1 / 9

Sofosbuvir + RBV in Treatment-Naïve Genotypes 2,3 FISSION Trial*

Phase 3. Treatment Naïve. Sofosbuvir + RBV in Treatment-Naïve Genotypes 2,3 FISSION Trial*. *Note: Published in NEJM in tandem with NEUTRINO Trial (Genotypes 1,4,5,6). Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

barton
Download Presentation

Sofosbuvir + RBV in Treatment-Naïve Genotypes 2,3 FISSION Trial*

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Phase 3 TreatmentNaïve Sofosbuvir + RBV in Treatment-Naïve Genotypes 2,3FISSION Trial* *Note: Published in NEJM in tandem with NEUTRINOTrial (Genotypes 1,4,5,6) Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  2. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Features Source: Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  3. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Design Week 0 12 24 36 Sofosbuvir + RBV (weight-based) N =256 SVR12 Peginterferon + RBV (fixed-dose) N =243 SVR12 Drug DosingSofosbuvir: 400 mg once dailyPeginterferon alfa-2a: 180 µg once weeklyWeight-based Ribavirin (in 2 divided doses): 1000 mg/day if < 75kg or 1200 mg/day if ≥ 75kgFixed-dose Ribavirin (in 2 divided doses): 800 mg/day Source: Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  4. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Results FISSION: HCV RNA <25 IU/ml by Study Timepoint (GT 2, 3 Combined) 249/250 158/236 249/253 217/243 170/253 162/243 RBV = Ribavirin; PEG = Peginterferon Source: Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  5. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Results FISSION: SVR12 by Genotype 170/253 162/243 68/70 52/67 102/183 110/176 RBV = Ribavirin; PEG = Peginterferon Source: Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  6. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Results FISSION: SVR12 by Presence of Cirrhosis 147/204 143/193 23/49 19/50 RBV = Ribavirin; PEG = Peginterferon Source: Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  7. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Adverse Effects Source: Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  8. Sofosbuvir + Ribavirin for Treatment-Naïve HCV GT 2 or 3FISSION Trial: Conclusions Source:Lawitz E, et al. N Engl J Med. 2013;368:1878-87.

  9. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

More Related