6-1.7/1000 LIVE BIRTHSCASE FATALITY RATIO 11-14%. 3. IMPACT OF GBS INFECTION. ESTIMATED 11,000 CASES/YEAR IN US2500 INFANT DEATHS/YEAR1350

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PREVENTION OF GROUP B STREPTOCOCCUS INFECTION IN THE NEONATE

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    1. 1 PREVENTION OF GROUP B STREPTOCOCCUS INFECTION IN THE NEONATE Rene L. Santin M. D. Texas Tech University Health Sciences Center Pediatric Infectious Diseases Rotation

    2. 2 EPIDEMIOLOGY KNOWN CAUSE OF BOVINE MASTITIS CONSIDERED AS SIGNIFICANT PATHOGEN SINCE 1970’S INCIDENCE EARLY ONSET 1.1-3.7/1000 LIVE BIRTHS LATE ONSET 0.6-1.7/1000 LIVE BIRTHS CASE FATALITY RATIO 11-14%

    3. 3 IMPACT OF GBS INFECTION ESTIMATED 11,000 CASES/YEAR IN US 2500 INFANT DEATHS/YEAR 1350 CHILDREN WITH PERMANENT NEUROLOGIC SEQUELAE PERMANENT NEUROLOGIC SEQUELAE IN MENINGITIS SURVIVORS: 25 - 50 %

    4. 4 GROUP B STREPTOCOCCUS Streptococcus agalactiae GRAM + DIPLOCOCCUS Beta-HEMOLYTIC, ENCAPSULATED 8 SEROTYPES Ia, Ib, Ic, II, III, IV, V, VI

    5. 5 GBS COLONIZATION IN MOTHER LOWER GENITAL TRACT ANORECTUM URINARY TRACT IN NEONATES EXTERNAL EAR (IN FIRST 24 H ) ANTERIOR NARES, THROAT ANORECTUM UMBILICUS

    6. 6 TYPES OF GBS INFECTIONS EARLY ONSET LATE ONSET SYSTEMIC CNS BACTEREMIA W/O FOCUS SEPTIC ARTHRITIS, OSTEOMYELITIS CELLULITIS, ADENITIS OTHER SITES (UNUSUAL)

    7. 7 EARLY ONSET GBS INFECTIONS ONSET < 7 DAYS 60-80 % PRESENT AT FIRST 24 H MEDIAN AGE AT ONSET TERM 8 HOURS PRETERM 6 HOURS

    8. 8 RISK FACTORS FOR GBS INFECTION PREMATURE ONSET OF LABOR PROLONGED RUPTURE OF MEMBRANES > 18 H BEFORE DELIVERY MATERNAL CHORIOAMNIONITIS EARLY POST PARTUM FEBRILE MORBIDITY MULTIPLE BIRTHS

    9. 9 CLINICAL MANIFESTATIONS OF EARLY ONSET GBS INFECTION

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