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Simulation of a Cochlear Model as a Descriptive Tool for Normal and Abnormal Auditory Functioning

Simulation of a Cochlear Model as a Descriptive Tool for Normal and Abnormal Auditory Functioning. Miriam Furst-Yust Azaria Cohen, Vered Weisz, Noam Elbaum, Yaniv Halmut, Dan Mecrantz, Oren Bahat, and Udi shtalrid Dept. of Electrical Engineering-Systems Tel Aviv University.

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Simulation of a Cochlear Model as a Descriptive Tool for Normal and Abnormal Auditory Functioning

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  1. Simulation of a Cochlear Model as a Descriptive Tool for Normal and Abnormal Auditory Functioning Miriam Furst-Yust Azaria Cohen, Vered Weisz, Noam Elbaum, Yaniv Halmut, Dan Mecrantz, Oren Bahat, and Udi shtalrid Dept. of Electrical Engineering-Systems Tel Aviv University

  2. Clinical Audiometric Tests • Audiograms • Speech Discrimination Tests • Otoacoustic Emissions

  3. Audiometric Diagnosis • Conductive or Sensorineural Hearing Loss • Cochlear or Retrocochlear Hearing Loss • Inner Hair Cells or Outer Hair Cells Loss ? • The amount of Outer hair Cell Loss?

  4. Can a Cochlear model help in Audiometric Diagnosis ?

  5. The Ear

  6. Tonotopic map of the Cochlea Traveling Waves

  7. Basilar Membrane Motion +Outer Hair Cells Amplification Outer Hair Cell

  8. Cochlear Model • One dimensional model • Based on fluid dynamics

  9. Outer Hair Cell Model • Electromotile model • OHC adds to basilar membrane pressure

  10. Outer ear Middle ear TM Incudostapedial joint microphone Middle Ear Model • Piston based model Oval window

  11. Cochlear Representationsof Tones Cochlear representation

  12. Input Signal : Chirp 1-3 KHz INPUT OUTPUT Normal Cochlea OHC Loss Cochlear Representation of Chirp

  13. 100us Cochlear Representation of a click Healthy Cochlea OHC Loss Stapes Apex Stimulus

  14. Representation of a word Input Signal: The word “SHEN” INPUT OUTPUT Normal Cochlea OHC Loss

  15. Cochlear Representation of a Noisy Word Input Signal: The word “SHEN” with Noise INPUT OUTPUT Normal Cochlea OHC Loss

  16. Otoacoustic Emission

  17. Introducing cochlear “roughness”

  18. Model Prediction: Excitation Patterns Normal Cochlea Damaged Cochlea No Active Outer Hair Cells

  19. Estimated Audiograms Normal OHC activity Partial damaged OHC No OHC activity

  20. Estimated Audiograms

  21. Simulated Audiograms Normal OHC activity with “roughness” Partial OHC activity with “roughness”

  22. Damaged cochlear response

  23. Partial OHC Loss • Measured Audiogram Model Prediction

  24. Non Linear Properties

  25. Equal Loudness Countours

  26. Non Linear Respomse • טון בודד – פילטרים D=2.3cm CF=488Hz D=1.8cm CF=1074Hz

  27. Basilar Membrane Gain

  28. Response to Two Tones:Combination Tones Healthy Cochlea Time Frequency Input = 2kHz + 2.44kHz; Equal level

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