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Emerging Medical Technologies: Next Gen Sequencing

Delve into the world of Next-Generation Sequencing (NGS) to uncover its applications in medicine, from infectious diseases to cancer and prenatal care. Learn about the evolution from Sanger to NGS and the revolutionary Portable Sequencer (MinION) that fits in your palm for efficient DNA analysis.

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Emerging Medical Technologies: Next Gen Sequencing

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  1. Emerging Medical Technologies: Next Gen Sequencing Cynthia N Perry, PhD Assistant Academic Dean of Admissions Assistant Professor, Molecular Medicine Department of Medical Education Foster School of Medicine

  2. Genomics and Healthcare https://youtu.be/KiQgrK3tge8

  3. Human Genome • 3 billion bases arrayed in a unique order, • with ~20,000 genes that direct the synthesis of all the proteins • ~1/1,000,000th of the Human Genome • Polymorphisms or SNPs which differ between people • May influence traits • Possible medical importance

  4. History of DNA Sequencing • 1st Generation = Sanger Sequencing • 2 reads (forward & reverse) • 2nd Generation = Next Generation Sequencing • Millions of reads • 3rd Generation = Single Molecule Sequencing

  5. Sanger Sequencing

  6. Sanger Sequencing

  7. From Sanger to Next-Gen Sequencing

  8. Next Generation Sequencing

  9. Applications IN MEDICINE

  10. Applications in Medicine-Infectious diesease • Clinical Test for TB Patient • Take a sputum sample • Begin culture • ID drug susceptibility ID by NGS

  11. Applications in Medicine - Cancer

  12. Applications in Medicine - prenatal care

  13. Broad Applications • Paternity testing • Wildlife conservation • Herbal supplement validation • Ancestral migration patterns • Origins of traditional medicine

  14. Portable Sequencer (MinION) • Pocket-sized, portable device for biological analysis • Up to 512 nanoporechannels • Simple 10-min sample prep available • Real-time analysis for rapid, efficient workflows • Adaptable to direct DNA or RNA sequencing

  15. Portable Sequencer (MinION)

  16. Next Generation Sequencing In the palm of your hand Practical module Miki Wang, Cynthia Perry, and Jorge Cervantes

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