Unlocking Brain Health: Comprehensive Neurotherapy Centers

1. The Brain Gym A Neurotherapy Center

2. Problem… Medical Science will not have a solution for Parkinson’s ready within a timeframe relevant to the majority already diagnosed. Why?....

3. We Don’t Know What The Disease Is… “The brain is so complicated, I seriously doubt that it comes down to one protein. If it really was that simple, then we would probably be too simple to understand it.” – Dr. Simon Stott

4. We Don’t Understand Biology “Generally I think we understand less than 1/10,000 of all that there is to understand in biology. We know virtually nothing about how biology is controlled and how it works….There isn’t a lot of funding to do the fundamental research on one gene or one protein that would be needed to really understand these things…funding bodies want us to solve diseases and work with companies to figure out shortcuts that can be made into a drug. But we don’t have the fundamental basis that is needed to really solve these problems.” - Prof. Dario Alessi

5. Science Is Skewed “As researchers, we are lucky that society has blind trust in us, there is no accountability, apart from showing our publications. All scientists have good intentions and have committed to this profession for the right reasons, but we get trapped into this wheel that creates science for scientists rather than science for society.”  – Prof. HilalLashuel

6. No One Collaborates “There are people studying just (mitochondrial) bioenergetics or protein import or calcium, that don’t really know much about the other aspects of mitochondria. That is a big challenge, we spend decades becoming specialists, but now we need to back up and work together so we can put the whole puzzle together.” – Prof. Heidi McBride

7. Drug Development Takes Forever 12-18 Years From Start to Finish!

8. We Can Only Go After One Target At a Time “Once you’ve got two or more variables it becomes incredibly hard to work out what is important. Everything we do is dependent upon solving one variable at a time, which is very inefficient. No one has come up with a better way yet.” - Prof. John Hardy

9. We Have Been Looking Under the Wrong Lamp Post “…we mostly focus on the risk factors that lead to the disease. We haven’t really started to look seriously at those factors that lead to faster or slower decline, which is what patients care most about.” – Prof. BeateRitz

10. We Treat Everyone As If They Had the Same Disease… Courtesy of Prof. Alberto Espay

11. Clinical Trials Suck • “….clinical trials are a terrible way to test a scientific hypothesis. There are so many reasons why a clinical trial can fail that have nothing to do with the basic science behind the trial. The dose could be wrong, the drug might not be hitting the target effectively, etc. Unfortunately when a trial fails it could lead to the death of that target because investors will be more hesitant to put money into similar drugs for the same target.” – Prof. Timothy Greenamyre

12. No Wonder We Have Had Nothing But Failure So Far

13. Meanwhile The Problem is Growing Quickly E. Ray Dorsey, Todd Sherer, Michael S. Okun and Bastiaan R. Bloem. The Emerging Evidence of the Parkinson Pandemic. Journal of Parkinson’s Disease 8 (2018) S3–S8 DOI 10.3233/JPD-18147

14. And Patients Are Left To Deal With All Of This On Their Own

15. Leaving An Inconvenient Truth The pace of therapeutic development is bogged down by a system that cannot keep up with our degeneration.

16. Solution Comprehensive Neurotherapy Centers designed to optimize everything we know about brain health.

17. The Bet A network of neurotherapy centers will help more people than any disease modifying therapy in development

18. What’s Out There… Laurie Mischley’s Summer School (bastyrpdschool.org) • Once a year camp, 80+ participants annually, focus on nutrition and education but also has an exercise and wellness component. • Major limitation is that it is only offered once a year Other Retreats: Rise PD Retreat, PWR! Retreat, Kripalu, - Each Limited in scope and just a week at most. • European Parkinson Therapy Centre • Offers one and two week recovery programs, works with local academic centers • But remote location in Northern Italy

19. We can do better…

20. Comprehensive Neurotherapy Centers designed to optimize all aspects of brain health.

21. Core Pillars…

22. Exercise Customized plan with a wide range of activities and sports to choose from + 1 on 1 time with a physiotherapist Classes offered – Boxing, Kickboxing, Swimming, Yoga, Pilates, Hiking, Dance, Ping Pong, Skills training etc. etc. But Safety First Kids! Cus you can’t move if you break something.

23. Nutrition Upon arrival all of your vitamin and nutrient levels will be checked. Using this information a team of nutritionists will create a diet plan tailored to your specific needs.

24. Sleep • “the shorter your sleep, the shorter your life. The leading causes of disease and death in developed nations—diseases that are crippling health-care systems, such as heart disease, obesity, dementia, diabetes, and cancer—all have recognized causal links to a lack of sleep.” ― Matthew Walker, Why We Sleep • Track your sleep with passive sleep monitoring devices to let you know how well you sleep • Learn everything you need to know about how to sleep properly • Working with a sleep specialist to ensure you sleep as well as possible

25. Other Therapists on staff to help you deal with any stress or anxiety you might be experiencing + meditation and yoga classes We will also offer a variety of educational classes to teach you whatever you want to know about the brain/disease.

26. Facilities • Pool • Boxing Gym • Yoga Studio • Hiking Trails • Weight Room • Games Room • Etc.

27. Staff • Physiotherapists • Speech Pathologists • Nutritionists • Clinical Researchers • Sleep Specialists • Counselors Therapists • Medical Consultants

28. Programs Customizable 1, 2 and 4 week programs Typical Daily Schedule: _____________________________ • 7-9 : Movement Class • 9-11: Breakfast + Free Time • 11-1: Learn Stuff • 1-2: Lunch • 2-3:30: Learn Stuff • 3:30-5: Movement Class • 5-8: Free time + Dinner • 8-10: Evening activity _____________________________

29. Education Programs cvx Biology The basics you need to understand the science • Physiology • Kinesiology • Physiotherapy • Etc. Managing Chronic Disease - Everything you need to know about medication, diet and exercise • Advocacy Training • Healthcare Reform • Influencing Policy Makers • Bridging researchers and patients

30. Location, Location, Location Should be: • Easily accessible to large population centers • Close to a relevant academic center and hospital • An attractive location • Easy access to all facilities • A range of hotels to accommodate all budgets

31. TimeLine Year 10 Year 20 Year 2 Year 3 Year 5 Year 1 Cure disease. Retire ;) Establish First Center Expand. Establish proof-of-concept Expand. Build program to address the needs of other diseases.

32. Our Model Treat Patients as Customers

33. The Brain Gym The world’s first truly comprehensive neurotherapy center