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Welcome to Immunology Course

Welcome to Immunology Course. IMMUNOLOGY. Prof. dr Vera Pravica Prof. dr Dušan Popadić Doc. dr Miloš Marković Assist. dr Emina Savić imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic. Basic terminology. Immunitas (lat.). p rotection , immunity. Immunis,-e (lat.).

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Welcome to Immunology Course

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  1. Welcome to Immunology Course

  2. IMMUNOLOGY Prof. dr Vera Pravica Prof. dr Dušan Popadić Doc. dr Miloš Marković Assist. dr Emina Savić imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic

  3. Basic terminology Immunitas (lat.) protection, immunity Immunis,-e (lat.) protected, immune Protection of senators against prosecution, tax payment and other civil dutiesin Antic Rome Immunity state of resistance to (infectious)disease processthat results in immunity Immunization resistant to (infectious) disease Immune Immune system organs, tissues, cellsandmolecules involved in defence of the organism coordinated activity of the immune system components Immune response

  4. Basic function(s) of the immune system Defense against infectious agents Recognition and elimination of cancer cells

  5. viruses fungi protozoa bacteria helmints

  6. IMMUNOLOGYinvestigates - mechanisms of recognition of “danger” signal - mechanisms of activation and regulation of defense • effectormechanisms of destruction and elimination of • pathogens and neutralization of their harmful products - mechanisms leading to immune response injurious to own tissue - possibilities for manipulation of the immune response

  7. ADAPTIVE (Aquired) INNATE (Natural) (Native) IMMUNITY

  8. Mechanisms of innate and adaptive immunity INNATE IMMUNITY ADAPTIVE IMMUNITY - appears in vertebrates - filogenetically older - immediate action • fully functional after certain period • (days, weeks) - amplified upon re-exposure to the same pathogen - does not change throughout a lifetime - reacts predominantly against infectious agents • reacts against both infectious and • non-infectious substances - early line of defence • later but more effective Mutually stimulating

  9. Principle mechanisms of innate and adaptive immunity

  10. Properties of adaptive immunity - diversity and specificity - memory - clonal expansion - specialization - autotolerance - stimulation of mechanisms of innate immunity

  11. Types of adaptive immunity - based on effector mechanisms cellular or cell-mediated (T-lymphocytes) humoral (B-lymphocytes)

  12. Types of adaptive immunity

  13. Types of adaptive immunity - based on effector mechanisms cellular or cell-mediated (T-lymphocytes) humoral (B-lymphocytes) • - based onmanner of activation • active • passive • - based onmode of induction • natural • artificial

  14. NATURAL (infection) ACTIVE ARTIFICIAL (vaccination) IMMUNIZATION NATURAL (Mother-to-fetus antibody transfer) PASSIVE ARTIFICIAL (serum therapy)

  15. Simplified presentation of immune network

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